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Keywords: Heart
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Journal Articles
Journal: Development
Development (2023) 150 (21): dev202054.
Published: 24 October 2023
... is highly expressed in non-myocytes and potently regulates heart development. Ebf1 -deficient hearts display myocardial hypercellularity and reduced cardiomyocyte size, ventricular conduction system hypoplasia, and conduction system disease. Growth abnormalities in Ebf1 knockout hearts are observed as early...
Journal Articles
Journal: Development
Development (2023) 150 (16): dev201896.
Published: 22 August 2023
... is common across evolution. Functions of such polyploidy are essentially unknown. Here, in both Drosophila larvae and human organ donors, we reveal distinct polyploidy levels in cardiac organ chambers. In Drosophila , differential growth and cell cycle signal sensitivity leads the heart chamber to reach...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (10): dev201450.
Published: 22 May 2023
... as an indispensable heart inducer. A detailed analysis of the role of Bmp4 and its effectors Smad1/5, however, was still missing. We show that Bmp4 induces cardiac mesoderm formation in murine embryonic stem cells in vitro . Bmp4 first activates Wnt3 and upregulates Nodal . pSmad1/5 and the WNT effector Tcf3 form...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (2): dev201013.
Published: 19 January 2023
...Xiaofei Li; Callie McLain; Michael S. Samuel; Michael F. Olson; Glenn L. Radice ABSTRACT The cardiomyocyte phenotypic switch from a proliferative to terminally differentiated state results in the loss of regenerative potential of the mammalian heart shortly after birth. Nonmuscle myosin IIB (NM IIB...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (19): dev200701.
Published: 3 October 2022
... is formed by invaginations of the plasma membrane and grows via re-routing of the recycling endosomal pathway. This is achieved by inactivation of other membrane-consuming pathways and a plasma membrane-like molecular signature of the compartment in these highly specialised heart cells. * Present...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2021) 148 (17): dev199307.
Published: 31 August 2021
...) pathway lead to severe brain malformations with variable penetrance due to unknown modifier genes. To identify such modifiers, we established novel congenic mouse models. LRP2-deficient C57BL/6N mice suffer from heart outflow tract defects and holoprosencephaly caused by impaired SHH activity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (16): dev199672.
Published: 23 August 2021
... of new therapies is lagging compared with other fields. One major bottleneck hindering progress is the lack of self-organizing human cardiac models that recapitulate key aspects of human heart development, physiology and disease. Current in vitro cardiac three-dimensional systems are either engineered...
Journal Articles
Journal: Development
Development (2020) 147 (24): dev194019.
Published: 23 December 2020
...Ian J. Begeman; Kwangdeok Shin; Daniel Osorio-Méndez; Andrew Kurth; Nutishia Lee; Trevor J. Chamberlain; Francisco J. Pelegri; Junsu Kang ABSTRACT Heart regeneration in regeneration-competent organisms can be accomplished through the remodeling of gene expression in response to cardiac injury...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (6): dev180844.
Published: 19 March 2020
... of the molecular mechanisms of regeneration. Heart Regeneration Spinal cord Tail Xenopus Appendage The goal of regenerative medicine is to identify novel therapies aimed at stimulating a full regenerative response in humans following injury, disease or during ageing. As such, uncovering...
Journal Articles
Journal: Development
Development (2019) 146 (14): dev177121.
Published: 29 July 2019
.... , Wakker , V. , de Gier-de , V. C. , Anderson , R. H. , Kispert , A. , Moorman , A. F. and Christoffels , V. M. ( 2010 ). Developmental origin, growth, and three-dimensional architecture of the atrioventricular conduction axis of the mouse heart . Circ. Res.   107 , 728 - 736...
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Journal: Development
Development (2017) 144 (5): 866–875.
Published: 1 March 2017
...Jun-yi Zhu; Amy Heidersbach; Irfan S. Kathiriya; Bayardo I. Garay; Kathryn N. Ivey; Deepak Srivastava; Zhe Han; Isabelle N. King miR-1 is a small noncoding RNA molecule that modulates gene expression in heart and skeletal muscle. Loss of Drosophila miR-1 produces defects in somatic muscle...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (9): 1435–1441.
Published: 1 May 2016
...’. As I review here, participants at the workshop revealed how understanding cardiac growth and lineage decisions at their most fundamental level has transformed the strategies in hand that presently energize the prospects for human heart repair. I am grateful to Brian Black and James Martin...
Journal Articles
Journal: Development
Development (2016) 143 (3): 387–397.
Published: 1 February 2016
... to replace the scar and rebuild normal functioning tissue. Here, we address this problem in the context of heart disease, and discuss the origins and characteristics of cardiac fibroblasts, as well as the crucial role that they play in cardiac development and disease. We discuss the dual nature of cardiac...
Journal Articles
Journal: Development
Development (2016) 143 (3): 473–482.
Published: 1 February 2016
...Michael G. Monaghan; Miriam Linneweh; Simone Liebscher; Ben Van Handel; Shannon L. Layland; Katja Schenke-Layland The elucidation of mechanisms in semilunar valve development might enable the development of new therapies for congenital heart disorders. Here, we found differences in proliferation...
Includes: Supplementary data