... provided that the original work is properly attributed. Highlighted Article: YAP, an intracellular mediator of the Hippo signaling pathway, establishes epiblast competency for germ cell differentiation through activation of the WNT pathway. EpiSCs PGCs Hippo pathway Pluripotent stem...

..., but can also control cell fate or tissue morphogenesis. Here, we investigate the function of the Hippo pathway during the development of cartilage, which forms the majority of the skeleton. Previously, YAP was proposed to inhibit skeletal size by repressing chondrocyte proliferation and differentiation...

... G′,J′). These results suggested core Hippo pathway components may be altered in human biliary carcinoma, particularly in extrahepatic cases. Indeed, analysis of cBioportal data is consistent with this possibility ( Fig. S7 ; Table S1 ) ( Cerami et al., 2012 ; Gao et al., 2013 ). The eventual loss...

...Samuel A. Manning; Benjamin Kroeger; Kieran F. Harvey ABSTRACT The Hippo pathway is a highly conserved signalling pathway that regulates multiple biological processes, including organ size control and cell fate. Since its discovery, genetic and biochemical studies have elucidated several key...

... signaling regulates the conversion of simple columnar epithelium into stratified squamous cells in the developing mouse and human esophagus. Esophagus YAP Progenitor cells Human pluripotent stem cells 3D organoids Hippo pathway The combination of human pluripotent stem cell (hPSC...

...: This Development at a Glance article describes the core Hippo pathway, its regulation and the roles it plays in animal development. Cell fate Differentiation Growth Hippo pathway Morphogenesis YAP The Hippo pathway was identified using Drosophila genetic mosaic screens for genes that regulate...

... ). The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila . Cell   126 , 767 - 774 . 10.1016/j.cell.2006.07.013 Udan , R. S. , Kango-Singh , M. , Nolo , R. , Tao , C. and Halder , G. ( 2003 ). Hippo promotes proliferation...

... been implicated in cardiac development but many questions remain. We have investigated the role of Wwtr1, a nuclear effector of the Hippo pathway, in zebrafish and find that its loss leads to reduced cardiac trabeculation. However, in mosaic animals, wwtr1 −/− cardiomyocytes contribute more frequently...

... , A. , Rosenfeld , R. , Le Bihan , T. and McNeill , H. ( 2009a ). The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie . Dev. Cell   16 , 411 - 420 . 10.1016/j.devcel.2009.01.010 Badouel , C. , Garg...

... 2016. Published by The Company of Biologists Ltd 2016 Summary: This Meeting Review summarises the recent RIKEN-CDB Symposium 'Size in Development: Growth, Shape and Allometry', highlighting recent advances and open questions in the field. Hippo pathway Growth control Morphogen...

...David Jukam; Kayla Viets; Caitlin Anderson; Cyrus Zhou; Peter DeFord; Jenny Yan; Jinshuai Cao; Robert J. Johnston, Jr The Hippo pathway is crucial for not only normal growth and apoptosis but also cell fate specification during development. What controls Hippo pathway activity during cell fate...

... that the original work is properly attributed. Summary: In the squamous epithelium of the mouse skin, the transcription factors YAP and TAZ are regulated by integrin-Src signalling, and are required for proliferation of skin stem/progenitor cells. Hippo pathway Integrin Yes-associated protein TAZ...

... Stroma Hippo pathway Determining how organ size is regulated, and how progenitor cells self-renew, is crucial for understanding normal development. The mammalian kidney derives from three interdependent lineages: the ureteric bud (UB), which forms the collecting ducts; the nephron progenitors...

...Xaralabos Varelas Studies over the past 20 years have defined the Hippo signaling pathway as a major regulator of tissue growth and organ size. Diverse roles for the Hippo pathway have emerged, the majority of which in vertebrates are determined by the transcriptional regulators TAZ and YAP (TAZ...

.... , Desplan C. ( 2011 ). Binary regulation of Hippo pathway by Merlin/NF2, Kibra, Lgl, and Melted specifies and maintains postmitotic neuronal fate . Dev. Cell 21 , 874 - 887 . Khan M. , Vaes E. , Mombaerts P. ( 2011 ). Regulation of the probability of mouse odorant receptor...

... of the neural tube. Loss of function of FatJ promotes an increase in dp4-vp1 progenitors and a concomitant increase in differentiated Lim1 + /Lim2 + neurons. Our studies reveal that FatJ mediates its action via the Hippo pathway mediator Yap1: loss of downstream Hippo components can rescue the defect caused...

...), stimulating their proliferation. In addition, the Hippo pathway has been recently implicated in the regulation of Upd production from the ECs. Here, we show that the Hippo pathway target, Yorkie (Yki), also plays a crucial and cell-autonomous role in ISCs. Activation of Yki in ISCs is sufficient to increase...

... lacking either gene. This study highlights the complexity employed by different SWH pathway proteins to control organ size at different stages of development. Drosophila Hippo pathway Organ size control The Salvador-Warts-Hippo (SWH) pathway is a crucial determinant of organ size...