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Keywords: Germ line
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Reproductive biology
Journal: Development
Development (2023) 150 (17): dev201472.
Published: 12 September 2023
...Gautam Chandra Sarkar; Umanshi Rautela; Anita Goyala; Sudeshna Datta; Nikhita Anand; Anupama Singh; Prachi Singh; Manish Chamoli; Arnab Mukhopadhyay ABSTRACT Germ line integrity is crucial for progeny fitness. Organisms deploy the DNA damage response (DDR) signaling to protect the germ line from...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (22): 3902–3911.
Published: 15 November 2015
...Kathryn Atwell; Zhao Qin; David Gavaghan; Hillel Kugler; E. Jane Albert Hubbard; James M. Osborne The Caenorhabditis elegans germ line is an outstanding model system in which to study the control of cell division and differentiation. Although many of the molecules that regulate germ cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (20): 3571–3582.
Published: 15 October 2015
... crossover formation consistent with its expression from the mitotic tip of the germ line through the late pachytene region ( Wagner et al., 2010 ). However, the sterility and reduced brood sizes associated with xnd-1 suggest a more pleiotropic role in germline development. Therefore, we set out to examine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (8): 1396–1406.
Published: 15 April 2015
...   110 , 20152 - 20157 . 10.1073/pnas.1311381110 Goriely , A. , McVean , G. A. T. , Röjmyr , M. , Ingemarsson , B. and Wilkie , A. O. M. ( 2003 ). Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line . Science   301 , 643 - 646 . 10.1126...
Journal Articles
Journal: Development
Development (2014) 141 (19): 3619–3626.
Published: 1 October 2014
... for germ cell identity and function. We propose three roles for poised chromatin in the mammalian germ line: prevention of DNA methylation, maintenance of germ cell identity and preparation for totipotency. We discuss these roles in the context of recently proposed models for germline potency...
Journal Articles
Journal: Development
Development (2014) 141 (16): 3134–3142.
Published: 15 August 2014
... of Biologists Ltd 2014 Germ line PGC CNOT6 CCR4 Nanos Pumilio Transcriptomics Sea urchin The germ line provides an immortal link between generations by transmitting heritable information from parent to progeny. Specification of the animal germ line typically occurs during embryogenesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (9): 1915–1926.
Published: 1 May 2014
... compartment. Indeed, a fraction of differently tagged (V5, Myc, Flag and GFP) or un-tagged Chc colocalizes with Bic-D in specific regions of the oocyte ( Fig. 1 D-H; data not shown). The germ line Chc signal became enriched in the oocyte from early stages onwards ( Fig. 1 D,F) and further signal enrichment...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (20): 3786–3794.
Published: 15 October 2012
...Mamiko Yajima; Gary M. Wessel The process of germ line determination involves many conserved genes, yet is highly variable. Echinoderms are positioned at the base of Deuterostomia and are crucial to understanding these evolutionary transitions, yet the mechanism of germ line specification...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (5): 859–870.
Published: 1 March 2012
... investigated the role of ribosomal protein S6 kinase (S6K) at the intersection of nutrition and the establishment of a stem/progenitor cell population using the C. elegans germ line as a model. We find that rsks-1 (which encodes the worm homolog of mammalian p70S6K) is required germline-autonomously for proper...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3691–3701.
Published: 15 October 2007
... propose that C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions in the germ line and that the transcriptional regulation of components of the central apoptosis machinery is a critical determinant of constitutive germ cell apoptosis in C. elegans...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (19): 3495–3505.
Published: 1 October 2007
... localization at the posterior cortex was greatly diminished. These results indicate that the functions of CYK-4 are temporally and spatially distinct from RGA-3 and RGA-4 (RGA-3/4). RGA-3/4 and CYK-4 also play different roles in controlling LET-502 activation in the germ line, because rga-3/4 (RNAi...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (6): 1071–1080.
Published: 15 March 2007
... College of Osteopathic Medicine, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308,USA. 3 1 2007 © 2007. 2007 Notch Stem cell Germ line Drosophila Ovary Niche Adult tissues undergo continuous cell turnover throughout an organism's lifetime. Stem cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (4): 757–767.
Published: 15 February 2007
... and not detectable on the X chromosomes. This association is not dependent on the autosome-enriched protein MES-4. Focusing on possible roles of MRG-1 in regulating gene expression, we determined that MRG-1 is required to maintain repression in the maternal germ line of transgenes on extrachromosomal arrays...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (4): 611–619.
Published: 15 February 2006
..., characteristic aetiology. * Author for correspondence (e-mail: richard.roy@mcgill.ca ) 1 12 2005 © 2006. 2006 Insulin TGF- β AMPK PTEN LKB1 Cell cycle Lifespan Dauer Germ line C. elegans Following embryogenesis in C. elegans , the first stage (L1...
Journal Articles
Journal Articles
Journal: Development
Development (2000) 127 (14): 3119–3129.
Published: 15 July 2000
... in these neurons, a hypothesis recently confirmed by Conradt and Horvitz (1999) . Although tra-1 is clearly the master-control gene for sex determination in the soma, its role in the germ line has been elusive. Whereas gain-of-function mutations in tra-1 cause all germ cells to differentiate as oocytes...
Journal Articles
Journal Articles