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Keywords: Hemangioblast
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Journal Articles
Journal: Development
Development (2015) 142 (19): 3307–3320.
Published: 1 October 2015
... the specification of mesodermal progenitors to hematopoiesis. Gastrulation Hemangioblast Mesoderm At the early stages of embryonic development, the multipotent epiblast gives rise to the three germ layers which are subsequently specified to form all tissues of the developing organism ( Tam...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (13): 2833–2843.
Published: 1 July 2011
... was initiated 1 hour after plating and continued at 10-minute intervals, except for Movie 6 in the supplementary material , which was performed 24 hours after plating. Hemangioblast Hemogenic endothelium Serum-free differentiation Single cell colonial differentiation Time-lapse microscopy...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 595–603.
Published: 15 February 2009
..., A., Goitsuka, R., Pouget, C., Dunon, D. and Jaffredo,T. ( 2002 ). Expression of Notch genes and their ligands during gastrulation in the chicken embryo. Mech. Dev. 116 , 161 -164. Chen, V. C., Stull, R., Joo, D., Cheng, X. and Keller, G. ( 2008 ). Notch signaling respecifies the hemangioblast...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (20): 3447–3458.
Published: 15 October 2008
... the embryonic stem cell differentiation system to investigate the regulation of primitive erythroid development at the level of the hemangioblast. We show that the combination of Wnt signaling with inhibition of the Notch pathway is required for the development of this lineage. Inhibition of Notch signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (8): 1525–1535.
Published: 15 April 2008
... the selective and efficient differentiation of mouse ES cells to hematopoiesis. Each of these factors appears to regulate a step of the process: Bmp4 promotes the very efficient formation of mesoderm; bFGF and activin A induce the differentiation of these mesodermal precursors to the hemangioblast fate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (16): 3041–3048.
Published: 15 August 2007
... of the hemangioblast, an embryonic progenitor of the hematopoietic and endothelial lineages. Eng -/- , Eng +/- and Eng +/+ mouse embryonic stem (ES) cells were differentiated as embryoid bodies (EBs) and assayed for blast colony-forming cells (BL-CFCs). Our results showed a profound reduction in hemangioblast...
Journal Articles
Journal: Development
Development (2007) 134 (2): 393–405.
Published: 15 January 2007
... mechanisms, we compared gene expression profiles between embryonic stem (ES) cell-derived hemangioblasts (Blast-Colony-Forming Cells, BL-CFCs)and their differentiated progeny, Blast cells. Bioinformatic analysis indicated that BL-CFCs resembled other stem cell populations. A role for Gata2 , one of the BL...
Journal Articles
Journal: Development
Development (2006) 133 (14): 2771–2779.
Published: 15 July 2006
...Chie Furuta; Hideo Ema; Shin-ichiro Takayanagi; Takunori Ogaeri; Daiji Okamura; Yasuhisa Matsui; Hiromitsu Nakauchi Vasculogenesis and hematopoiesis are thought to arise in hemangioblasts,the common progenitors of cells in vessels and in blood. This scheme was challenged by kinetic analysis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (18): 4623–4634.
Published: 15 September 2004
... in blood cell and vessel development. We demonstrate that hypoxia accelerates the expression of Brachyury (a mesoderm-specific transcription factor), BMP4 (a mesoderm-promoting growth factor) and FLK1 (a marker of hemangioblasts, the bipotential progenitor of endothelial and hematopoietic cells...
Journal Articles
Journal: Development
Development (2003) 130 (17): 4217–4227.
Published: 1 September 2003
...Hans Jörg Fehling; Georges Lacaud; Atsushi Kubo; Marion Kennedy; Scott Robertson; Gordon Keller; Valerie Kouskoff The hematopoietic and endothelial lineages derive from mesoderm and are thought to develop through the maturation of a common progenitor, the hemangioblast. To investigate...
Journal Articles
Journal: Development
Development (2002) 129 (23): 5511–5520.
Published: 1 December 2002
...Yun Shin Chung; Wen Jie Zhang; Elizabeth Arentson; Paul D. Kingsley; James Palis; Kyunghee Choi Accumulating studies support the idea that a common progenitor, termed the hemangioblast, generates both hematopoietic and endothelial cell lineages. To better define the relationship between these cell...
Journal Articles
Journal: Development
Development (2002) 129 (8): 2015–2030.
Published: 15 April 2002
... hematopoietic precursors. The block in definitive hematopoiesis is similar to that observed in Runx1 knockout mice, implying that zebrafish Runx1 has a function equivalent to that in mammals. Our data suggest that zebrafish Runx1 functions in both blood and vessel development at the hemangioblast level...