1-11 of 11
Keywords: Gene dosage
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal: Development
Development (2023) 150 (22): dev202072.
Published: 23 November 2023
... female development or fertility. Elsie Jacobson (University of California, Los Angeles, USA) used a mouse Xist mutant with defective X-inactivation to investigate the impact of increased X-linked gene dosage on placental development, with implications for mammalian evolution and human disease (Kathrin...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (23): 4462–4473.
Published: 1 December 2016
.... Gene dosage has been associated with variations in disease severity. For example, Pax6 deletion results in the absence of eyes; however, Pax6 haploinsufficiency leads to defects in the anterior segment of the eye that results in small eye in mice and aniridia in humans ( Davis et al., 2009...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2011) 138 (3): 443–454.
Published: 1 February 2011
.... Multipotential retinal progenitors Ciliary epithelium SOX2 PAX6 Gene dosage Mouse The vertebrate eye, which is composed of neurogenic and non-neurogenic structures, arises from a single progenitor pool in the optic vesicle. The eye, therefore, provides a useful and accessible model...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (9): 1453–1464.
Published: 1 May 2009
... in Gdf11 rescue, to a considerable degree, the major defects in Foxg1 -/- OE,including the early, severe loss of neural precursors and olfactory receptor neurons, and the subsequent collapse of both neurogenesis and nasal cavity formation. Rescue is gene-dosage dependent, with loss of even one allele...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (15): 2761–2769.
Published: 1 August 2007
... neurons during early and late differentiation of midbrain dopaminergic neurons. Interestingly, genetic evidence indicates that these functions require different gene dosages of Foxa1 and Foxa2 . Altogether, our results demonstrate that Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (12): 2349–2358.
Published: 15 June 2007
.... * Author for correspondence (e-mail: amanda.swain@icr.ac.uk ) 4 4 2007 © 2007. 2007 Adrenal development Gene dosage Organogenesis Mouse The adrenal cortex and gonad are the main steroid-producing tissues in mammals. Although they produce different steroid hormones...
Journal Articles
Journal: Development
Development (2004) 131 (10): 2349–2358.
Published: 15 May 2004
... oligodendrocytes arguing that this process is as sensitive to Sox10 gene dosage as the development of melanocytes and the enteric nervous system ( Britsch et al., 2001 ; Herbarth et al.,1998a ; Pingault et al.,1998 ; Southard-Smith et al.,1998 ). The delay of terminal oligodendrocyte differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (6): 1149–1158.
Published: 15 March 2003
... from the rest of the plant,these mutants could make the meristem less sensitive to the signal needed for meristem conversion (this is equivalent to raising the signaling threshold). Fig. 9. Gene dosage model for SM and SPM identity. SPMs are wild type (green) with even one dose of ids1...
Journal Articles
Journal: Development
Development (2002) 129 (2): 329–337.
Published: 15 January 2002
... for correspondence (e-mail: scamper@umich.edu ) 23 10 2001 © 2002. 2002 Pitx2 Pitx1 Gata2 Allelic series Gene dosage Cell specification Mouse The mammalian Pitx gene family consists of three bicoid-related homeobox genes, each with an important role in the development...
Journal Articles
Journal: Development
Development (1995) 121 (12): 3997–4003.
Published: 1 December 1995
...-type embryos fail to elicit malformations in RXR α homozygotes, implicating RXRα as a component in the teratogenic process in the limbs. Heterozygous embryos are intermediate in sensitivity to RA, suggesting the importance of RXRα gene dosage in limb teratogenesis. Expression of the RA-inducible gene...