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Keywords: Hematopoietic stem cells
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Journal Articles
Journal: Development
Development (2022) 149 (7): dev200339.
Published: 7 April 2022
...Yukino Wada; Hikaru Tsukatani; Chihiro Kuroda; Yurika Miyazaki; Miku Otoshi; Isao Kobayashi ABSTRACT During development, the somites play a key role in the specification of hematopoietic stem cells (HSCs). In zebrafish, the somitic Notch ligands Delta-c (Dlc) and Dld, both of which are regulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200025.
Published: 11 February 2022
...Laura F. Bennett; Melanie D. Mumau; Yan Li; Nancy A. Speck ABSTRACT Hemogenic endothelial (HE) cells in the dorsal aorta undergo an endothelial-to-hematopoietic transition (EHT) to form multipotent progenitors, lympho-myeloid biased progenitors (LMPs), pre-hematopoietic stem cells (pre-HSCs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200139.
Published: 24 January 2022
... hematopoietic stem cells (HSCs), many TLCs are of fetal origin and poorly generated from adult HSCs. Here, we sought to further understand murine TLC development and the roles of Flk2 and IL7Rα, two cytokine receptors with known function in traditional lymphopoiesis. Using Flk2- and Il7r-Cre lineage tracing, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199498.
Published: 18 January 2022
... , A. , Hills , D. , Zhao , S. , Travers , P. and Medvinsky , A. ( 2017 ). Understanding hematopoietic stem cell development through functional correlation of their proliferative status with the intra-aortic cluster architecture . Stem Cell Reports 8 , 1549 - 1562 . 10.1016/j.stemcr...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (15): dev199373.
Published: 9 August 2021
.... Although it is widely accepted that B1 cells originate early in fetal life, whether or not they arise from hematopoietic stem cells (HSCs) is still unclear. In order to shed light on the B1 cell origin, we set out to determine whether their lineage specification is dependent on Notch signaling, which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (10): dev191924.
Published: 27 May 2021
... major lipid metabolic pathways: the build-up of lipids, called de novo lipogenesis, and the breakdown of lipids, called fatty acid beta-oxidation. We cover the recent literature on hematopoietic stem cells, intestinal stem cells, neural stem/progenitor cells and cancer stem cells, where these two lipid...
Journal Articles
Journal: Development
Development (2020) 147 (1): dev181040.
Published: 8 January 2020
...Isao Kobayashi; Jingjing Kobayashi-Sun; Yuto Hirakawa; Madoka Ouchi; Koyuki Yasuda; Hiroyasu Kamei; Shigetomo Fukuhara; Masaaki Yamaguchi ABSTRACT In order to efficiently derive hematopoietic stem cells (HSCs) from pluripotent precursors, it is crucial to understand how mesodermal cells acquire...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev176180.
Published: 22 July 2019
... in the adult brain . Cell Rep.   18 , 391 - 405 . 10.1016/j.celrep.2016.12.041 Beaudin , A. E. and Forsberg , E. C. ( 2016 ). To B1a or not to B1a: do hematopoietic stem cells contribute to tissue-resident immune cells?   Blood   128 , 2765 - 2769 . 10.1182/blood-2016-10-697813...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev164103.
Published: 21 March 2019
.... and Karlsson , S. ( 2006 ). Smad7 promotes self-renewal of hematopoietic stem cells . Blood   108 , 4246 - 4254 . 10.1182/blood-2006-02-005611 Brayer , K. J. and Segal , D. J. ( 2008 ). Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2352–2363.
Published: 1 July 2017
...Laurent Yvernogeau; Catherine Robin Hematopoietic stem cells (HSCs), which are responsible for blood cell production, are generated during embryonic development. Human and chicken embryos share features that position the chicken as a reliable and accessible alternative model to study developmental...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4571–4581.
Published: 15 December 2016
...Mihaela Crisan; Elaine Dzierzak Not all hematopoietic stem cells (HSCs) are alike. They differ in their physical characteristics such as cell cycle status and cell surface marker phenotype, they respond to different extrinsic signals, and they have different lineage outputs following...
Journal Articles
Journal: Development
Development (2016) 143 (19): 3429–3433.
Published: 1 October 2016
...Anna Bigas; Claudia Waskow In June 2016, around 200 scientists from all over the world gathered at EMBL headquarters in Heidelberg, Germany to discuss the recent advances in hematopoietic stem cells from three different angles: developmental, adulthood and aging. The meeting, aptly named...
Journal Articles
Journal: Development
Development (2016) 143 (1): 3–14.
Published: 1 January 2016
... of Biologists Ltd 2016 Summary: This Review presents the latest advances in our understanding of stem cell aging in multiple tissues, and discusses their implications for lifespan, disease and potential therapies. Age-related diseases Hematopoietic stem cells Multicellular organisms So...
Journal Articles
Journal: Development
Development (2014) 141 (22): 4206–4218.
Published: 15 November 2014
.... * These authors contributed equally to this work ‡ Author for correspondence ( saghi.ghaffari@mssm.edu ) Competing interests The authors declare no competing financial interests. © 2014. Published by The Company of Biologists Ltd 2014 Hematopoietic stem cells ROS Embryonic stem cells...
Journal Articles
Journal: Development
Development (2013) 140 (19): 3977–3985.
Published: 1 October 2013
...Fenghua Zhen; Yahui Lan; Bo Yan; Wenqing Zhang; Zilong Wen Recent studies have shown that nascent hematopoietic stem cells (HSCs) derive directly from the ventral aortic endothelium (VAE) via endothelial to hematopoietic transition (EHT). However, whether EHT initiates from a random...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (19): 3521–3530.
Published: 1 October 2012
...Aurelie Kieusseian; Philippe Brunet de la Grange; Odile Burlen-Defranoux; Isabelle Godin; Ana Cumano Hematopoietic stem cells (HSCs), which are defined by their capacity to reconstitute adult conventional mice, are first found in the dorsal aorta after 10.5 days post coitus (dpc) and in the fetal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (23): 3941–3952.
Published: 1 December 2010
...Tatsuya Sasaki; Chiyo Mizuochi; Yuka Horio; Kazuki Nakao; Koichi Akashi; Daisuke Sugiyama Hematopoietic stem cells (HSCs) emerge from and expand in the mouse placenta at mid-gestation. To determine their compartment of origin and define extrinsic signals governing their commitment to this lineage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (10): 1853–1862.
Published: 15 May 2008
... shown that zebrafish EMPs arise in the posterior blood island independently from hematopoietic stem cells (HSCs). In this report, we demonstrate that a fourth wave of hematopoietic precursors arises slightly later in the zebrafish aorta/gonad/mesonephros (AGM) equivalent. We have identified...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (1): 203–213.
Published: 1 January 2005
... population. FSC, forward scatter.(E) Comparison of the hematopoietic labeling of vav ancestry and lysozyme ancestry mice. The circles represent cell compartments: L, lymphoid; M,myelomonocytic and HSC, hematopoietic stem cells. Yellow indicates that the cells in a given compartment are YFP labeled, grey...