... attributed. Highlighted Article: Using transgenic mice that overexpress Sall1 in ovaries, we demonstrate the capacity of this factor to activate kidney-related gene programs that are also observed during mole ovotestis formation. Evolutionary genomics Gene regulation Gonad development...

...Aurélie Hintermann; Isabel Guerreiro; Lucille Lopez-Delisle; Christopher Chase Bolt; Sandra Gitto; Denis Duboule; Leonardo Beccari ABSTRACT Modifications in gene regulation are driving forces in the evolution of organisms. Part of these changes involve cis- regulatory elements (CREs), which contact...

... Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 TI 799/1-3 Cortical development Neurogenesis Epigenetics Genomics Gene regulation Transcription factors Summary: How the functional cooperativity of Tcf12 and NeuroD1 in specific subpopulations of the developing cortex creates...

... and detection optics, localization and tracking algorithms, and data analysis. Finally, we provide a summary of selected recent applications of SMT to study the dynamics of gene regulation. * These authors contributed equally to this Review; their order was determined by a coin toss ‡ Author...

...Ersin Akinci; Marisa C. Hamilton; Benyapa Khowpinitchai; Richard I. Sherwood ABSTRACT Understanding how genes are expressed in the correct cell types and at the correct level is a key goal of developmental biology research. Gene regulation has traditionally been approached largely through...

... into the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased heart...

... in the context of embryogenesis, covering their formation, physical properties, functions in gene regulation and how they could facilitate the evolution of regulatory elements. Gene regulation Development Nucleus Transcription factors Transcriptional microenvironment In 1968, the geneticist...

... development and evolution. Lateral plate mesoderm Cardiovascular system Cell fate Development Evolution Gene regulation During gastrulation in vertebrates, the mesoderm forms axial, paraxial and lateral domains that harbor precursor cells for distinct organ systems. The lateral plate...

... ). Biochemical fractionation showed that Cdk8 is localized to the nucleus in ESCs and can be detected in the chromatin-associated fraction ( Fig. 1 H), which is consistent with its function in gene regulation. Fig. 1. Loss of Cdk8 impairs X-linked gene silencing by Xist . (A) Schematic of the Xist...

... in the same cells to respond to spatial cues through regulation of chromatin accessibility. Temporal transcription factor Chromatin accessibility Enhancer Gene regulation Ecdysone Drosophila Cis -regulatory regions such as enhancers and promoters interpret multiple types of inputs...

... and the techniques that can be used to study them. Regulatory landscape Gene regulation Topologically associating domains Enhancer-promoter interactions Pleiotropy Neo-functionalization Animal development provides an excellent system in which to study the mechanisms of gene transcription...

...Matthew R. George; Qiming Duan; Abigail Nagle; Irfan S. Kathiriya; Yu Huang; Kavitha Rao; Saptarsi M. Haldar; Benoit G. Bruneau ABSTRACT Long intergenic non-coding RNAs (lincRNAs) have been implicated in gene regulation, but their requirement for development needs empirical interrogation. We...

...Elizabeth Ing-Simmons; Juan M. Vaquerizas ABSTRACT The three-dimensional organisation of the genome plays a crucial role in developmental gene regulation. In recent years, techniques to investigate this organisation have become more accessible to labs worldwide due to improvements in protocols...

...Mustafa Mir; Wendy Bickmore; Eileen E. M. Furlong; Geeta Narlikar ABSTRACT In the past decade, two major advances in our understanding of nuclear organization have taken the field of gene regulation by storm. First, technologies that can analyze the three-dimensional conformation of chromatin have...

... that H3K9me3 deposition requires protein SUMOylation in different contexts, suggesting that the SUMO pathway functions as an important module in gene silencing and heterochromatin formation. In this Review, we discuss the role of H3K9me3 in gene regulation in various systems and the molecular mechanisms...

... the cochlea for sensory development. Cochlea Organ of Corti Otic vesicle Sensory development Gene regulation Shh signaling Mouse The organ of Corti is a specialized sensory structure for hearing in mammals that lines the length of the cochlear duct. It comprises a single row of inner hair...

... that are important for BAF complex composition and for regulating cardiac gene expression. Heart Differentiation Chromatin Gene regulation Cell differentiation and organogenesis are regulated by the precise transcriptional output of a coordinated gene regulatory network ( Davidson, 2010 ). During...

...Connor H. Ludwig; Lacramioara Bintu; Allon Klein; Barbara Treutlein ABSTRACT Understanding chromatin regulation holds enormous promise for controlling gene regulation, predicting cellular identity, and developing diagnostics and cellular therapies. However, the dynamic nature of chromatin, together...

...://www.biologists.com/user-licence-1-1/ Highlighted Article: Reciprocal interactions between BMP-response elements and the cis -regulatory environment control Dpp-dependent transcriptional gene activation in developing Drosophila epithelia. Gene regulation Tissue patterning TGFβ signaling wit...