... neural stem cells (NSCs) with unique properties and growth requirements. Adult NSCs constitute a reversibly quiescent cell population that can be activated by extracellular signals from the microenvironment in which they reside in vivo . Although genomic imprinting plays a role in adult neurogenesis...

... process ( Dawlaty et al., 2013 ; Yamaguchi et al., 2013 ). Until now, the role of TET1 in genomic imprinting was poorly understood, given the paucity of data involving the female germline and lack of allele-specific expression analysis in the offspring. Here, we used a Tet1 null allele...

.... Summary: Maternal inheritance of a mutation to block RNA elongation through KvDMR1 results in an absence of DNA methylation at KvDMR1, biallelic expression of Kcnq1ot1 and suppression of maternally expressed genes. KvDMR1 Genomic imprinting Imprinting control region Kcnq1ot1 Methylation...

...Emily Swanzey; Matthias Stadtfeld Genomic imprinting results in the monoallelic expression of genes that encode important regulators of growth and proliferation. Dysregulation of imprinted genes, such as those within the Dlk1-Dio3 locus, is associated with developmental syndromes and specific...

...: Expression of H19 regulates muscle stem cell number and controls their entry into quiescence. Absence of H19 leads to better muscle regeneration with increased expression of the IGN genes. Satellite cells Quiescence Genomic imprinting Epigenetics Mouse The H19 gene produces an imprinted...

...Hitomi Matsuzaki; Eiichi Okamura; Takuya Takahashi; Aki Ushiki; Toshinobu Nakamura; Toru Nakano; Kenichiro Hata; Akiyoshi Fukamizu; Keiji Tanimoto Genomic imprinting is a major monoallelic gene expression regulatory mechanism in mammals, and depends on gamete-specific DNA methylation of specialized...

... expressed imprinted gene Rtl1 and acts via trans-homologue interactions to regulate Rtl1 dosage and placental growth. Genomic imprinting Rtl1 (Peg11) miR-127 Mir127 Placenta development Mammalian genomic imprinting is an epigenetic process whereby genes are mono-allelically expressed...

... of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Haploid cells ES cells Genetic screening Transgenics Genomic imprinting...

... faithfully recapitulates the developmental onset of Igf2r imprinted expression ( Latos et al., 2009 ). ESCs are frequently used as models for X-chromosome inactivation (XCI) ( Navarro and Avner, 2010 ) and are becoming more appreciated for genomic imprinting studies ( Kohama et al., 2012 ). An ESC study...

... ( luisa.dandolo@inserm.fr ) Competing interests statement The authors declare no competing financial interests. 1 1 2013 © 2013. Published by The Company of Biologists Ltd Diaphragm differentiation Genomic imprinting Myogenesis In mammals, several myogenic regulatory...

.... 2012 Noncoding RNA Epigenetics Chromatin Kcnq1ot1 Heterochromatin Mouse Genomic imprinting * These authors equally contributed to this work ‡ Author for correspondence ( Kanduri.Chandrasekhar@gu.se ) During the past few years, a large number of studies have focused...

...Michael C. Golding; Lauren S. Magri; Liyue Zhang; Sarah A. Lalone; Michael J. Higgins; Mellissa R. W. Mann To understand the complex regulation of genomic imprinting it is important to determine how early embryos establish imprinted gene expression across large chromosomal domains. Long non-coding...

... statement The authors declare no competing financial interests. 7 12 2010 © 2011. 2011 DNA methylation Differentially methylated region (DMR) Genomic imprinting Non-CpG methylation Oocyte Sperm Mouse Genomic imprinting is a parental origin-specific gene-marking...

... at the Prader-Willi/Angelman syndrome region . Hum. Mol. Genet. 11 , 1527 - 1538 . Charalambous M. , da Rocha S. T. , Ferguson-Smith A. C. ( 2007 ). Genomic imprinting, growth control and the allocation of nutritional resources: consequences for postnatal life . Curr. Opin...

... methylation is one of multiple levels of regulation of genomic imprinting at the Kcnq1 locus and that affecting one of these levels results in a partial relaxation of imprinting. Fig. 3. The effect of the 890-bp deletion on DNA methylation at the Kcnq1 locus. ( A-D ) Methylation analysis...

... new perspectives in the comprehension of the role of genomic imprinting in embryonic growth and in human imprinting pathologies. References Ainscough, J. F., Koide, T., Tada, M., Barton, S. and Surani, M. A. ( 1997 ). Imprinting of Igf2 and H19 from a 130 kb YAC transgene. Development...

...Paulina A. Latos; Stefan H. Stricker; Laura Steenpass; Florian M. Pauler; Ru Huang; Basak H. Senergin; Kakkad Regha; Martha V. Koerner; Katarzyna E. Warczok; Christine Unger; Denise P. Barlow Genomic imprinting is an epigenetic process that results in parental-specific gene expression. Advances...

...Shau-Ping Lin; Phil Coan; Simao Teixeira da Rocha; Herve Seitz; Jerome Cavaille; Pi-Wen Teng; Shuji Takada; Anne C. Ferguson-Smith Genomic imprinting is an epigenetic mechanism controlling parental-origin-specific gene expression. Perturbing the parental origin of the distal portion of mouse...

... Culture Genomic imprinting Karyotype Spermatogenesis Stem cell Telomere An important characteristic of stem cells is their ability to self-renew( Potten, 1992 ). Although many stem cells are believed to divide infinitely by self-renewal division, there is little evidence that demonstrates...

...Jiyoung Lee; Kimiko Inoue; Ryuichi Ono; Narumi Ogonuki; Takashi Kohda; Tomoko Kaneko-Ishino; Atsuo Ogura; Fumitoshi Ishino Genomic imprinting is an epigenetic mechanism that causes functional differences between paternal and maternal genomes, and plays an essential role in mammalian development...