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Keywords: GSK3β
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Journal Articles
Journal: Development
Development (2022) 149 (22): dev200844.
Published: 16 November 2022
...Najat Dzaki; Shufeng Bu; Samuel Song Yuan Lau; Wei Lin Yong; Fengwei Yu ABSTRACT The evolutionarily conserved Glycogen Synthase Kinase 3β (GSK3β), a negative regulator of microtubules, is crucial for neuronal polarization, growth and migration during animal development. However, it remains unknown...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199866.
Published: 23 December 2021
... motor functions under physiological conditions. Because, within an whole organism, kinase cascades display considerable crosstalk and play multiple roles in cell homeostasis, deciphering which kinase(s) is/are involved in a particular process has been challenging. Previously, we found that GSK3β plays...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev184341.
Published: 19 January 2021
.... Depletion of DDX3 decreases AKT activity and AKT-dependent inhibitory phosphorylation of GSK3β, leading to reduced levels of β-catenin and Snai1: two GSK3β substrates that are crucial for NC induction. DDX3 function in regulating these downstream signaling events during NC induction is likely mediated...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (3): dev180232.
Published: 3 February 2020
... both neuronal polarity and axon growth. Using compartmentalised microfluidic neuronal cultures, we identified a local role for miR-26a in the axon, where the repression of local synthesis of GSK3β controls axon development and growth. Removal of this repression in the axon triggers local translation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev161042.
Published: 14 May 2018
... maintains an abbreviated cell cycle structure to permit the efficient proliferation of GSCs necessary for continuous tissue output. GSK3β Cell cycle Germ cells Stem cell proliferation Stem cells sustain tissue development and growth, and maintain tissue homeostasis by balancing the rates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (24): 4959–4969.
Published: 15 December 2013
... surface ectoderm and subsequently in dorsal optic vesicle cells. Activation of Wnt signalling by implanting Wnt3a-soaked beads or inhibiting GSK3β at optic vesicle stages inhibits NR development and converts the entire optic vesicle into RPE. Surface ectoderm removal at early optic vesicle stages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (17): 2987–2996.
Published: 1 September 2009
... levels of HA are required to sustain proliferation of mesenchymal cells in the regenerative bud. Pharmacological and genetic inhibition of GSK3βwas sufficient to rescue proliferation and tail regeneration when HA synthesis was blocked, suggesting that GSK3β is downstream of the HA pathway. We have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (18): 3137–3148.
Published: 15 September 2008
... in zebrafish by the E(Spl) factors Her5 and Her11, but the molecular cascades cooperating with Her5/11, and those accounting for their reduced effect in the medial IZ, remain unknown. We demonstrate here that the kinases Gsk3β and cAMP-dependent protein kinase A (PKA) are novel determinants of IZ formation...
Journal Articles
Journal: Development
Development (2007) 134 (12): 2207–2217.
Published: 15 June 2007
... College of Medicine,1102 Bates Street, Houston, TX 77030, USA 30 3 2007 © 2007. 2007 Endoderm Patterning Liver Pancreas Foregut Wnt β-catenin Wnt-antagonists Gsk3β Xenopus hhex foxa2 vent2 The liver and pancreas are derived from the foregut endoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (12): 2947–2956.
Published: 15 June 2004
... endomesoderm specification. Here, we use in-vivo measurements of the half-life of fluorescently tagged β-catenin in specific blastomeres to demonstrate a gradient in β-catenin stability along the animal-vegetal axis during early cleavage. This gradient is dependent on GSK3β-mediated phosphorylation of β...
Journal Articles
Journal: Development
Development (2001) 128 (20): 3877–3888.
Published: 15 October 2001
...Sandra van de Water; Marc van de Wetering; Jos Joore; John Esseling; Robert Bink; Hans Clevers; Danica Zivkovic masterblind ( mbl ) is a zebrafish mutation characterised by the absence or reduction in size of the telencephalon, optic vesicles and olfactory placodes. We show that inhibition of Gsk3β...
Journal Articles
Journal: Development
Development (2001) 128 (11): 2063–2073.
Published: 1 June 2001
... with lithium, even at the very early stages of development, results in the expansion of expression of the ventrolateral marker Xpo into the dorsal midline (T-X). Fig. 2. Lithium-mediated inhibition of GSK3β in late blastula shows involvement in ventrolateral-promoting Wnt signalling. Xenopus...