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Keywords: Hematopoiesis
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Journal Articles
Journal: Development
Development (2022) 149 (24): dev200919.
Published: 14 December 2022
...Xue Zhang; Yuxi Yang; Yuxuan Wei; Qingshun Zhao; Xin Lou ABSTRACT Hematopoiesis is a highly coordinated process that generates all the body's blood cells, and perturbations in embryonic hematopoiesis may result in illnesses ranging from fetal anemia to various leukemias. Correct establishment...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (19): dev200881.
Published: 30 September 2022
... lineages and is involved in hematopoietic stem/progenitor cell and myeloid cell development in zebrafish. Zebrafish Hematopoiesis Hematopoietic stem/progenitor cells ETS transcription factors National Key Research and Development Program of China 2018YFA0800200 Shenzhen Bay...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (16): dev200534.
Published: 17 August 2022
... no competing or financial interests. 18 1 2022 7 7 2022 © 2022. Published by The Company of Biologists Ltd 2022 Summary: Csf1rb, a zebrafish homolog of mammalian CSF1R, regulates definitive hematopoiesis by modulating the proliferation of hematopoietic stem/progenitor cells...
Includes: Supplementary data
Journal Articles
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Human development
Journal: Development
Development (2022) 149 (8): dev200016.
Published: 3 May 2022
... as important determinants of organ homeostasis, tissue repair, remodeling and regeneration. Although the ontogeny and function of tissue-resident macrophages has been identified as distinct from postnatal hematopoiesis, the inability to specify, in vitro , similar populations that recapitulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200200.
Published: 22 April 2022
...Donn A. Van Deren; Shrutokirti De; Ben Xu; Kayla M. Eschenbacher; Shuhua Zhang; Mario R. Capecchi ABSTRACT Previously, we have demonstrated that a subpopulation of microglia, known as Hoxb8 microglia, is derived from the Hoxb8 lineage during the second wave (E8.5) of yolk sac hematopoiesis, whereas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200139.
Published: 24 January 2022
... with TLC numbers in situ . Taken together, our data defined Flk2- and IL7Rα-positive TLC differentiation paths, and revealed functional roles of Flk2 and IL7Rα in TLC establishment. Fig. 7. Model summary of Flk2- and IL7R-mediated effects on hematopoiesis. (A) The Flk2 and IL7R effects on downstream...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199498.
Published: 18 January 2022
... differentiation protocols. The role of VEGFC in hematopoiesis is still emerging and a few studies in mice have uncovered hematopoietic phenotypes. Recent studies have shown a role for Vegfc and Ccbe1 in FL erythropoiesis ( Fang et al., 2016 ; Zou et al., 2013 ). Ccbe1-deficient mice are anemic, with impaired...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199779.
Published: 22 December 2021
... to be a crucial and under-appreciated determinant of cell-fate decision-making during hematopoiesis. Cell fate Hematopoiesis Mathematical modeling Gene regulatory network Bistability University of Southern California http://dx.doi.org/10.13039/100006034 National Science Foundation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev200216.
Published: 17 December 2021
.... , Goins , L. M. and Spratford , C. M. ( 2019 ). Drosophila as a genetic model for hematopoiesis . Genetics 211 , 367 - 417 . 10.1534/genetics.118.300223 Benmimoun , B. , Polesello , C. , Haenlin , M. and Waltzer , L. ( 2015 ). The EBF transcription factor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev197319.
Published: 15 April 2021
...). Our results support that YY1 PcG function/REPO domain is selectively required for B and T cell development and is unnecessary for myeloid lineage. Fig. 4. A lineage-specific requirement for YY1 PcG function/REPO domain in adult hematopoiesis. (A) Experimental strategy: Yy1 f/f Mx1-Cre bone...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2021) 148 (1): dev194241.
Published: 11 January 2021
... microglial waves, we uncover non-overlapping roles for csf1ra and csf1rb in hematopoiesis, and identified csf1rb as an essential regulator of adult microglia development. Notably, we demonstrate that csf1rb positively regulates HSC-derived myelopoiesis, resulting in macrophage deficiency, including microglia...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (1): dev177022.
Published: 3 January 2020
... taxa. Here, we demonstrate novel PSEDN roles in vivo in Drosophila hematopoiesis and in human erythropoiesis in vitro . Using Drosophila genetics, we show that PSEDN members function with GATA to block lamellocyte differentiation and maintain the prohemocyte pool. Overexpression of human SIX1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev148296.
Published: 5 September 2019
....2321 Aikawa , Y. , Nguyen , L. A. , Isono , K. , Takakura , N. , Tagata , Y. , Schmitz , M. L. , Koseki , H. and Kitabayashi , I. ( 2006 ). Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation . EMBO J...
Journal Articles
Journal: Development
Development (2019) 146 (7): dev166819.
Published: 4 April 2019
...Rohan J. Khadilkar; Guy Tanentzapf ABSTRACT Hematopoiesis requires coordinated cell signals to control the proliferation and differentiation of progenitor cells. In Drosophila , blood progenitors, called prohemocytes, which are located in a hematopoietic organ called the lymph gland, are regulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev158162.
Published: 29 January 2018
.... , Conway , S. J. , McGrath , K. E. and Palis , J. ( 2015 ). Definitive hematopoiesis in the Yolk Sac emerges from Wnt-responsive hemogenic endothelium independently of circulation and arterial identity . Stem Cells   34 , 431 - 444 . 10.1002/stem.2213 Goldie , L. C. , Lucitti...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2415–2427.
Published: 1 July 2017
...Chen U. Zhang; Ken M. Cadigan The lymph gland (LG) is a major source of hematopoiesis during Drosophila development. In this tissue, prohemocytes differentiate into multiple lineages, including macrophage-like plasmatocytes, which comprise the vast majority of mature hemocytes. Previous studies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1441–1449.
Published: 15 April 2017
... hematopoiesis. Because the rescue of normal larval hematopoiesis by H2AV CT was incomplete, we wondered whether this mutant protein might itself have a dominant phenotype. Expression of H2AV CT protein altered the normally WT lymph gland phenotype of His2Av 810 /+ larvae ( Fig. 6 A,D). H2AV CT caused...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4571–4581.
Published: 15 December 2016
... heterogeneity affects leukemogenesis or treatment options. This Review provides a developmental overview of HSC subtypes during embryonic, fetal and adult stages of hematopoiesis and discusses the possible origins and consequences of HSC heterogeneity. We thank members of the E.D. lab for helpful discussions...
Journal Articles
Journal: Development
Development (2016) 143 (8): 1302–1312.
Published: 15 April 2016
... target of AML1 (RUNX1) in adult mouse hematopoiesis . Nat. Genet.   40 , 51 - 60 . 10.1038/ng.2007.7 Huber , T. L. , Kouskoff , V. , Fehling , H. J. , Palis , J. and Keller , G. ( 2004 ). Haemangioblast commitment is initiated in the primitive streak of the mouse embryo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3198–3209.
Published: 15 September 2015
... results suggest that hematopoietic activity is enriched within the A 50 /B 40 relative to A 100 /B 5 ECs, consistent with the primary origin of embryonic hematopoiesis from posterior mesoderm. Studies have suggested that cardiac and hemogenic-endothelial lineages are closely related...
Includes: Supplementary data