... is necessary for gastrula organizer gene induction and posterior axis development. Wnt3 expression and Wnt/β-catenin activity are restricted to the posterior epiblast and PVE at E5.5-6.5 ( Ferrer-Vaquer et al., 2010 ; Rivera-Pérez and Magnuson, 2005 ) and initiate A-P asymmetries and posterior mesendoderm...

..., branchial arches and pectoral fins. Our studies reveal essential roles for prdm1 in limiting the function of the gastrula organizer and regulating cell fate specification and morphogenetic processes in precise correspondence with its intricate expression pattern. Fig. 7. Early loss-of-function...

...TinChung Leung; Johannes Bischof; Iris Söll; Dierk Niessing; Dongyi Zhang; Jun Ma; Herbert Jäckle; Wolfgang Driever Formation of the gastrula organizer requires suppression of ventralizing signals and, in fish and frog, the need to counteract the effect of ubiquitously present maternal factors...

... , and the ability of these cells to induce a second neural axis in the host embryo. This cell population can therefore be regarded as the mid-gastrula organizer and, together with the early-gastrula organizer and the node, constitute the organizer of the mouse embryo at successive stages of development. The profile...

... fragment that contains the early gastrula organizer was able to recruit the host tissues to form an ectopic axis. However, the most anterior neural gene that was expressed in the ectopic axis was Krox20 that marks parts of the hindbrain, but markers of the mid-and forebrain ( Otx2 and En1 ) were...