1-17 of 17
Keywords: Germ line
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2016) 143 (17): 3061–3073.
Published: 1 September 2016
... that the original work is properly attributed. Summary: This Review article summarizes the latest findings regarding roles for AGO proteins and their associated small RNAs in the male germline, with a particular focus on spermatogenesis. AGO Germ line Mammalian spermatogenesis miRNA MicroRNA...
Journal Articles
Journal: Development
Development (2015) 142 (22): 3902–3911.
Published: 15 November 2015
...Kathryn Atwell; Zhao Qin; David Gavaghan; Hillel Kugler; E. Jane Albert Hubbard; James M. Osborne The Caenorhabditis elegans germ line is an outstanding model system in which to study the control of cell division and differentiation. Although many of the molecules that regulate germ cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (20): 3571–3582.
Published: 15 October 2015
... and adults display smaller germ lines and reduced brood size consistent with a role for XND-1 in germ cell proliferation. Maternal XND-1 proteins are found in the P 4 lineage and are exclusively localized to the nucleus in PGCs, Z2 and Z3. Zygotic XND-1 turns on shortly thereafter, at the ∼300-cell stage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (8): 1396–1406.
Published: 15 April 2015
... heterogeneity Germ line Intestine Lineage tracing Tissue homeostasis In multicellular organisms, groups of cells specialize within tissues and organs to perform specific tasks and functions. In the course of adult life, these functional cells can become exhausted and progressively lost...
Journal Articles
Journal: Development
Development (2014) 141 (19): 3619–3626.
Published: 1 October 2014
... for germ cell identity and function. We propose three roles for poised chromatin in the mammalian germ line: prevention of DNA methylation, maintenance of germ cell identity and preparation for totipotency. We discuss these roles in the context of recently proposed models for germline potency...
Journal Articles
Journal: Development
Development (2014) 141 (16): 3134–3142.
Published: 15 August 2014
... of Biologists Ltd 2014 Germ line PGC CNOT6 CCR4 Nanos Pumilio Transcriptomics Sea urchin Author contributions G.M.W. and S.Z.S. conceived the project; S.Z.S., J.P.C. and A.H. developed FACS methods; S.Z.S. and N.O. performed experiments. A.M.R. performed bioinformatics analyses; T.R...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (9): 1915–1926.
Published: 1 May 2014
... in the germ line, showing clear oocyte enrichment and a similar subcellular localization in the oocyte. Intensity differences appear to be due to different expression levels, nonspecific staining of the Chc antibody and penetration differences between antibodies. (G) Enlarged views of stage 6, 9 and 10...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (20): 3786–3794.
Published: 15 October 2012
...Mamiko Yajima; Gary M. Wessel The process of germ line determination involves many conserved genes, yet is highly variable. Echinoderms are positioned at the base of Deuterostomia and are crucial to understanding these evolutionary transitions, yet the mechanism of germ line specification...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (5): 859–870.
Published: 1 March 2012
... investigated the role of ribosomal protein S6 kinase (S6K) at the intersection of nutrition and the establishment of a stem/progenitor cell population using the C. elegans germ line as a model. We find that rsks-1 (which encodes the worm homolog of mammalian p70S6K) is required germline-autonomously for proper...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3691–3701.
Published: 15 October 2007
... propose that C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions in the germ line and that the transcriptional regulation of components of the central apoptosis machinery is a critical determinant of constitutive germ cell apoptosis in C. elegans...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (19): 3495–3505.
Published: 1 October 2007
... localization at the posterior cortex was greatly diminished. These results indicate that the functions of CYK-4 are temporally and spatially distinct from RGA-3 and RGA-4 (RGA-3/4). RGA-3/4 and CYK-4 also play different roles in controlling LET-502 activation in the germ line, because rga-3/4 (RNAi...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (6): 1071–1080.
Published: 15 March 2007
... College of Osteopathic Medicine, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308,USA. 3 1 2007 © 2007. 2007 Notch Stem cell Germ line Drosophila Ovary Niche Adult tissues undergo continuous cell turnover throughout an organism's lifetime. Stem cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (4): 757–767.
Published: 15 February 2007
... and not detectable on the X chromosomes. This association is not dependent on the autosome-enriched protein MES-4. Focusing on possible roles of MRG-1 in regulating gene expression, we determined that MRG-1 is required to maintain repression in the maternal germ line of transgenes on extrachromosomal arrays...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (19): 3907–3917.
Published: 1 October 2006
... of MES-4 leads to derepression of X-linked genes in the germ line. We discuss how an autosomally associated HMT may participate in silencing genes on the X chromosome, in coordination with the direct silencing effects of the other MES proteins. † Authors for correspondence (e-mail: lbender...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (4): 611–619.
Published: 15 February 2006
..., characteristic aetiology. However, if aak-2 activity absolutely depends on compromised insulin-like signalling, mutations that prevent the appropriate downregulation of insulin-like signalling should also mimic the effect of aak-2 mutations on the germ line during dauer development mediated through...
Journal Articles
Journal: Development
Development (2003) 130 (26): 6625–6634.
Published: 29 December 2003
... in the Drosophila ovary. In the absence of Zpg the stem cell daughter destined to differentiate dies. The zpg phenotype is novel, and we used this phenotype to genetically dissect the process of stem cell maintenance and differentiation. Our findings suggest that germ line stem cells differentiate upon losing...
Journal Articles
Journal: Development
Development (1985) 88 (1): 349–363.
Published: 1 August 1985
... © The Company of Biologists Limited 1985 Clonal analysis of X-chromosome inactivation and the origin of the germ line in the mouse embryo R. L. GARDNER1, M. F. LYON2, E. P. EVANS1 AND M. D. BURTENSHAW1 1Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, U.K. and2 Medical...