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Keywords: Hes1
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Journal Articles
Journal: Development
Development (2021) 148 (4): dev189191.
Published: 17 February 2021
... signaling is a key regulator of stem cell properties in the developing and postnatal brain, and Hes1 is a major effector that strongly inhibits neuronal differentiation and maintains NSCs. To manipulate Hes1 expression levels in NSCs, we generated transgenic (Tg) mice using the Tet-On system. In Hes1...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (4): dev182204.
Published: 26 February 2020
...Shohei Ochi; Yui Imaizumi; Hiromi Shimojo; Hitoshi Miyachi; Ryoichiro Kageyama ABSTRACT The expression of the transcriptional repressor Hes1 oscillates in many cell types, including neural progenitor cells (NPCs), but the significance of Hes1 oscillations in development is not fully understood...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev163568.
Published: 3 September 2018
...Mette C. Jørgensen; Kristian H. de Lichtenberg; Caitlin A. Collin; Rasmus Klinck; Jeppe H. Ekberg; Maja S. Engelstoft; Heiko Lickert; Palle Serup ABSTRACT Mutations in Hes1 , a target gene of the Notch signalling pathway, lead to ectopic pancreas by a poorly described mechanism. Here, we use...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (14): 2488–2499.
Published: 15 July 2012
... induces expression of the Ngn3 repressor Hes1. At the transition from high to intermediate Notch activity, only Sox9, but not Hes1, is maintained, thus de-repressing Ngn3 and initiating endocrine differentiation. In the absence of Sox9 activity, endocrine and ductal cells fail to differentiate, resulting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (1): 33–45.
Published: 1 January 2012
...Jonas Ahnfelt-Rønne; Mette C. Jørgensen; Rasmus Klinck; Jan N. Jensen; Ernst-Martin Füchtbauer; Tye Deering; Raymond J. MacDonald; Chris V. E. Wright; Ole D. Madsen; Palle Serup Neurog3-induced Dll1 expression in pancreatic endocrine progenitors ostensibly activates Hes1 expression via Notch...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (15): 3225–3233.
Published: 1 August 2011
... Mesoderm Notch Hes1 Mouse The union of gut endoderm and splanchnic mesoderm generates the digestive tract and its derivatives – the liver, pancreas and bile ducts ( Wells and Melton, 1999 ). Beneath the specialized epithelia in these organs, cells of mesodermal origin produce fibroblasts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (3): 431–441.
Published: 1 February 2011
..., Notch and its target gene Hes1 are thought to inhibit endocrine and exocrine specification. Although differentiated cells appear to downregulate Hes1 , it is unknown whether Hes1 expression marks multipotent progenitors, or else lineage-restricted precursors. Moreover, although rare cells of the adult...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (9): 1461–1471.
Published: 1 May 2010
... allocation. Finally, Hes1 was identified as an RBPjκ-dependent Notch target gene important for MPC maintenance and the suppression of in vitro chondrogenesis. References Akiyama H. , Chaboissier M. C. , Martin J. F. , Schedl A. , de Crombrugghe B. ( 2002 ). The transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (5): 825–833.
Published: 1 March 2010
... to be a downstream target of Alk5 in vivo and in vitro. Loss of Alk5 -mediated signaling also stimulated Pten gene expression and inhibited ERK phosphorylation in vivo. Using lung epithelial cells, we show that Alk5 -regulated Hes1 expression is stimulated through Pten and the MEK/ERK and PI3K/AKT pathways. Thus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3745–3753.
Published: 15 November 2008
... provided by Tom Gridley,and for Hes1, Hes3 and Hes5 , from plasmids kindly provided by Tom Vogt. RNA probes were synthesized using the DIG RNA labeling kit(Roche) following manufacturer's instructions. β-Gal staining was performed as previously described ( Yao et al., 2002 ). Stained gonads were...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (15): 2531–2541.
Published: 1 August 2008
... tissue has not yet been determined. Using mouse embryos and lineage-tracing analysis, we found that the prospective choroid plexus region initially gives rise to Cajal-Retzius cells, specialized neurons that guide neuronal migration. Inactivation of the bHLH repressor genes Hes1,Hes3 and Hes5 upregulated...
Includes: Supplementary data