... for epicardium development. Although WT1 is also expressed in coronary endothelial cells (ECs), the abnormal heart development observed in Wt1 knockout mice is mainly attributed to its functions in the epicardium. Here, we have generated an inducible endothelial-specific Wt1 knockout mouse model ( Wt1KO ΔEC...

... change their cell fate into epicardial-like cells. wt1a wt1b Heart development Cardiomyocyte Epicardium Zebrafish Cell fate Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung http://dx.doi.org/10.13039/501100001711 320030E-164245 310030L_182575...

...-tailed unpaired Student's t -test. Although mitochondrial abnormalities can cause heart developmental defects, the importance of mitochondrial quality control for prenatal heart development has not been well documented. Our study shows that the mitochondrial matrix protease LONP1, as a key...

...Christopher J. Derrick; Eric J. G. Pollitt; Ashley Sanchez Sevilla Uruchurtu; Farah Hussein; Andrew J. Grierson; Emily S. Noël ABSTRACT During early vertebrate heart development, the heart transitions from a linear tube to a complex asymmetric structure, a morphogenetic process that occurs...

...: modifications to a complex story . Nat. Rev. Mol. Cell Biol. 16 , 643 - 649 . 10.1038/nrm4067 Bruneau , B. G. ( 2013 ). Signaling and transcriptional networks in heart development and regeneration . Cold Spring Harb Perspect Biol 5 , a008292 . 10.1101/cshperspect.a008292...

...Mingjie Xu; Jie Yao; Yingchao Shi; Huijuan Yi; Wukui Zhao; Xinhua Lin; Zhongzhou Yang ABSTRACT Mammalian heart development relies on cardiomyocyte mitochondrial maturation and metabolism. Embryonic cardiomyocytes make a metabolic shift from anaerobic glycolysis to oxidative metabolism by mid...

... and complex morphogenesis of a linear tube. This Review explores how cardiac extracellular matrix composition changes to support specific processes during heart morphogenesis. Cardiac morphogenesis Extracellular matrix Heart development Heart regeneration Heart development is a highly complex...

... into the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased heart...

... in the cardiac regeneration response to injury. Cardiac neural crest cells Cardiac specification Myocardium Heart development Cardiac regeneration Neural crest cells (NCCs) are a multipotential population of cells unique to vertebrates that arise after delamination from the dorsal-most aspect...

... in heart development . Dev. Biol.   217 , 42 - 53 . 10.1006/dbio.1999.9534 Auman , H. J. , Coleman , H. , Riley , H. E. , Olale , F. , Tsai , H.-J. and Yelon , D. ( 2007 ). Functional modulation of cardiac form through regionally confined cell shape changes . PLoS Biol...

...Andrew Holowiecki; Kelsey Linstrum; Padmapriyadarshini Ravisankar; Kashish Chetal; Nathan Salomonis; Joshua S. Waxman ABSTRACT Vertebrate heart development requires the integration of temporally distinct differentiating progenitors. However, few signals are understood that restrict the size...

... that epicardial heterogeneity is regulated by the transcription factor BNC1 and separates the cells into two populations with different properties. Epicardium Human pluripotent stem cells Heart development Regenerative medicine BNC1 Single cell The epicardium is an epithelium covering the heart...

... computationally identified nine murine lincRNAs that have developmentally regulated transcriptional and epigenomic profiles specific to early heart differentiation. Six of the nine lincRNAs had in vivo expression patterns supporting a potential function in heart development, including a transcript downstream...

... remain challenging. Here, using multiple knockout mouse models and single cell RNA sequencing, we demonstrate that the divergent lncRNA Hand2os1 / Uph has a key complex modulatory effect on the expression of its neighboring gene HAND2 and subsequently on heart development and function. Short deletion...

..., plays key roles in heart development and regeneration. During embryogenesis, the epicardium arises from the proepicardium (PE), a cell cluster that appears in the dorsal pericardium (DP) close to the venous pole of the heart. Little is known about how the PE emerges from the pericardial mesothelium...

...Noelia Muñoz-Martín; Rocío Sierra; Thomas Schimmang; Cristina Villa del Campo; Miguel Torres ABSTRACT Myc is considered an essential transcription factor for heart development, but cardiac defects have only been studied in global Myc loss-of-function models. Here, we eliminated Myc by recombining...

...Natalie Gibb; Savo Lazic; Xuefei Yuan; Ashish R. Deshwar; Meaghan Leslie; Michael D. Wilson; Ian C. Scott ABSTRACT A key event in heart development is the timely addition of cardiac progenitor cells, defects in which can lead to congenital heart defects. However, how the balance and proportion...

... of analytical tools necessary to identify distinct relationships between hemodynamic parameters and the rapidly morphing pharyngeal arch manifold. Aortic arches Chick embryo Computational modeling Heart development Hemodynamics Mechanical forces Congenital heart defects (CHDs) constitute...

...-1/ Summary: Live imaging in zebrafish shows that cardiomyocyte division is preceded by sarcomere disassembly and changes in cell shape and volume, with distinct signaling pathways controlling proliferation of compact and trabecular cardiomyocytes. Heart development Cardiomyocyte...

... heart development reveals its role in compact wall maturation and trabeculation, as well as in modulation of the cardiomyocyte actomyosin network and cell-cell junctions. Heart development Hippo pathway Yap Taz Wwtr1 Trabeculation Cardiac trabeculation is an important step to cardiac...