... . Circulation 113 , 2097 - 2104 . 10.1161/CIRCULATIONAHA.105.595231 Del Re , D. P. ( 2014 ). The hippo signaling pathway: implications for heart regeneration and disease . Clin. Transl. Med. 3 , 27 . 10.1186/s40169-014-0027-0 Dhanantwari , P. , Lee , E. , Krishnan...

... is broadly expressed, its disruption had most notable impact on the heart and at juvenile stages. Our findings reveal context-dependent requirements for translation initiation regulators during heart regeneration. * Author for correspondence ( aaron.goldman@osumc.edu ) Handling Editor: Benoit...

... and reproduction in any medium provided that the original work is properly attributed. Summary: This study highlights the importance of Foxm1, a transcription factor that is activated in cardiac muscle cells to regulate cell cycle gene expression and cell division in regeneration. Heart regeneration...

...Paige DeBenedittis; Anish Karpurapu; Albert Henry; Michael C. Thomas; Timothy J. McCord; Kyla Brezitski; Anil Prasad; Caroline E. Baker; Yoshihiko Kobayashi; Svati H. Shah; Christopher D. Kontos; Purushothama Rao Tata; R. Thomas Lumbers; Ravi Karra ABSTRACT Heart regeneration requires multiple cell...

... tissue, which in zebrafish enables subsequent regeneration through paracrine and vascularizing effects. To identify tissue regeneration enhancer elements (TREEs) that control injury-induced epicardial gene expression during heart regeneration, we profiled transcriptomes and chromatin accessibility...

... zebrafish heart. The zebrafish genome contains a prrx1a and a prrx1b gene, which are likely the result of an ancient genome duplication that occurred in teleosts ( Howe et al., 2013 ). Our results demonstrate that whereas prrx1b is required for heart regeneration, prrx1a is dispensable, which...

... components in human cardiac development, and discuss emerging evidence of a central role for the ECM in promoting heart regeneration. As the heart gains structural complexity, valves form between chambers and at the OFT to prevent retrograde blood flow. Initiation of valve development is highly...

... and improves the resolution of transient collagen deposition. Through loss- and gain-of-function as well as pharmacological approaches, we provide evidence that Ccn2a is necessary for and promotes heart regeneration by enhancing the expression of pro-regenerative extracellular matrix genes, and by inhibiting...

... and proliferation of pre-existing cardiomyocytes (CMs). Although many mitogenic signals that stimulate zebrafish heart regeneration have been identified, transcriptional programs that restrain injury-induced CM renewal are incompletely understood. Here, we report that mutations in gridlock ( grl ; also known...

... genes as requisite for zebrafish heart regeneration and suggests that repression of similar structural components in the border zone of an infarcted human heart might improve its regenerative capacity. To analyze the cellular consequences of this failed transcriptional repression, we monitored...

... transcription factors Cardiogenesis Epigenetic regulator Heart regeneration Heart disease, the leading cause of death worldwide, arises primarily from loss of or damage to cardiomyocytes – the muscle cells that generate the contractile force of the heart. Cardiomyocyte loss can occur in response...

...: Following heart injury, zebrafish dusp6 mutants show increased cardiomyocyte proliferation and angiogenesis and early downregulation of fibrosis genes, indicating accelerated cardiac repair associated with enhanced signaling via PDGFR and Nrg1/Erbb2. Zebrafish Heart regeneration Cardiac repair...

...Juliane Münch; Dimitrios Grivas; Álvaro González-Rajal; Rebeca Torregrosa-Carrión; José Luis de la Pompa The zebrafish heart regenerates after ventricular damage through a process involving inflammation, fibrotic tissue deposition/removal and myocardial regeneration. Using 3D whole-mount imaging...

...Qi Xiao; Guoxin Zhang; Huijuan Wang; Lai Chen; Shuangshuang Lu; Dejing Pan; Geng Liu; Zhongzhou Yang In the field of heart regeneration, the proliferative potential of cardiomyocytes in postnatal mice is under intense investigation. However, solely relying on immunostaining of proliferation markers...

.... Here, we investigated whether the key cardiac transcription factor GATA4 is required for neonatal mouse heart regeneration. Using the neonatal mouse heart cryoinjury and apical resection models with an inducible loss of GATA4 specifically in cardiomyocytes, we found severely depressed ventricular...

.... Published by The Company of Biologists Ltd 2016 Summary: This Review article discusses the cellular and molecular mechanisms that control cardiomyocyte proliferation, during both heart development and regeneration across various species. Cardiomyocyte Heart regeneration Proliferation...

... heart development and adult cardiac anatomy, but displayed profound defects in injury-induced cardiomyocyte proliferation and heart regeneration. Our study defines a new platform for the discovery of epicardial lineage markers, genetic tools, and mechanisms of heart regeneration. Proliferation...

... microRNA miR-101a during adult zebrafish heart regeneration. We demonstrate that miR-101a expression is rapidly depleted within 3 days post-amputation (dpa) but is highly upregulated by 7-14 dpa, before returning to uninjured levels at the completion of the regenerative process. Employing heat-inducible...

... Heart regeneration Zebrafish have been a valuable model system for vertebrate embryologists for nearly three decades, and the past decade has also seen their widespread use in stem cell and regeneration studies. Zebrafish are highly regenerative as adults, being equipped to regrow tissues...

... infarction. By contrast, zebrafish regenerate heart muscle after trauma by inducing proliferation of spared cardiomyocytes, providing a model for identifying manipulations that block or enhance these events. Although direct genetic or chemical screens of heart regeneration in adult zebrafish present several...