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Keywords: Heterochronic pathway
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (5): dev164293.
Published: 7 March 2019
.... , Horvitz , H. R. and Ruvkun , G. ( 2000 ). The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor . Mol. Cell   5 , 659 - 669 . 10.1016/S1097-2765(00)80245-2 Stiernagle , T. ( 2006 ). Maintenance of C...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (5): 799–809.
Published: 1 March 2016
... regulates LIN-28 by promoting LIN-28 protein degradation. lep-2 encodes the sole C. elegans ortholog of the Makorin (Mkrn) family of proteins. Like lin-28 and other heterochronic pathway members, vertebrate Mkrns are involved in developmental switches, including the timing of pubertal onset in humans. Based...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (23): 4631–4641.
Published: 1 December 2006
... characteristic of larval molting as they initiate a supernumerary molt. mir-84 and let-7 promote exit from the molting cycle by regulating targets in the heterochronic pathway and also nhr-23 and nhr-25 , genes encoding conserved nuclear hormone receptors essential for larval molting. The synergistic action...
Includes: Supplementary data