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Keywords: Frizzled
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Journal Articles
Journal: Development
Development (2020) 147 (19): dev191981.
Published: 5 October 2020
... proteins. Conditional deletion of Wntless or porcupine, both of which are essential for secretion of Wnts, caused misrotated sensory cells and shortened cochlea – both hallmarks of PCP defects. Wntless-deficient cochleae lacked the polarized PCP components dishevelled 1/2 and frizzled 3/6, while other PCP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev168799.
Published: 16 December 2019
... molecular mechanisms necessary for gastrulation and mesenchyme morphogenesis. Wnt signal transduction Anterior-posterior Deuterostome evolution Gene regulatory networks Wnt16 Frizzled In metazoans, anterior-posterior (AP) axis specification and patterning is one of the first fundamental...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev174789.
Published: 9 August 2019
... secretion Wing epithelium Drosophila Fz2 Frizzled Wnts are lipid-modified secreted proteins conserved in all metazoans and play a pivotal role in development and many diseases ( Nusse and Clevers, 2017 ; Zhan et al., 2017 ). The role of Wnt as a potential long-range signaling molecule has...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev168294.
Published: 29 April 2019
..., and resulted in loss of polarized rosette structures in the aggregates. Mutation in frizzled9b reduced total kidney nephron number, caused defects in tubule morphology and reduced regeneration of new nephrons after injury. Our results demonstrate an essential role for Wnt/frizzled signaling in adult zebrafish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (24): dev168666.
Published: 17 December 2018
...Chun-Wei He; Chien-Po Liao; Chung-Kuan Chen; Jérôme Teulière; Chun-Hao Chen; Chun-Liang Pan ABSTRACT Signaling that instructs the migration of neurons needs to be tightly regulated to ensure precise positioning of neurons and subsequent wiring of the neuronal circuits. Wnt-Frizzled signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168229.
Published: 10 December 2018
... bridges that span between neighbouring cells. Gradients across the tissue cause these bridges to be asymmetrically localised within each cell. Dachsous Fat Four-jointed Frizzled Starry-night Van Gogh ‘ Polarity is in my mind the essential problem. We have to explain why one part...
Journal Articles
Journal: Development
Development (2018) 145 (23): dev169326.
Published: 3 December 2018
...Sergio Garrido-Jimenez; Angel-Carlos Roman; Alberto Alvarez-Barrientos; Jose Maria Carvajal-Gonzalez ABSTRACT In vertebrates, planar polarization of ciliary basal bodies has been associated with actin polymerization that occurs downstream of the Frizzled-planar cell polarity (Fz-PCP) pathway...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (17): 3399–3409.
Published: 1 September 2014
... that the heterotrimeric G protein Go functions as a transducer of Wingless-Frizzled 2 signaling in the synapse. We identify Ankyrin 2 as a target of Go signaling required for NMJ formation. Moreover, the Go-ankyrin interaction is conserved in the mammalian neurite outgrowth pathway. Without ankyrins, a major switch...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (23): 4374–4382.
Published: 1 December 2012
... cortical actin organisation. Morpholino antisense oligonucleotide and mRNA injection studies showed that PCP development requires the Clytia orthologues of the core Fz-PCP pathway components Strabismus (CheStbm), Frizzled (CheFz1) and Dishevelled (CheDsh). Morpholinos targeting any of these components...
Journal Articles
Journal: Development
Development (2011) 138 (13): 2751–2759.
Published: 1 July 2011
... – the Dachsous (Ds) and Frizzled (Fz) systems – play key roles in the establishment and maintenance of such polarity. There has been great progress in uncovering the how these genes work together to produce planar polarity, yet fundamental questions remain unanswered. Here, we study the Drosophila larval ventral...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (20): 3411–3415.
Published: 15 October 2010
...) Dachsous Fat Frizzled Gradients Starry night (Flamingo) Drosophila Planar cell polarity (PCP) is likely to be a property of all or most epithelial cells, even though they do not always evince it ( Lawrence et al., 2007 ). Some cells reveal their polarity by indicators; examples...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (5): 745–754.
Published: 1 March 2010
... of Egfr. * Author for correspondence ( lshsu@life.nthu.edu.tw ) Competing interests statement 7 1 2010 © 2010. Echinoid Flamingo (Starry night) DE-cadherin (Shotgun) Frizzled Planar cell polarity Endocytosis Cell adhesion Adherens junction...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (12): 2121–2131.
Published: 15 June 2009
... of dscr5 disrupted Knypek membrane localization and caused an enhanced Frizzled 7 receptor endocytosis in a Caveolin-dependent manner. Furthermore, dscr5 knockdown promoted specific Dishevelled degradation by the ubiquitin-proteosome pathway. These results reveal a functional link between Knypek/Glypican 4...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (18): 3103–3111.
Published: 15 September 2008
... localised core polarity protein Frizzled positively promotes prehair initiation, suggesting that both proximal and distal cellular cues act together to ensure accurate prehair placement. An unexplained observation is that within stbm mutant tissue, the site of prehair initiation appears to be biased...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (2): 367–375.
Published: 15 January 2008
... of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein. The functional relationships among Fz, Lrp6 and Dvl have long been enigmatic. We demonstrated previously that Wnt-induced Lrp6 phosphorylation via glycogen synthase kinase 3 (Gsk3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (17): 3055–3064.
Published: 1 September 2007
.... This is apparently due, in part, to a loss of regulation of Rho GTPase activity by the planar polarity receptor Frizzled,which itself becomes localised to the migratory edge of the border cells. We conclude that, during collective cell migration, the planar polarity pathway can mediate communication between motile...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (23): 4749–4759.
Published: 1 December 2006
... markedly with their reported role in reintegration of neuroepithelial daughter cells into the neuroepithelial layer after cell division. * Author for correspondence (e-mail: hitoshi@brain.riken.jp ) 28 9 2006 © 2006. 2006 Zebrafish frizzled celsr Facial motor neuron...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (22): 4561–4572.
Published: 15 November 2006
.... The other set, the Stan system, encodes Starry night (Stan or Flamingo) and Frizzled. The prevailing view is that the Ds system acts via the Stan system to orient cells. However, using the Drosophila abdomen, we find instead that the two systems operate independently: each confers and propagates polarity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (18): 3723–3732.
Published: 15 September 2006
... is unknown. Here, we report that the Wnt signal is transduced in muscle progenitor cells by at least two Frizzled (Fz)receptors (Fz1 and/or Fz6), through the canonical β-catenin pathway, in the epaxial domain of newly formed somites. We show that Myf5 activation is dramatically reduced by blocking the Wnt/β...
Journal Articles
Journal: Development
Development (2006) 133 (12): 2315–2324.
Published: 15 June 2006
... Four-jointed Dachs Frizzled Grunge Atrophin We therefore next checked whether the deleted proteins retained the ability shown by full-length Ft or Ds to stabilize endogenous cell surface Ds or Ft,respectively, after misexpression in wing discs( Fig. 2A,D )( Matakatsu and Blair...
Includes: Supplementary data