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Keywords: Frizzled
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Journal Articles
Journal: Development
Development (2020) 147 (19): dev191981.
Published: 5 October 2020
... proteins. Conditional deletion of Wntless or porcupine, both of which are essential for secretion of Wnts, caused misrotated sensory cells and shortened cochlea – both hallmarks of PCP defects. Wntless-deficient cochleae lacked the polarized PCP components dishevelled 1/2 and frizzled 3/6, while other PCP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev168799.
Published: 16 December 2019
... deuterostome embryos strongly suggest that major aspects of the AP Wnt signaling network identified in sea urchin embryos may be conserved among deuterostome embryos ( Range, 2014 ). A combination of the activities of secreted Wnt modulators, trans-membrane Frizzled receptors and co-receptors is necessary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev174789.
Published: 9 August 2019
... is regulated by both long-range gradient-dependent and gradient-independent mechanisms. Morphogen gradient formation Wg Wnt Protein secretion Wing epithelium Drosophila Fz2 Frizzled Wnts are lipid-modified secreted proteins conserved in all metazoans and play a pivotal role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev168294.
Published: 29 April 2019
..., and resulted in loss of polarized rosette structures in the aggregates. Mutation in frizzled9b reduced total kidney nephron number, caused defects in tubule morphology and reduced regeneration of new nephrons after injury. Our results demonstrate an essential role for Wnt/frizzled signaling in adult zebrafish...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (24): dev168666.
Published: 17 December 2018
...Chun-Wei He; Chien-Po Liao; Chung-Kuan Chen; Jérôme Teulière; Chun-Hao Chen; Chun-Liang Pan ABSTRACT Signaling that instructs the migration of neurons needs to be tightly regulated to ensure precise positioning of neurons and subsequent wiring of the neuronal circuits. Wnt-Frizzled signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168229.
Published: 10 December 2018
... work is properly attributed. Dachsous Fat Four-jointed Frizzled Starry-night Van Gogh ‘ Polarity is in my mind the essential problem. We have to explain why one part of a cell becomes different from another part .’       Sydney Brenner (1994) Imagine how tricky it would...
Journal Articles
Journal: Development
Development (2018) 145 (23): dev169326.
Published: 3 December 2018
...Sergio Garrido-Jimenez; Angel-Carlos Roman; Alberto Alvarez-Barrientos; Jose Maria Carvajal-Gonzalez ABSTRACT In vertebrates, planar polarization of ciliary basal bodies has been associated with actin polymerization that occurs downstream of the Frizzled-planar cell polarity (Fz-PCP) pathway...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2012) 139 (23): 4374–4382.
Published: 1 December 2012
... cortical actin organisation. Morpholino antisense oligonucleotide and mRNA injection studies showed that PCP development requires the Clytia orthologues of the core Fz-PCP pathway components Strabismus (CheStbm), Frizzled (CheFz1) and Dishevelled (CheDsh). Morpholinos targeting any of these components...
Journal Articles
Journal: Development
Development (2011) 138 (13): 2751–2759.
Published: 1 July 2011
... – the Dachsous (Ds) and Frizzled (Fz) systems – play key roles in the establishment and maintenance of such polarity. There has been great progress in uncovering the how these genes work together to produce planar polarity, yet fundamental questions remain unanswered. Here, we study the Drosophila larval ventral...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (20): 3411–3415.
Published: 15 October 2010
...) Dachsous Fat Frizzled Gradients Starry night (Flamingo) Drosophila Planar cell polarity (PCP) is likely to be a property of all or most epithelial cells, even though they do not always evince it ( Lawrence et al., 2007 ). Some cells reveal their polarity by indicators; examples...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (5): 745–754.
Published: 1 March 2010
...-endocytosis of Ed and Fmi provides a link between apicobasal polarity and PCP. Echinoid Flamingo (Starry night) DE-cadherin (Shotgun) Frizzled Planar cell polarity Endocytosis Cell adhesion Adherens junction Drosophila Epithelial cells are polarized cells with different...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2008) 135 (18): 3103–3111.
Published: 15 September 2008
... localised core polarity protein Frizzled positively promotes prehair initiation, suggesting that both proximal and distal cellular cues act together to ensure accurate prehair placement. Patches of cells lacking stbm activity present the opposite situation, in which no proximal cue is present...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2007) 134 (17): 3055–3064.
Published: 1 September 2007
.... This is apparently due, in part, to a loss of regulation of Rho GTPase activity by the planar polarity receptor Frizzled,which itself becomes localised to the migratory edge of the border cells. We conclude that, during collective cell migration, the planar polarity pathway can mediate communication between motile...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (23): 4749–4759.
Published: 1 December 2006
... cerebral cortex, many wnt and frizzled family genes are expressed in gene-specific regional and lamina patterns( Shimogori et al., 2004 ). Such patterned expression suggests the possibility that these genes are involved in other aspects of brain development. Recent studies have shown that functional fzd3...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (22): 4561–4572.
Published: 15 November 2006
.... The other set, the Stan system, encodes Starry night (Stan or Flamingo) and Frizzled. The prevailing view is that the Ds system acts via the Stan system to orient cells. However, using the Drosophila abdomen, we find instead that the two systems operate independently: each confers and propagates polarity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (18): 3723–3732.
Published: 15 September 2006
... is unknown. Here, we report that the Wnt signal is transduced in muscle progenitor cells by at least two Frizzled (Fz)receptors (Fz1 and/or Fz6), through the canonical β-catenin pathway, in the epaxial domain of newly formed somites. We show that Myf5 activation is dramatically reduced by blocking the Wnt/β...
Journal Articles
Journal: Development
Development (2006) 133 (12): 2315–2324.
Published: 15 June 2006
... Four-jointed Dachs Frizzled Grunge Atrophin The Drosophila proteins Fat (Ft) and Dachsous (Ds) are required in several processes during the development of imaginal disc tissues. First, they help regulate the growth of discs. Removal of Ft and, to a lesser extent, Ds,induces...
Includes: Supplementary data