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Keywords: Gene regulatory networks
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Journal Articles
Journal: Development
Development (2021) 148 (19): dev198614.
Published: 27 September 2021
...%) examined, and included in published developmental gene regulatory networks (dGRNs), are present in the Lv- scRNA-seq dataset and are expressed in the correct lineages in which the dGRN circuits operate. National Institutes of Health http://dx.doi.org/10.13039/100000002 RO1 HD 14483...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (14): dev196022.
Published: 19 July 2021
... neurons/IPNs that is involved in commissure and neuron projection development. We next aimed to investigate the influence of TCF4 on gene regulatory networks (GRNs) using the R package SCENIC. Identified regulons were binarized to generate a high/low activity state ( Fig. 4 A). Re-clustering...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (14): dev199497.
Published: 12 July 2021
... at large. Leading scientists from a range of disciplines, including developmental biology, physics, chemistry and computer science, covered a gamut of topics from the principles of cell and tissue organization, patterning and gene regulatory networks, to synthetic approaches for exploring evolutionary...
Journal Articles
Journal: Development
Development (2021) 148 (8): dev195859.
Published: 19 April 2021
... embryos that use endogenous hypoxia and redox gradients as morphogens during normal development. Here, we show that the tolerance to hypoxic conditions changes between different developmental stages of the sea urchin embryo, possibly due to the structure of the gene regulatory networks (GRNs). We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (20): dev193888.
Published: 26 October 2020
.... and Briscoe , J. ( 2017 ). A gene regulatory network balances neural and mesoderm specification during vertebrate trunk development . Dev. Cell   41 , 243 - 261.e7 . 10.1016/j.devcel.2017.04.002 Graveson , A. C. , Smith , M. M. and Hall , B. K. ( 1997 ). Neural crest potential...
Journal Articles
Journal: Development
Development (2019) 146 (24): dev168799.
Published: 16 December 2019
... downregulation of the anterior neuroectoderm (ANE) gene regulatory network (GRN) by canonical Wnt/β-catenin and non-canonical Wnt1/Wnt8-Fzl5/8-JNK signaling. This study focuses on the non-canonical function of the Wnt16 ligand during early AP specification and patterning. Maternally supplied wnt16 is expressed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev176727.
Published: 27 June 2019
...Urs Mayr; Denise Serra; Prisca Liberali; Allon Klein; Barbara Treutlein ABSTRACT Complex 3D tissues arise during development following tightly organized events in space and time. In particular, gene regulatory networks and local interactions between single cells lead to emergent properties...
Journal Articles
Journal: Development
Development (2017) 144 (14): 2548–2559.
Published: 15 July 2017
... in the context of development as a hierarchical and canalized series of gene regulatory networks. In this scheme, only a fraction of embryonic miRNAs act at the top of this hierarchy, with their loss resulting in broad developmental defects, whereas most other miRNAs are expressed with high cellular specificity...
Journal Articles
Journal: Development
Development (2017) 144 (1): 17–32.
Published: 01 January 2017
Journal Articles
Journal: Development
Development (2016) 143 (15): 2696–2705.
Published: 01 August 2016
... and activating hierarchical gene regulatory networks responsible for embryonic patterning. Understanding these developmental contexts will be essential for the precise engineering of cell identity. Moving forward, it will be essential to address the reprogramming roles of additional regulators of cell fate...
Journal Articles
Journal: Development
Development (2016) 143 (9): 1523–1533.
Published: 01 May 2016
...., 2012 ; Range, 2014 ). Based on the spatial and temporal expression of ANE regulatory genes in several species, it appears that the ANE gene regulatory network (GRN) hierarchy is also remarkably conserved among many deuterostome embryos, suggesting that these could be homologous territories ( Range...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (12): 2121–2135.
Published: 15 June 2015
... has cell type-specific targets and functions: it acts with SMAD1 to promote mesoderm specification, while in the endoderm it interacts with SMAD2/3. SMAD T-BOX Embryonic stem cells Gastrulation Gene regulatory networks Human The three primary germ layers (ectoderm, mesoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (9): 1927–1939.
Published: 01 May 2014
..., and that genes activated in the second wave of expression, including Brachyury and Mixer , contribute to the regulation of genes expressed in the third. Together, our high-resolution time series and experimental studies have yielded a deeper understanding of the temporal organisation of gene regulatory networks...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (15): 3297–3306.
Published: 01 August 2011
...Jenifer Croce; Ryan Range; Shu-Yu Wu; Esther Miranda; Guy Lhomond; Jeff Chieh-fu Peng; Thierry Lepage; David R. McClay In the sea urchin, entry of β-catenin into the nuclei of the vegetal cells at 4th and 5th cleavages is necessary for activation of the endomesoderm gene regulatory network. Beyond...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (12): 2581–2590.
Published: 15 June 2011
...Tara Sharma; Charles A. Ettensohn The well-known regulative properties of the sea urchin embryo, coupled with the recent elucidation of gene regulatory networks (GRNs) that underlie cell specification, make this a valuable experimental model for analyzing developmental plasticity. In the sea urchin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (17): 3077–3087.
Published: 01 September 2007
... has focused on transcriptional gene regulatory networks (GRNs) deployed in specific embryonic territories during early development. The micromere-primary mesenchyme cell(PMC) GRN drives the development of the embryonic skeleton. Although normally deployed only by presumptive PMCs, every lineage...