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Keywords: Gpr177
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Journal Articles

Colonic healing requires Wnt produced by epithelium as well as Tagln + and Acta2 + stromal cells

In collection:
Stem cells & regeneration
Soumyashree Das, Qiang Feng, Iyshwarya Balasubramanian, Xiang Lin, Haoran Liu, Oscar Pellón-Cardenas, Shiyan Yu, Xiao Zhang, Yue Liu, Zhi Wei, Edward M. Bonder, Michael P. Verzi, Wei Hsu, Lanjing Zhang, Timothy C. Wang, Nan Gao
Journal: Development
Development (2022) 149 (1): dev199587.
DOI: https://doi.org/10.1242/dev.199587
Published: 12 January 2022
... that colonic recovery from colitis-like injury depends on multiple Wnt-producing sources. Wntless Wnt Tagln Acta2 Gpr177 Colitis Wound healing Intestinal stem cell National Institutes of Health R01DK102934 R01DE026936 R01DE015654 R01DK119198 R01AT010243 American Cancer...
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Journal Articles

Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche

In collection:
Stem cells & regeneration
Soumyashree Das, Shiyan Yu, Ryotaro Sakamori, Pavan Vedula, Qiang Feng, Juan Flores, Andrew Hoffman, Jiang Fu, Ewa Stypulkowski, Alexis Rodriguez, Radek Dobrowolski, Akihiro Harada, Wei Hsu, Edward M. Bonder, Michael P. Verzi, Nan Gao
Journal: Development
Development (2015) 142 (12): 2147–2162.
DOI: https://doi.org/10.1242/dev.121046
Published: 15 June 2015
... the homeostasis of adult tissues. Wnt signaling is a crucial regulator of the stem cell niche, but the mechanism that governs Wnt ligand delivery in this compartment has not been fully investigated. We identified that Wnt secretion is partly dependent on Rab8a-mediated anterograde transport of Gpr177 (wntless...
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Includes: Supplementary data