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Keywords: Gene regulation
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Journal Articles
Journal: Development
Development (2022) 149 (3): dev200250.
Published: 11 February 2022
... ( Buchsbaum and Cappello, 2019 ). Queen's University Belfast http://dx.doi.org/10.13039/501100000873 Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 TI 799/1-3 Cortical development Neurogenesis Epigenetics Genomics Gene regulation Transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199744.
Published: 7 September 2021
... and detection optics, localization and tracking algorithms, and data analysis. Finally, we provide a summary of selected recent applications of SMT to study the dynamics of gene regulation. References Abbe , E. ( 1873 ). Beitrage zur theorie des mikroskops und der mikroskopischen Wahrnehmung...
Journal Articles
Journal: Development
Development (2021) 148 (9): dev182667.
Published: 29 April 2021
...Ersin Akinci; Marisa C. Hamilton; Benyapa Khowpinitchai; Richard I. Sherwood ABSTRACT Understanding how genes are expressed in the correct cell types and at the correct level is a key goal of developmental biology research. Gene regulation has traditionally been approached largely through...
Journal Articles
Journal: Development
Development (2020) 147 (21): dev194233.
Published: 21 October 2020
... into the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased heart...
Journal Articles
Journal: Development
Development (2020) 147 (19): dev161430.
Published: 5 October 2020
... of these enhancers as environments with the correct combination of factors and co-factors would be required. Transcription dependent on low-affinity interactions would also stop quickly as soon as the local concentration of factors is no longer present, enabling high temporal precision in gene regulation...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev175059.
Published: 19 June 2020
... development and evolution. Lateral plate mesoderm Cardiovascular system Cell fate Development Evolution Gene regulation During gastrulation in vertebrates, the mesoderm forms axial, paraxial and lateral domains that harbor precursor cells for distinct organ systems. The lateral plate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev175141.
Published: 11 June 2020
... inactivation: a crossroads between chromosome architecture and gene regulation . Annu. Rev. Genet.   52 , 535 - 566 . 10.1146/annurev-genet-120116-024611 Gobert , V. , Osman , D. , Bras , S. , Augé , B. , Boube , M. , Bourbon , H.-M. , Horn , T. , Boutros , M...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (6): dev181909.
Published: 16 March 2020
... in the same cells to respond to spatial cues through regulation of chromatin accessibility. Temporal transcription factor Chromatin accessibility Enhancer Gene regulation Ecdysone Drosophila Cis -regulatory regions such as enhancers and promoters interpret multiple types of inputs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev171736.
Published: 3 February 2020
... and the techniques that can be used to study them. Regulatory landscape Gene regulation Topologically associating domains Enhancer-promoter interactions Pleiotropy Neo-functionalization Animal development provides an excellent system in which to study the mechanisms of gene transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev185314.
Published: 9 December 2019
...Matthew R. George; Qiming Duan; Abigail Nagle; Irfan S. Kathiriya; Yu Huang; Kavitha Rao; Saptarsi M. Haldar; Benoit G. Bruneau ABSTRACT Long intergenic non-coding RNAs (lincRNAs) have been implicated in gene regulation, but their requirement for development needs empirical interrogation. We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev177162.
Published: 26 September 2019
...Elizabeth Ing-Simmons; Juan M. Vaquerizas ABSTRACT The three-dimensional organisation of the genome plays a crucial role in developmental gene regulation. In recent years, techniques to investigate this organisation have become more accessible to labs worldwide due to improvements in protocols...
Journal Articles
Journal: Development
Development (2019) 146 (19): dev182766.
Published: 25 September 2019
...Mustafa Mir; Wendy Bickmore; Eileen E. M. Furlong; Geeta Narlikar ABSTRACT In the past decade, two major advances in our understanding of nuclear organization have taken the field of gene regulation by storm. First, technologies that can analyze the three-dimensional conformation of chromatin have...
Journal Articles
Journal: Development
Development (2019) 146 (19): dev181180.
Published: 20 September 2019
... that H3K9me3 deposition requires protein SUMOylation in different contexts, suggesting that the SUMO pathway functions as an important module in gene silencing and heterochromatin formation. In this Review, we discuss the role of H3K9me3 in gene regulation in various systems and the molecular mechanisms...
Journal Articles
Journal: Development
Development (2019) 146 (18): dev181339.
Published: 19 September 2019
...: An integrated genomic approach identifies Shh-responsive genes and associated regulatory sequences with known and previously uncharacterized roles in cochlear morphogenesis, including genes that prime the cochlea for sensory development. Cochlea Organ of Corti Otic vesicle Sensory development Gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev174086.
Published: 5 July 2019
... in beating, including number of beats per minute and amplitude of beating (peak heights) ( Fig. 3 D), which are indicative of abnormal cardiac differentiation. Directed differentiation phenotypes must, of course, be interpreted with caution, as a defective gene regulation program may be overcome by a strong...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev170217.
Published: 27 June 2019
...Connor H. Ludwig; Lacramioara Bintu; Allon Klein; Barbara Treutlein ABSTRACT Understanding chromatin regulation holds enormous promise for controlling gene regulation, predicting cellular identity, and developing diagnostics and cellular therapies. However, the dynamic nature of chromatin, together...
Journal Articles
Journal: Development
Development (2019) 146 (11): dev176107.
Published: 12 June 2019
...://www.biologists.com/user-licence-1-1/ Highlighted Article: Reciprocal interactions between BMP-response elements and the cis -regulatory environment control Dpp-dependent transcriptional gene activation in developing Drosophila epithelia. Gene regulation Tissue patterning TGFβ signaling wit...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev173666.
Published: 15 March 2019
... of gene regulation in vivo . Several DamID-based methods could be combined to allow an even broader range of biological problems to be approached. For example, an MS2-tagged lncRNA could be co-expressed with a transcription factor using the split DamID technique to assay co-occupancy of a transcript...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2018) 145 (13): dev164855.
Published: 4 July 2018
... of postmeiotic genes in mouse testes. Sox30 Male germ cell Spermiogenesis Gene regulation Mouse The developmental progression of round spermatids into mature spermatozoa, termed spermiogenesis, requires multiple molecular events, including profound nuclear restructuring and condensation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3646–3658.
Published: 15 October 2017
... and Cavalli, 2016 ). Characterization of the various components that control gene regulation, i.e. enhancers, promoters and their associated 3D interactions, has become a standard approach to deciphering the mechanisms underlying transcriptional control and has thus provided new frameworks...