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Keywords: HNF1β
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Journal Articles
Journal: Development
Development (2018) 145 (12): dev161372.
Published: 8 June 2018
... of in vitro -generated pancreatic explants, we identified the genes encoding the transcription factor Hnf1β and the Wnt-receptor Fzd4/Fzd4s as direct RA target genes. Functional analyses of Hnf1b and Fzd4 / Fzd4s in programmed pancreatic explants and whole embryos revealed their requirement for pancreatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (4): 886–896.
Published: 15 February 2013
... structures. Hepatocyte nuclear factor 1β (HNF1β) is a divergent homeobox transcription factor that is expressed in kidney from the first steps of nephrogenesis. Mutations in HNF1B (OMIM #137920) are frequently found in patients with developmental renal pathologies, the mechanisms of which have not been...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (4): 763–774.
Published: 15 February 2005
... in presumptive ectoderm. Induction of HNF3β by all three GATA factors was abolished when protein synthesis was inhibited, showing that these inductions are indirect. In contrast, whereas induction of Sox17α and HNF1β by GATA4 and 5 was substantially reduced when protein synthesis was inhibited, induction...
Journal Articles
Journal: Development
Development (2002) 129 (8): 1819–1828.
Published: 15 April 2002
... was perturbed in the prenatal period. The morphology of the intrahepatic bile ducts was identical to that seen in mice whose Hnf1β gene has been conditionally inactivated in the liver. HNF1β expression was downregulated in the intrahepatic bile ducts of Hnf6 –/– mice during development. Furthermore, we found...