... that the heterotrimeric G protein Go functions as a transducer of Wingless-Frizzled 2 signaling in the synapse. We identify Ankyrin 2 as a target of Go signaling required for NMJ formation. Moreover, the Go-ankyrin interaction is conserved in the mammalian neurite outgrowth pathway. Without ankyrins, a major switch...

... ) 16 8 2005 ©2005. 2005 C. elegans embryos Spindle positioning G protein Asymmetric divisions play a crucial role in the generation of cell diversity. During development in particular, asymmetric divisions often give rise to daughter cells that differ not only in fates...

... time involvement of heterotrimeric G proteins in establishment of embryonic LR asymmetry and suggest how they might act. * Author for correspondence (e-mail: wood@colorado.edu ) 29 8 2003 © 2003. 2003 C. elegans Asymmetry G protein Although most animals...

... demonstrated that heterotrimeric G-protein signaling can promote EGFR and MAP kinase activation(reviewed by Gschwind et al.,2001 ; Lowes et al.,2002 ). In some instances, G-proteins promote metalloprotease-dependent shedding of the EGFR ligand, HBEGF, whereas in other cases G-proteins promote MAP kinase...

... a G-protein-coupled receptor signalling pathway and the RAS/MAPK cascade. SRA-13, a member of the SRA family of chemosensory receptors, negatively regulates RAS/MAPK signalling during vulval induction and the olfaction of volatile attractants. Epistasis analysis indicates that SRA-13 inhibits the RAS...

... to GVBD in nemertean oocytes that had been pre-injected with a cAMP fluorosensor. Such a rise in cAMP seemed to involve G-protein-mediated signaling and protein kinase A (PKA) stimulation, based on the inhibition of 5-HT-induced GVBD by specific antagonists of these transduction steps. Although...

...Chunlai Wu; Qingyi Zeng; Kendall J. Blumer; Anthony J. Muslin ABSTRACT RGS family members are GTPase activating proteins (GAPs) that antagonize signaling by heterotrimeric G proteins. Injection of Xenopus embryos with RNA encoding rat RGS4 (rRGS4), a GAP for Gi and Gq, resulted in shortened trunks...

.... and Firtel , R. A. ( 1992 ). Molecular genetic analysis of signal transduction pathways controlling multicellular development in Dictyostelium . Cold Spring Harbor Symp. Quant. Biol . 57 , 177 – 192 . 10.1101/SQB.1992.057.01.023 Devreotes , P. N. ( 1994 ). G protein-linked signaling...

...A.M. Horgan; M. T. Lagrange; P. F. Copenhaver ABSTRACT Directed neuronal migration contributes to the formation of many developing systems, but the molecular mechanisms that control the migratory process are still poorly understood. We have examined the role of heterotrimeric G proteins (guanyl...

...Arie P. Otte; L. Lynn Mcgrew; Juan Olate; Neil M. Nathanson; Randall T. Moon ABSTRACT During early embryonic development, many inductive interactions between tissues depend on signal transduction processes. We began to test the possibility that G-proteins participate in the signal transduction...

...William J. Wolfgang; Franklin Quan; Nina Thambi; Michael Forte ABSTRACT Of the known signal transduction mechanisms, the most evolutionarily ancient is mediated by a family of heterotrimeric guanine nucleotide binding proteins or G proteins. In simple organisms, this form of sensory transduction...