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Keywords: Guidance
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Journal Articles
Journal: Development
Development (2020) 147 (4): dev183004.
Published: 17 February 2020
... field. This so-far-ignored AMP role involves their filopodia-based interactions with nerve growth cones. In parallel, we report the previously undetected expression of the guidance molecule-encoding genes sidestep and side IV in AMPs. Altogether, our data support the view that Drosophila muscle stem...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (19): 4081–4090.
Published: 1 October 2013
... the preformed DA guides the axon growth of secondary motoneurons. In the present study, we provide evidence that Vegfc functions as a guidance molecule for the axon growth of motoneurons. We found that Vegfr3 was expressed in motoneurons and that forced expression of the Vegfc-trapping (h)VRGFR3 mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (5): 1111–1122.
Published: 1 March 2013
... neurohypophysis exert direct guidance effects on hypothalamic neurosecretory axons. Simultaneously, they promote hypophyseal vascularisation, exerting early direct effects on endothelial cells that are subsequently complemented by indirect effects. Together, our studies suggest a model for the integrated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (19): 4279–4290.
Published: 1 October 2011
... ) Competing interests statement The authors declare no competing financial interests. 21 7 2011 © 2011. TRIM Sea urchin embryo Ectoderm Skeleton biomineralization Morpholino oligonucleotides Primary mesenchyme Cell migration Guidance otp pax2/5/8 sm30...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (11): 1879–1888.
Published: 1 June 2009
... © 2009. 2009 Dorsal root ganglia Guidance Motor axon Neural crest Neuropilins Peripheral nervous system The vertebrate neural crest is a migratory population of multipotent cells that give rise to many derivatives, including neurons and glia of the peripheral nervous system (PNS...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (19): 3281–3290.
Published: 1 October 2008
..., and segregate from each other to form a mosaic of distinct compartments. However, the molecular mechanisms that underlie this time-dependent process of neuronal segregation remain largely unknown. Using a novel organotypic assay, we identified ephrin/Eph family members as guidance cues that regulate matrix...
Journal Articles
Journal: Development
Development (2007) 134 (18): 3251–3257.
Published: 15 September 2007
...Kelly A. Palaisa; Michael Granato One of the earliest guidance decisions for spinal cord motoneurons occurs when pools of motoneurons orient their growth cones towards a common,segmental exit point. In contrast to later events, remarkably little is known about the molecular mechanisms underlying...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (12): 2293–2302.
Published: 15 June 2007
... evidence that localized VEGF acts as both a guidance cue and a differentiation signal, providing a crucial link between the positioning and differentiation of the migrating PMCs and leading to morphogenesis of the embryonic skeleton. Loss-of-function for the VEGF or VEGFR gene was achieved...
Journal Articles
Journal: Development
Development (2007) 134 (11): 2137–2146.
Published: 1 June 2007
...Asha Dwivedy; Frank B. Gertler; Jeffrey Miller; Christine E. Holt; Cecile Lebrand The Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family of proteins is required for filopodia formation in growth cones and plays a crucial role in guidance cue-induced remodeling of the actin cytoskeleton...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (23): 5947–5958.
Published: 1 December 2004
...Claire Y. Bénard; Hania Kébir; Shin Takagi; Siegfried Hekimi The gene mau-2 has been found to be required for the guidance of cellular and axonal migrations along both the anteroposterior and the dorsoventral body axes during the development of the nematode C. elegans . We show that mau-2 encodes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (21): 5253–5261.
Published: 1 November 2004
...Kagayaki Kato; Takahiro Chihara; Shigeo Hayashi The migration of cellular extensions is guided by signals from tissues with which they contact. Many axon guidance molecules regulate growth cone migration by directly regulating actin cytoskeletal dynamics. Secreted morphogens control global patterns...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (11): 2707–2714.
Published: 1 June 2004
... a role for NO in the regulation of pollen tube growth, a fast tip-growing cellular system. Pollen tubes must be precisely oriented inside the anatomically complex female ovary in order to deliver sperm. We hypothesized that NO could play a role in this guidance and tested this hypothesis by challenging...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2001) 128 (22): 4545–4552.
Published: 15 November 2001
... cones to promote axon defasciculation. We identify a family of 14 beat -like genes in Drosophila . In contrast to beat Ia , four novel Beat-family genes encode membrane-bound proteins. Moreover, mutations in each gene lead to much more subtle guidance phenotypes than observed in beat Ia . Genetic...