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Keywords: Heart regeneration
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Journal Articles
Journal: Development
Development (2021) 148 (19): dev198937.
Published: 04 October 2021
... Committee of the Instantie voor Dierenwelzijn Utrecht (IvD) and was performed in compliance with the Dutch government guidelines. Zebrafish were housed under standard conditions ( Aleström et al., 2019 ). In conclusion, we have shown that during zebrafish heart regeneration Prrx1b expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev191320.
Published: 05 March 2021
... components in human cardiac development, and discuss emerging evidence of a central role for the ECM in promoting heart regeneration. * Author for correspondence ( e.s.noel@sheffield.ac.uk ) Competing interests The authors declare no competing or financial interests. © 2021. Published...
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193219.
Published: 18 January 2021
... and improves the resolution of transient collagen deposition. Through loss- and gain-of-function as well as pharmacological approaches, we provide evidence that Ccn2a is necessary for and promotes heart regeneration by enhancing the expression of pro-regenerative extracellular matrix genes, and by inhibiting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev190678.
Published: 28 September 2020
... and proliferation of pre-existing cardiomyocytes (CMs). Although many mitogenic signals that stimulate zebrafish heart regeneration have been identified, transcriptional programs that restrain injury-induced CM renewal are incompletely understood. Here, we report that mutations in gridlock ( grl ; also known...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev178632.
Published: 09 October 2019
... genes as requisite for zebrafish heart regeneration and suggests that repression of similar structural components in the border zone of an infarcted human heart might improve its regenerative capacity. H3K27me3 bam files were sorted and filtered with samtools to exclude sam flags 1796...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (24): dev171983.
Published: 20 December 2018
... transcription factors Cardiogenesis Epigenetic regulator Heart regeneration Although the expression of BRG1 is downregulated postnatally, it is reactivated by cardiac stress. In the stressed adult heart, reactivated BRG1 associates with its embryonic partners, HDACs and PARP, to induce a pathological...
Journal Articles
Journal: Development
Development (2018) 145 (5): dev157206.
Published: 06 March 2018
...: Following heart injury, zebrafish dusp6 mutants show increased cardiomyocyte proliferation and angiogenesis and early downregulation of fibrosis genes, indicating accelerated cardiac repair associated with enhanced signaling via PDGFR and Nrg1/Erbb2. Zebrafish Heart regeneration Cardiac repair...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1425–1440.
Published: 15 April 2017
...Juliane Münch; Dimitrios Grivas; Álvaro González-Rajal; Rebeca Torregrosa-Carrión; José Luis de la Pompa The zebrafish heart regenerates after ventricular damage through a process involving inflammation, fibrotic tissue deposition/removal and myocardial regeneration. Using 3D whole-mount imaging...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 580–589.
Published: 15 February 2017
...Qi Xiao; Guoxin Zhang; Huijuan Wang; Lai Chen; Shuangshuang Lu; Dejing Pan; Geng Liu; Zhongzhou Yang In the field of heart regeneration, the proliferative potential of cardiomyocytes in postnatal mice is under intense investigation. However, solely relying on immunostaining of proliferation markers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (6): 936–949.
Published: 15 March 2016
.... Here, we investigated whether the key cardiac transcription factor GATA4 is required for neonatal mouse heart regeneration. Using the neonatal mouse heart cryoinjury and apical resection models with an inducible loss of GATA4 specifically in cardiomyocytes, we found severely depressed ventricular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (5): 729–740.
Published: 01 March 2016
... in cardiovascular research. Here, we review our current understanding of how cardiomyocyte proliferation is regulated during heart development and regeneration. The belief that adult human cardiomyocytes unequivocally lose their ability to divide has historically frustrated hopes for human heart regeneration...
Journal Articles
Journal: Development
Development (2016) 143 (2): 232–243.
Published: 15 January 2016
... heart development and adult cardiac anatomy, but displayed profound defects in injury-induced cardiomyocyte proliferation and heart regeneration. Our study defines a new platform for the discovery of epicardial lineage markers, genetic tools, and mechanisms of heart regeneration. It is likely...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (23): 4026–4037.
Published: 01 December 2015
... microRNA miR-101a during adult zebrafish heart regeneration. We demonstrate that miR-101a expression is rapidly depleted within 3 days post-amputation (dpa) but is highly upregulated by 7-14 dpa, before returning to uninjured levels at the completion of the regenerative process. Employing heat-inducible...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (24): 4988–4997.
Published: 15 December 2013
... Heart regeneration Zebrafish have been a valuable model system for vertebrate embryologists for nearly three decades, and the past decade has also seen their widespread use in stem cell and regeneration studies. Zebrafish are highly regenerative as adults, being equipped to regrow tissues...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (3): 660–666.
Published: 01 February 2013
... infarction. By contrast, zebrafish regenerate heart muscle after trauma by inducing proliferation of spared cardiomyocytes, providing a model for identifying manipulations that block or enhance these events. Although direct genetic or chemical screens of heart regeneration in adult zebrafish present several...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (22): 4133–4142.
Published: 15 November 2012
... show that migration of cardiomyocytes to the injury site is essential for heart regeneration. Ventricular amputation induced expression of cxcl12a and cxcr4b , genes encoding a chemokine ligand and its receptor. We found that cxcl12a was expressed in the epicardial tissue and that Cxcr4 was expressed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (11): 1921–1930.
Published: 01 June 2012
... are spatially and temporally coordinated during heart regeneration in zebrafish. Here, we report that the balance between the reparative and regenerative processes is achieved through Smad3-dependent TGFβ signaling. The type I receptor alk5b ( tgfbr1b ) is expressed in both fibrotic and cardiac cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (16): 3421–3430.
Published: 15 August 2011
...Jinhu Wang; Daniela Panáková; Kazu Kikuchi; Jennifer E. Holdway; Matthew Gemberling; James S. Burris; Sumeet Pal Singh; Amy L. Dickson; Yi-Fan Lin; M. Khaled Sabeh; Andreas A. Werdich; Deborah Yelon; Calum A. MacRae; Kenneth D. Poss Natural models of heart regeneration in lower vertebrates...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2895–2902.
Published: 15 July 2011
... potential of epicardial tissue in zebrafish during both embryonic development and injury-induced heart regeneration. We found that upstream sequences of the transcription factor gene tcf21 activated robust, epicardium-specific expression throughout development and regeneration. Cre recombinase-based...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (9): 1663–1674.
Published: 01 May 2011
... of the mechanisms of scar removal post-MI. Zebrafish Cryoinjury Fibrosis Scar regression Epicardium Heart regeneration We thank the CNIC animal facility and, in particular, Eduardo Díaz for excellent zebrafish husbandry. We are grateful to Enrique Lara-Pezzi and Ignacio Flores for comments...
Includes: Multimedia, Supplementary data