...Alexis Garretson; Beth L. Dumont; Mary Ann Handel ABSTRACT Genetic analyses of mammalian gametogenesis and fertility have the potential to inform about two important and interrelated clinical areas: infertility and contraception. Here, we address the genetics and genomics underlying gamete...

... of coding and non-coding RNAs needed for gametogenesis. References Akhtar, A. and Gasser, S. M. ( 2007 ). The nuclear envelope and transcriptional control. Nat. Rev. Genet. 8 , 507 -517. Aravin, A., Gaidatzis, D., Pfeffer, S., Lagos-Quintana, M.,Landgraf, P., Iovino, N., Morris, P., Brownstein...

... are functionally redundant. Genetic crosses were employed to examine the consequences of reduced SMC2 levels. Both male and female gametogenesis were compromised in double mutant spores. Embryo lethality was observed for both double homozygous and AtCAP-E1 -/- , AtCAP-E2 +/- plants;arrest occurred at or before...

... ( Guichard et al., 2000 ), expression of secreted forms of spi or grk in male germ cells did not rescue the stet mutant phenotype in our study. Loss-of-function alleles of grk that cause severe defects in female gametogenesis did not show an early germ cell over-proliferation phenotype in testes (C...

... of hermaphrodites briefly adopting a male mode of gametogenesis. However, our data indicating that a single chromosome pair lacking detectable activating histone modifications is present in the germlines of obligate female nematodes suggests that such is not the case ( Fig. 10 ). Another possibility is that because...

...Carmen Mertineit; Jeffrey A. Yoder; Teruko Taketo; Dale W. Laird; Jacquetta M. Trasler; Timothy H. Bestor ABSTRACT The spermatozoon and oocyte genomes bear sex-specific methylation patterns that are established during gametogenesis and are required for the allele-specific expression of imprinted...

... and the SI locus cause deficiencies in gametogenesis, melanogenesis and hematopoiesis. The c-kit receptor is expressed in the cellular targets of IF and SI mutations, while KL is expressed in their microenvironment. In melanogenesis, c-kit is expressed in melanoblasts from the time they leave the neural...