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Keywords: Gene-environment interactions
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Journal Articles

Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength

Jennifer H. Kong, Cullen B. Young, Ganesh V. Pusapati, F. Hernán Espinoza, Chandni B. Patel, Francis Beckert, Sebastian Ho, Bhaven B. Patel, George C. Gabriel, L. Aravind, J. Fernando Bazan, Teresa M. Gunn, Cecilia W. Lo, Rajat Rohatgi
Journal: Development
Development (2021) 148 (19): dev199867.
DOI: https://doi.org/10.1242/dev.199867
Published: 4 October 2021
... show that the penetrance of birth defects can be modulated by gene-environment interactions that alter ligand sensitivity in the Hh pathway. Mosmo (previously named Atthog ) is a previously unannotated gene we initially identified in a loss-of-function CRISPR screen conducted in NIH/3T3...
View article titled, Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength
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Includes: Supplementary data