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Keywords: Genome editing
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Reproductive biology
Journal: Development
Development (2023) 150 (2): dev201095.
Published: 17 January 2023
... roles for AKT1, a serine/threonine kinase, in placental development using a genome-edited/loss-of-function rat model. Disruption of AKT1 resulted in placental, fetal and postnatal growth restriction. Forkhead box O4 ( Foxo4 ), which encodes a transcription factor and known AKT substrate, was abundantly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199536.
Published: 13 October 2021
...). Crispr Maternal effect Genome editing Early development Zebrafish Kpna7 Fhdc3 Summary: A method exploiting the biallelic editing ability CRISPR-Cas9 to create maternal crispants enables the identification of maternal-effect genes in a single generation. © 2021. Published...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (19): dev193029.
Published: 12 October 2020
... effects and that tek is missing in most fish. Tek ( Tie2 ) Cardiovascular development Genome editing Morpholino Evolutionary genetics Functional diversification The cardiovascular system is one of the first organs to form and function, and its development is regulated by complex...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (22): 4097–4100.
Published: 15 November 2016
... Stem Cell Symposium this year. Bioinformatics Computational biology Epigenetics Genome editing Stem cells Transcription Quantitative approaches have been boosted across many areas of biology by the relentless improvements in sequencing, imaging, computational methods...
Journal Articles
Journal: Development
Development (2016) 143 (15): 2868–2875.
Published: 1 August 2016
...Ira L. Blitz; Margaret B. Fish; Ken W. Y. Cho CRISPR/Cas9 genome editing is revolutionizing genetic loss-of-function analysis but technical limitations remain that slow progress when creating mutant lines. First, in conventional genetic breeding schemes, mosaic founder animals carrying mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2344–2355.
Published: 1 July 2016
.... Using CRISPR/Cas9-mediated genome editing, we generated and analyzed developmental defects in mice carrying additional Golgb1 loss-of-function mutations, which supported a crucial requirement for Golgb1 in palate development. Through maxillary explant culture assays, we demonstrate that the Golgb1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (11): 2025–2037.
Published: 1 June 2016
... effective ( Gagnon et al., 2014 ; Kotani et al., 2015 ; Sung et al., 2014 ). CRISPR-Cas9 Zebrafish Mutagenesis Genome editing RNP CrispantCal CrispRVariants Summary: Maximal mutagenesis efficiency is achieved in vivo in zebrafish embryos using salt-solubilized, fluorescently...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (24): 4827–4830.
Published: 15 December 2014
...Uwe Irion; Jana Krauss; Christiane Nüsslein-Volhard The introduction of engineered site-specific DNA endonucleases has brought precise genome editing in many model organisms and human cells into the realm of possibility. In zebrafish, loss-of-function alleles have been successfully produced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4115–4120.
Published: 1 November 2014
... ( albertostolfi@gmail.com ; lc121@nyu.edu ) Competing interests The authors declare no competing financial interests. 18 6 2014 1 9 2014 © 2014. Published by The Company of Biologists Ltd 2014 Ascidians CRISPR/Cas9 Ciona Ebf Genome editing Islet Recent advances have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (17): 3331–3339.
Published: 1 September 2014
... the activation of the Shh response ( Corbit et al., 2005 ; Huangfu and Anderson, 2005 ; Rohatgi et al., 2007 ). This model explains the widespread activation of the Shh response observed in the absence of Ptch1 ( Goodrich et al., 1997 ). Patched1 Patched2 Shh Genome editing Mouse embryonic stem...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (3): 707–714.
Published: 1 February 2014
... nucleases (TALENs), which require either complex design and selection or laborious construction. Thus, easy and efficient genome editing tools are still highly desirable for this species. Here, we report that RNA-guided Cas9 nuclease resulted in precise targeted gene disruption in all ten X. tropicalis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (24): 4982–4987.
Published: 15 December 2013
...Alexander Hruscha; Peter Krawitz; Alexandra Rechenberg; Verena Heinrich; Jochen Hecht; Christian Haass; Bettina Schmid Gene modifications in animal models have been greatly facilitated through the application of targeted genome editing tools. The prokaryotic CRISPR/Cas9 type II genome editing...
Includes: Supplementary data