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Keywords: Frazzled
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Journal Articles
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Reproductive biology
Journal: Development
Development (2021) 148 (24): dev199762.
Published: 15 December 2021
...Samantha A. Russell; Kaitlin M. Laws; Greg J. Bashaw ABSTRACT The Netrin receptor Frazzled/Dcc (Fra in Drosophila ) functions in diverse tissue contexts to regulate cell migration, axon guidance and cell survival. Fra signals in response to Netrin to regulate the cytoskeleton and also acts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2724–2733.
Published: 1 July 2013
... in midline-crossing (commissural) neurons. We find that Abl interacts both physically and genetically with the Netrin receptor Frazzled, and that disrupting this interaction prevents Abl from promoting midline axon crossing. Moreover, we find that Abl exerts its diverse activities through at least two...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (13): 2227–2235.
Published: 1 July 2010
... dorsal migration. Misexpression of Netrin-A in oenocytes, secretory cells that lie ventral to the cap cell, leads to aberrant cap cell morphogenesis, suggesting that Netrin-A acts as an instructive cue to direct the growth of the cap cell process. The netrin receptor Frazzled is required for normal cap...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (8): 1251–1262.
Published: 15 April 2010
... into the periphery. We further show that early Netrin-dependent guidance of LG requires expression of the receptor Frazzled (Fra) already in the precursor cell. At these early stages, Netrins are not yet expressed by cells of the ventral midline and we provide evidence for a novel Netrin source within the neurogenic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (24): 4325–4334.
Published: 15 December 2007
...David S. Garbe; Mike O'Donnell; Greg J. Bashaw The conserved DCC ligand-receptor pair Netrin and Frazzled (Fra) has a well-established role in axon guidance. However, the specific sequence motifs required for orchestrating downstream signaling events are not well understood. Evidence from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (8): 1983–1994.
Published: 15 April 2005
...David J. Forsthoefel; Eric C. Liebl; Peter A. Kolodziej; Mark A. Seeger The attractive Netrin receptor Frazzled (Fra), and the signaling molecules Abelson tyrosine kinase (Abl), the guanine nucleotide-exchange factor Trio,and the Abl substrate Enabled (Ena), all regulate axon pathfinding...
Includes: Supplementary data