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Ronit S. Kaufman, Kari L. Price, Katelynn M. Mannix, Kathleen M. Ayers, Andrew M. Hudson, Lynn Cooley
Development (2020) 147 (22): dev190140.
Published: 15 November 2020
... cytokinesis during cell division. Developing germ cells in Drosophila have an additional specialized organelle connecting the cells called the fusome. Ring canals and the fusome are required for fertility in Drosophila females, but little is known about their roles during spermatogenesis. With live imaging...
Includes: Supplementary data
Development (2007) 134 (19): 3413–3418.
Published: 1 October 2007
... and stereotypic cell division, whereby only one daughter remains attached to the niche. GSCs are attached to cap cells via adherens junctions, which also appear to orient GSC division through capture of the fusome, a germline-specific organizer of mitotic spindles. Here we show that the Rab11 GTPase is required...
Development (2007) 134 (4): 703–712.
Published: 15 February 2007
... a specialized organelle called a fusome, whereas later post-mitotic cells differentiate and lose the fusome as F-actin-rich ring canals form. The hts gene encodes the only Drosophila Adducin, and is a female-sterile mutant that affects both the fusome and ring canals. We show that one Hts protein, Ovhts...
Includes: Supplementary data
Development (2006) 133 (17): 3371–3377.
Published: 1 September 2006
.... * Author for correspondence (e-mail: firstname.lastname@example.org ) 3 7 2006 © 2006. 2006 Mitochondria Oogenesis Fusome Balbiani body Microtubule Kinesin Dynein Mitochondria and other cytoplasmic organelles within the newly fertilized egg are provided exclusively by the oocyte...
Includes: Multimedia, Supplementary data
Development (2003) 130 (8): 1579–1590.
Published: 15 April 2003
... mitochondria during Drosophila oogenesis. Mitochondria partition equally on the spindle during germline stem cell and cystocyte divisions. Subsequently, a fraction of cyst mitochondria and Golgi vesicles associates with the fusome, moves through the ring canals,and enters the oocyte in a large mass...
Development (2003) 130 (5): 901–915.
Published: 1 March 2003
... and fusome, suggesting it participates in interactions between these structures. In orbit mutants, the stem cells and their associated fusomes are eventually lost as Orbit/Mast protein is depleted. The mitotic spindles of those cystocytes that do divide are either diminutive or monopolar, and do not make...
Jorge Bolívar, ean-René Huynh, Hernán López-Schier, Cayetano González, Daniel St Johnston, Acaimo González-Reyes
Development (2001) 128 (10): 1889–1897.
Published: 15 May 2001
... of all other oocyte markers and the polarisation of the microtubule cytoskeleton. In contrast, the centrosomes fail to migrate in cysts mutant for Dynein heavy chain 64C , which disrupts the fusome. Thus, centrosome migration is independent of the organisation of the microtubule cytoskeleton, and seems...
Development (2001) 128 (7): 1201–1209.
Published: 1 April 2001
... also fail to move from the anterior to the posterior of the oocyte in mutant clones. Thus, PAR-1 is required for the maintenance of oocyte identity, and plays a role in microtubule-dependent localisation within the oocyte at two stages of oogenesis. Finally, we show that PAR-1 localises on the fusome...
Development (2000) 127 (19): 4253–4264.
Published: 1 October 2000
... how the microtubule network polarizes using a GFP-tubulin construct that allows germ-cell microtubules to be visualized with greater sensitivity than in previous studies. Unexpectedly, microtubules are seen to associate with the fusome, an asymmetric germline-specific organelle, which elaborates...
Development (1999) 126 (20): 4477–4488.
Published: 15 October 1999
... ) and show that Lis1 is essential for fly development. Analysis of ovarian Lis1 mutant clones demonstrates that Lis1 is required in the germline for synchronized germline cell division, fusome integrity and oocyte differentiation. Abnormal packaging of the cysts was observed in Lis1 mutant clones. Our...
Development (1998) 125 (15): 2781–2789.
Published: 1 August 1998
... formation is not clear. We have analyzed how polarity develops in stem cells and dividing cysts by following the growth of the fusome, a vesiculated cytoplasmic organelle. Our studies show that the fusome grows by a regular, polarized process throughout the stem cell and cyst cell cycles. Each polarization...
Development (1995) 121 (9): 2937–2947.
Published: 1 September 1995
...) from the mother stem cells, perhaps by altering the cell cycle. In this paper, we report the preparation of antibodies to the Bam protein and the use of those reagents to investigate how Bam is required for germ cell development. We find that Bam exists as both a fusome component and as cytoplasmic...
Development (1994) 120 (4): 947–956.
Published: 1 April 1994
... as the fusome that has been postulated to help form ring canals and determine the pattern of nurse cell-oocyte interconnections. We identified the adducin-like hts product and α-spectrin as molecular components of fusomes, discovered a related structure in germline stem cells and documented regular associations...