...Ezra Lencer; Addison Rains; Erin Binne; Rytis Prekeris; Kristin B. Artinger ABSTRACT The transmembrane proteins cdon and boc are implicated in regulating hedgehog signaling during vertebrate development. Recent work showing roles for these genes in axon guidance and neural crest cell migration...

... understood. Here, we report that the telencephalon-specific loss of PAR3 before the start of neurogenesis leads to increased NPC proliferation at the expense of neurogenesis, resulting in disorganized tissue architecture. These NPCs demonstrate hyperactivation of hedgehog signaling in a smoothened-dependent...

... that the original work is properly attributed. Highlighted Article: The MMM complex is a module that attenuates Hedgehog signaling, regulating left-right asymmetry of organs as well as patterning and morphogenesis of multiple tissues in the embryo. Hedgehog signaling Smoothened Gene-environment...

... pathway by both cell-autonomous and non-autonomous mechanisms. Intestinal stem cell Wnt signaling Mesenchymal cell Hedgehog signaling MAPK Adult stem cells are crucial for cell proliferation and regeneration of differentiated cells during tissue homeostasis. The intestinal epithelium...

... in development and disease. Cholesterol Hedgehog signaling Morphogen Patched Primary cilium Smoothened Secreted hedgehog (HH) ligands are paracrine signaling factors that mediate communication between cells over distances as large as several hundred microns ( Lewis et al., 2001 ). The first...

... Sox9 Gli1 Progenitor cell Hedgehog signaling R26R - Confetti Mouse Summary: During the development of migrating entheses, one progenitor population establishes a simple embryonic tissue, whereas another population is responsible for its postnatal maturation into a complex structure. ©...

.... Hedgehog signaling Coloboma Eye Morphogenesis Ptch2 Zebrafish During eye development, cells and tissues must undergo dynamic movements to generate the complex, precise three-dimensional architecture that is crucial for its function. The embryonic structure of the eye is initially established...

... and anterior/posterior compartment boundary maintenance in vivo in Drosophila melanogaster . Drosophila melanogaster Wing patterning Hedgehog signaling Cardin–Weintraub motif Hedgehog morphogen family members are essential determinants of metazoan body plans. In Drosophila melanogaster...

... interests The authors declare no competing or financial interests. 21 2 2018 12 7 2018 © 2018. Published by The Company of Biologists Ltd 2018 http://www.biologists.com/user-licence-1-1/ Summary: Activation of hedgehog signaling contributes to the joint calcification...

... of Nodal, regulates Gli to mediate gill slit penetration. Pharyngeal patterning Gill slit development Nodal signaling Hedgehog signaling Branchiostoma In bilateral animals, some organs are often arrayed asymmetrically about the midline. For example, in vertebrates, the viscera...

... . Dev. Biol.   379 , 167 - 181 . 10.1016/j.ydbio.2013.04.015 Zadorozny , E. V. , Little , J. C. and Kalderon , D. ( 2015 ). Contributions of Costal 2-Fused interactions to Hedgehog signaling in Drosophila . Development   142 , 931 - 942 . 10.1242/dev.112904 Zhu , C.-H...

... 2017 http://www.biologists.com/user-licence-1-1/ Summary: IFT56 is key for the integrity and function of intraflagellar transport in cilia, and, consequently, for vertebrate development. IFT56 TTC26 Cilia Intraflagellar transport IFTB Hedgehog signaling Microtubule structure...

... and branching, but did not phenocopy transgenic expression of activated smoothened ( SmoM2 ). The epithelium showed no evidence of canonical hedgehog signaling, and hyperproliferation was not blocked by smoothened (SMO) inhibition, suggesting a non-canonical function of PTCH1. Consistent with this possibility...

... article: In the regenerating zebrafish fin, local Hedgehog signalling between basal epidermal cells and osteoblast progenitors controls ray branching and hence skeletal patterning. Zebrafish Caudal fins Regeneration Ray branching Bone patterning Hedgehog signaling Sonic hedgehog Indian...

... dysregulates transcription of the Hedgehog-related genes wrt-8 and grl-16 , the overexpression of which is sufficient to induce the axonal defects. Deficiency of either wrt-8 or grl-16 , or reduced expression of homologs of genes promoting Hedgehog signaling, restores correct axon guidance in jmjd-1.2 mutants...

.... Hedgehog signaling Sufu Rusc Gli Xenopus Mouse Human The Hedgehog (Hh) signaling pathway is evolutionarily conserved and involved in a wide variety of processes during embryogenesis and adult tissue homeostasis ( Jiang and Hui, 2008 ; Hui and Angers, 2011 ; Briscoe and Therond, 2013...

... processing, disrupting HH-dependent hair follicle morphogenesis, but cilia structure is preserved. Intraflagellar transport Ift27 Hedgehog signaling Cilia Hair follicle Skin Mouse The development of the skin starts with the commitment of single-layered surface ectoderm to stratification...

...Jinling Liu; Huiqing Zeng; Aimin Liu Hedgehog signaling is crucial for vertebrate development and physiology. Gli2, the primary effector of Hedgehog signaling, localizes to the tip of the primary cilium, but the importance of its ciliary localization remains unclear. We address the roles of Gli2...

... dependent (see Box 2 ). * Author for correspondence ( joynera@mskcc.org ) Competing interests The authors declare no competing financial interests. © 2014. Published by The Company of Biologists Ltd 2014 Adult stem cells Hedgehog signaling Homeostasis During vertebrate...

... found disruptions in Hedgehog signaling. Post-translational processing of GLI2 and GLI3 was aberrant in the developing facial prominences. Although both GLI2 and GLI3 processing were disrupted in talpid 2 mutants, only GLI3 activator levels were significantly altered in the nucleus. Through additional...