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Keywords: Hippo signaling
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Journal Articles
Journal: Development
Development (2023) 150 (15): dev201483.
Published: 10 August 2023
... for Wnt and Hippo signaling during embryonic and fetal heart growth. Despite this improved understanding, no clinically relevant therapies are yet available to compensate for the loss of functional adult myocardium and the absence of mature cardiomyocyte renewal that underlies cardiomyopathies of multiple...
Journal Articles
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Neural development
Journal: Development
Development (2022) 149 (18): dev200860.
Published: 20 September 2022
...Idaliz M. Martínez Traverso; Jeffrey D. Steimle; Xiaolei Zhao; Jun Wang; James F. Martin ABSTRACT Hippo signaling, an evolutionarily conserved kinase cascade involved in organ size control, plays key roles in various tissue developmental processes, but its role in craniofacial development remains...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev182642.
Published: 2 December 2019
..., mammalian MG do not possess this ability. However, if we could understand the reasons why, we may be able to devise strategies to confer regenerative potential. The recent discovery that the Hippo signaling pathway acts as an intrinsic block to mammalian MG proliferation, along with reports of adeno...
Journal Articles
Journal: Development
Development (2019) 146 (17): dev179861.
Published: 6 September 2019
... the first 2 days of mouse embryogenesis. Preimplantation Stem cell progenitors HIPPO signaling Pluripotency describes the developmental potential to produce all adult cell types. However, in mammals, the establishment of pluripotency takes place in the context of lineage decisions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev166819.
Published: 4 April 2019
... Hippo signaling in the lymph gland. Depletion of septate-junction components in hemocytes produces similar phenotypes to those observed in Hippo pathway mutants, including increased differentiation of immune cells. Our analysis places septate-junction components as upstream regulators of the Hippo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (4): dev157545.
Published: 21 February 2018
... partner in Hippo signaling, loss of sd not only fully rescues tissue overgrowth and elevated target gene transcription induced by Yki overexpression ( Wu et al., 2008 ), it also fully rescues tissue undergrowth and decreased Hippo target gene transcription in yki loss-of-function mutations ( Koontz et...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (17): 3021–3032.
Published: 1 September 2015
... Yap/Taz and Tead are necessary and sufficient for optic vesicle progenitors to adopt retinal pigmented epithelium identity. Eye development Ocular morphogenesis Zebrafish Tfec Hippo signaling Sveinsson's chorioretinal atrophy Choroid fissure Coloboma Directed differentiation of stem...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (16): 2740–2751.
Published: 15 August 2015
... eye to investigate the mechanisms that trigger quiescent cells to re-enter the cell cycle and proliferate in response to tissue damage. We discovered that Hippo signaling regulates compensatory proliferation after extensive cell death in the developing eye. Scalloped and Yorkie, transcriptional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (11): 2002–2013.
Published: 1 June 2015
...Erika Wittkorn; Ankita Sarkar; Kristine Garcia; Madhuri Kango-Singh; Amit Singh ABSTRACT The evolutionarily conserved Hippo signaling pathway is known to regulate cell proliferation and maintain tissue homeostasis during development. We found that activation of Yorkie (Yki), the effector...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (19): 4051–4059.
Published: 1 October 2013
... are compressed. This pattern has important consequences on cell shape in the wing pouch: cells respond to it by polarizing their acto-myosin cortex, and aligning their divisions with the main axis of cell stretch, thereby polarizing tissue growth. Ectopic perturbations of tissue growth by the Hippo signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 3907–3914.
Published: 15 September 2011
...Ken-Ichi Wada; Kazuyoshi Itoga; Teruo Okano; Shigenobu Yonemura; Hiroshi Sasaki The Hippo signaling pathway plays an important role in regulation of cell proliferation. Cell density regulates the Hippo pathway in cultured cells; however, the mechanism by which cells detect density remains unclear...
Includes: Supplementary data
Journal Articles
Journal Articles