.../10.13039/100000057 Rutgers, The State University of New Jersey http://dx.doi.org/10.13039/100011132 Developmental genes Anterior-posterior axis coordination Genes tagging Gene regulatory network Shared enhancers Cis -regulation Summary: CRISPR/Cas9 genome editing reveals...

... of nephron progenitors through shared gene regulatory networks . Dev. Cell 23 , 637 - 651 . 10.1016/j.devcel.2012.07.008 Peterson , R. S. , Lim , L. , Ye , H. , Zhou , H. , Overdier , D. G. and Costa , R. H. ( 1997 ). The winged helix transcriptional activator HFH-8...

...Chee Kiang Ewe; Erica M. Sommermann; Josh Kenchel; Sagen E. Flowers; Morris F. Maduro; Pradeep M. Joshi; Joel H. Rothman ABSTRACT The architecture of gene regulatory networks determines the specificity and fidelity of developmental outcomes. We report that the core regulatory circuitry for endoderm...

...Shannon E. Taylor; Peter K. Dearden ABSTRACT Insect segmentation is a well-studied and tractable system with which to investigate the genetic regulation of development. Though insects segment their germband using a variety of methods, modelling work implies that a single gene regulatory network can...

...Megan K. Rommelfanger; Adam L. MacLean ABSTRACT Cells do not make fate decisions independently. Arguably, every cell-fate decision occurs in response to environmental signals. In many cases, cell-cell communication alters the dynamics of the internal gene regulatory network of a cell to initiate...

... to the dysfunction, and sometimes the death, of these photoreceptors ( Campochiaro and Mir, 2018 ; https://sph.uth.edu/retnet/ ). As cones are the type of photoreceptor that we use to initiate color and daylight vision, their loss can be devastating. A better understanding of the gene regulatory networks (GRNs...

...Katherine Exelby; Edgar Herrera-Delgado; Lorena Garcia Perez; Ruben Perez-Carrasco; Andreas Sagner; Vicki Metzis; Peter Sollich; James Briscoe ABSTRACT During development, gene regulatory networks allocate cell fates by partitioning tissues into spatially organised domains of gene expression. How...

... the dorsal-ventral axis specification in sea urchin embryos, highlighting key features of Nodal and BMP antagonism. Paracentrotus lividus Embryo development Logical model Gene regulatory network Nodal pathway BMP pathway During embryonic development, cell fate is specified...

... is under robust, complex control. We found that one candidate regulator, the G-class bZIP transcription factor GBF2, can modulate vascular gene expression by tuning MP output through direct interaction. Our work uncovers components of a gene regulatory network that controls the initial specification...

... variant upstream of the core gene regulatory network in the neural crest lineage. This epigenetic mark is a key determinant of cell fate and facilitates gene activation by external instructive signals, thereby establishing melanocyte fate identity. Across vertebrates, the histone variant H2A.Z...

... in the developing mouse retina. Enhancer Transcription factor Non-coding RNA (ncRNA) Photoreceptor Nrl Crx Rod Cone Gene regulatory network Cis -regulatory element Identification of tissue- and context-specific cis -regulatory elements (CREs) is essential for the definition...

...Taylor N. Medwig-Kinney; Jayson J. Smith; Nicholas J. Palmisano; Sujata Tank; Wan Zhang; David Q. Matus ABSTRACT Cellular invasion is a key part of development, immunity and disease. Using an in vivo model of Caenorhabditis elegans anchor cell invasion, we characterize the gene regulatory network...

... in discrete domains along the dorsal-ventral and anterior-posterior axes of the embryonic spinal cord. This organization arises in response to morphogen gradients acting upstream of a gene regulatory network, the architecture of which determines the spatial and temporal pattern of gene expression. In recent...

... regulatory network that controls skeletogenesis in sea urchins and other echinoderms. Alx1 transcription factor ChIP-seq Gene regulatory network Sea urchin skeletogenesis Biomineralization Primary mesenchyme cells (PMCs) A central challenge of biology is to explain how morphology...

... understanding of the regulatory pathway is essential for accurate modeling in order to deduce principles for gene regulatory network dynamics, and for comparative analysis on how ascidians have evolved the cell-autonomous gene regulatory mechanism. Here, we reveal regulatory interactions among three key...

...-repressor Groucho by the transcriptional activator Pointed confers precision and robustness to the gene expression dynamics that drive developmental cell fate transitions. Gene regulatory network Cell fate specification Chromatin occupancy Mesoderm development RNA pol II pausing Genetic...

.... Highlighted Article: Caudal, Dichaete and Odd-paired are likely to regulate pair-rule gene expression similarly in Drosophila and Tribolium , providing a simple mechanism for the evolutionary transition between short-germ and long-germ segmentation modes. Drosophila Gene regulatory network Pair...

... of the STM gene regulatory network (GRN) are largely unknown. Here, we show that transcriptional regulators are overrepresented among STM-regulated genes and, using these as GRN components in Bayesian network analysis, we infer STM GRN associations and reveal regulatory relationships between STM and factors...

... hair growth by directly repressing RSL4 . Root hair Cell growth Trihelix transcription factor Gene regulatory network Plant cells often undergo extensive post-mitotic cell expansion and can reach up to several hundred-fold their original size ( Sugimoto-Shirasu and Roberts, 2003...

... of developmental processes such as molecular patterning and tissue morphogenesis, highlighting their advantages and limitations, and their crucial role in future research. Computer modeling Simulation Developmental biology Morphogenesis Gene regulatory network Gene circuit D'Arcy Thompson's...