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Keywords: Hedgehog signaling
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Journal Articles
Journal: Development
Development (2021) 148 (19): dev199867.
Published: 04 October 2021
... network . Development 135 , 2489 - 2503 . 10.1242/dev.009324 Dorn , K. V. , Hughes , C. E. and Rohatgi , R. ( 2012 ). A smoothened-Evc2 complex transduces the hedgehog signal at primary cilia . Dev. Cell 23 , 823 - 835 . 10.1016/j.devcel.2012.07.004 Durkin , M...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev185678.
Published: 02 September 2020
... pathway by both cell-autonomous and non-autonomous mechanisms. Intestinal stem cell Wnt signaling Mesenchymal cell Hedgehog signaling MAPK Adult stem cells are crucial for cell proliferation and regeneration of differentiated cells during tissue homeostasis. The intestinal epithelium...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (10): dev166892.
Published: 15 May 2019
... and converts it to a repressor . Cell   89 , 1043 - 1053 . 10.1016/S0092-8674(00)80292-5 Bangs , F. and Anderson , K. V. ( 2017 ). Primary cilia and mammalian hedgehog signaling . Cold Spring Harb. Perspect. Biol.   9 , a028175 . 10.1101/cshperspect.a028175 Barzi , M...
Journal Articles
Journal: Development
Development (2018) 145 (24): dev165381.
Published: 18 December 2018
... ). Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning . Cell   118 , 505 - 516 . 10.1016/j.cell.2004.07.023 Akiyama , H. , Kim , J.-E. , Nakashima , K. , Balmes , G. , Iwai , N. , Deng , J. M. , Zhang , Z. , Martin , J...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (22): dev165068.
Published: 19 November 2018
.... , Fischer , N. , Rastegar , S. and Strähle , U. ( 2007 ). Cooperation of sonic hedgehog enhancers in midline expression . Dev. Biol.   301 , 578 - 589 . 10.1016/j.ydbio.2006.11.004 Evangelista , M. , Tian , H. and de Sauvage , F. J. ( 2006 ). The hedgehog signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev167221.
Published: 21 September 2018
... and CiM FF-2015-02). References Alcedo , J. , Ayzenzon , M. , Von Ohlen , T. , Noll , M. and Hooper , J. E. ( 1996 ). The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal . Cell   86 , 221 - 232 . 10.1016...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev164830.
Published: 20 September 2018
...@hsdm.harvard.edu ) Competing interests The authors declare no competing or financial interests. 21 2 2018 12 7 2018 © 2018. Published by The Company of Biologists Ltd 2018 http://www.biologists.com/user-licence-1-1/ Summary: Activation of hedgehog signaling contributes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev162586.
Published: 06 August 2018
... of Nodal, regulates Gli to mediate gill slit penetration. Pharyngeal patterning Gill slit development Nodal signaling Hedgehog signaling Branchiostoma In bilateral animals, some organs are often arrayed asymmetrically about the midline. For example, in vertebrates, the viscera...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (14): 2584–2594.
Published: 15 July 2017
... the maintenance, differentiation and proliferation of somatic and germline stem cells of the Drosophila germarium. Yorkie Hedgehog signaling Stem cell niche Drosophila ovary Escort cell The physiological function of stem cells is to support tissue regeneration throughout adult life...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1544–1553.
Published: 15 April 2017
.... and Weatherbee , S. D. ( 2012 ). Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling . Dev. Biol.   368 , 382 - 392 . 10.1016/j.ydbio.2012.06.008 Cole , D. G. , Diener , D. R. , Himelblau , A. L. , Beech , P. L...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1165–1176.
Published: 01 April 2017
... article: In the regenerating zebrafish fin, local Hedgehog signalling between basal epidermal cells and osteoblast progenitors controls ray branching and hence skeletal patterning. Zebrafish Caudal fins Regeneration Ray branching Bone patterning Hedgehog signaling Sonic hedgehog Indian...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1317–1327.
Published: 01 April 2017
... and branching, but did not phenocopy transgenic expression of activated smoothened ( SmoM2 ). The epithelium showed no evidence of canonical hedgehog signaling, and hyperproliferation was not blocked by smoothened (SMO) inhibition, suggesting a non-canonical function of PTCH1. Consistent with this possibility...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (5): 856–865.
Published: 01 March 2017
... dysregulates transcription of the Hedgehog-related genes wrt-8 and grl-16 , the overexpression of which is sufficient to induce the axonal defects. Deficiency of either wrt-8 or grl-16 , or reduced expression of homologs of genes promoting Hedgehog signaling, restores correct axon guidance in jmjd-1.2 mutants...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3944–3955.
Published: 01 November 2016
.... Hedgehog signaling Sufu Rusc Gli Xenopus Mouse Human Rusc2 was identified from a yeast two-hybrid screen using full-length Sufu as bait. To verify the interaction between Sufu and Rusc2, we performed a co-immunoprecipitation (CoIP) in HEK293T cells. We were able to co-immunoprecipitate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (12): 2194–2202.
Published: 15 June 2015
...@stonybrook.edu ) Competing interests The authors declare no competing or financial interests. 11 7 2014 1 5 2015 © 2015. Published by The Company of Biologists Ltd 2015 Intraflagellar transport Ift27 Hedgehog signaling Cilia Hair follicle Skin Mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1651–1660.
Published: 01 May 2015
...Jinling Liu; Huiqing Zeng; Aimin Liu Hedgehog signaling is crucial for vertebrate development and physiology. Gli2, the primary effector of Hedgehog signaling, localizes to the tip of the primary cilium, but the importance of its ciliary localization remains unclear. We address the roles of Gli2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (18): 3445–3457.
Published: 15 September 2014
... , J. , Dessaud , E. , Sasai , N. , Page , K. M. , Briscoe , J. and Ribes , V. ( 2012 ). Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube . Cell 148 , 273 - 284 . 10.1016/j.cell.2011.10.047 Balordi , F...
Journal Articles
Journal: Development
Development (2014) 141 (15): 3003–3012.
Published: 01 August 2014
... found disruptions in Hedgehog signaling. Post-translational processing of GLI2 and GLI3 was aberrant in the developing facial prominences. Although both GLI2 and GLI3 processing were disrupted in talpid 2 mutants, only GLI3 activator levels were significantly altered in the nucleus. Through additional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (18): 3848–3857.
Published: 15 September 2013
... M. W. ( 2008 ). Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans . J. Neurosci. 28 , 7350 – 7358 . Hamaguchi K. , Yamamoto N. , Nakagawa T. , Furuyashiki T. , Narumiya S. , Ito J. ( 2012 ). Role of PGE-type...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2371–2380.
Published: 01 July 2012
... no competing financial interests. 23 4 2012 © 2012. Dermal bone Hedgehog signaling Modularity Morphogenesis Skeletogenesis Zebrafish During formation of the skeleton, bones and cartilages with unique morphologies are produced to provide structural support...
Includes: Multimedia, Supplementary data