... asymmetric cell division, progenitors send a Delta-Notch signal to their sibling stem cells. Here, we show that excessive activation of Notch or overexpression of its direct targets of the Hes family causes stem-cell hyperplasias in the Drosophila larval central nervous system, which can progress...

... regeneration. Our analyses revealed that homologs of coe, hes ( hesl-3 ) and sim label progenitors in intact planarians, and following amputation we observed an enrichment of coe + and sim + progenitors near the wound site. RNAi knockdown of coe, hesl-3 or sim led to defects in CNS regeneration, including...

... . Imayoshi I. , Shimogori T. , Ohtsuka T. , Kageyama R. ( 2008 ). Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline . Development 135 , 2531 - 2541 . Irving C. , Mason I. ( 1999 ). Regeneration...

... cell proliferation and inducing differentiation of tumor cells into all types of intestinal epithelial cells, but without affecting the homeostasis of normal crypts owing to genetic redundancy. These results indicated that Hes genes cooperatively regulate intestinal development and homeostasis...

...Kevin C. Barry; Mona Abed; Dorit Kenyagin; Timothy R. Werwie; Olga Boico; Amir Orian; Susan M. Parkhurst Degringolade (Dgrn) encodes a Drosophila SUMO-targeted ubiquitin ligase (STUbL) protein similar to that of mammalian RNF4. Dgrn facilitates the ubiquitylation of the HES protein Hairy, which...

... and enhancer of split (Hes) gene family regulate neurogenesis by inhibiting neuronal differentiation and maintaining neural stem cell pools in non-neurogenic zones. Remarkably, their role in the spatial control of neurogenesis in the ear is unknown. In this study, we identify her9 , a zebrafish ortholog...

... for correspondence (e-mail: mmercola@burnham.org ) 31 8 2006 © 2006. 2006 Notch Hairy-related transcription factor HRT HES Hey Gridlock Atrioventricular canal T-box Tbx During early embryogenesis, the linear heart [HH stage 10 in the chick( Hamburger and Hamilton,1951 ), E8...

... Proliferation Retinal ganglion cells HES ERK Sonic hedgehog (SHH) Chicken The vertebrate retina is an excellent model with which to study molecular mechanisms governing development of multipotent neural progenitor cells in the central nervous system. As development proceeds, retinal...

...Elise Lamar; Chris Kintner The HES family of bHLH repressors plays a key role in regulating the differentiation of neural precursors in the vertebrate embryo. Members of the HES gene family are expressed in neural precursors as targets of the Notch signaling pathway, but how this occurs...

... Center for General and Tumor Immunology,Hadassah Medical School, Jerusalem, Israel 12 11 2003 © 2004. 2004 Rhombic lip Cerebellum Cerebellar granule cells Neurite Notch Delta Jagged Hes Knockout Mouse The highly ordered cytoarchitecture and the relative simplicity...

... of the HES family of repressors may use different mechanisms of repression, with Hairy and E(spl)mδ being strictly dependent on a DNA target site, versus E(spl)m7 and mγretaining activity in the absence of direct DNA binding. To gain more insight into this novel repression mechanism of E(spl)m7 and mγ...

.... and Guillemot , F. ( 1995 ). Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis,and severe neural tube defects . Genes Dev . 15 , 3136 – 3148 . 10.1101/gad.9.24.3136 Jarriault , S...

... 2000 Presomitic mesoderm HES hairy -related genes lunatic fringe Notch signalling Chick Mouse Segmentation of the vertebrate body is a sequential process which leads to the formation of reiterated mesodermal structures called somites. Somitic segmentation provides the frame...