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Keywords: Heart development
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Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (24): dev201913.
Published: 14 December 2023
... of mouse development. To understand the function of Sall1/4 in heart development, we generated heart-specific Sall1/4 functionally inhibited mice by forced expression of the truncated form of Sall4 (ΔSall4) in the heart. The ΔSall4- overexpression mice exhibited a hypoplastic right ventricle and outflow...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (21): dev201677.
Published: 30 October 2023
... and temporal manner remains unclear. Studies show that Tbx20 directly interacts with the Transducin-like Enhancer of Split (TLE) family of proteins to mediate transcriptional repression. However, a function for the Tbx20-TLE transcriptional repression complex during heart development has yet to be established...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (6): dev201147.
Published: 27 March 2023
... for epicardium development. Although WT1 is also expressed in coronary endothelial cells (ECs), the abnormal heart development observed in Wt1 knockout mice is mainly attributed to its functions in the epicardium. Here, we have generated an inducible endothelial-specific Wt1 knockout mouse model ( Wt1KO ΔEC...
Includes: Supplementary data
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Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (13): dev199628.
Published: 28 June 2021
...: modifications to a complex story . Nat. Rev. Mol. Cell Biol. 16 , 643 - 649 . 10.1038/nrm4067 Bruneau , B. G. ( 2013 ). Signaling and transcriptional networks in heart development and regeneration . Cold Spring Harb Perspect Biol 5 , a008292 . 10.1101/cshperspect.a008292...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (5): dev191320.
Published: 5 March 2021
... and complex morphogenesis of a linear tube. This Review explores how cardiac extracellular matrix composition changes to support specific processes during heart morphogenesis. Cardiac morphogenesis Extracellular matrix Heart development Heart regeneration Heart development is a highly complex...
Journal Articles
Journal: Development
Development (2020) 147 (21): dev194233.
Published: 21 October 2020
... into the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased heart...
Journal Articles
Journal: Development
Development (2020) 147 (20): dev188706.
Published: 15 October 2020
... in the cardiac regeneration response to injury. Cardiac neural crest cells Cardiac specification Myocardium Heart development Cardiac regeneration Neural crest cells (NCCs) are a multipotential population of cells unique to vertebrates that arise after delamination from the dorsal-most aspect...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev185900.
Published: 17 June 2020
... in heart development . Dev. Biol.   217 , 42 - 53 . 10.1006/dbio.1999.9534 Auman , H. J. , Coleman , H. , Riley , H. E. , Olale , F. , Tsai , H.-J. and Yelon , D. ( 2007 ). Functional modulation of cardiac form through regionally confined cell shape changes . PLoS Biol...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (24): dev174441.
Published: 13 December 2019
... that epicardial heterogeneity is regulated by the transcription factor BNC1 and separates the cells into two populations with different properties. Epicardium Human pluripotent stem cells Heart development Regenerative medicine BNC1 Single cell The epicardium is an epithelium covering the heart...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev185314.
Published: 9 December 2019
... computationally identified nine murine lincRNAs that have developmentally regulated transcriptional and epigenomic profiles specific to early heart differentiation. Six of the nine lincRNAs had in vivo expression patterns supporting a potential function in heart development, including a transcript downstream...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174961.
Published: 4 July 2019
..., plays key roles in heart development and regeneration. During embryogenesis, the epicardium arises from the proepicardium (PE), a cell cluster that appears in the dorsal pericardium (DP) close to the venous pole of the heart. Little is known about how the PE emerges from the pericardial mesothelium...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev170753.
Published: 1 February 2019
...Noelia Muñoz-Martín; Rocío Sierra; Thomas Schimmang; Cristina Villa del Campo; Miguel Torres ABSTRACT Myc is considered an essential transcription factor for heart development, but cardiac defects have only been studied in global Myc loss-of-function models. Here, we eliminated Myc by recombining...
Includes: Supplementary data