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Keywords: Follistatin
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Journal Articles
Journal: Development
Development (2020) 147 (24): dev185827.
Published: 23 December 2020
... retinal organoids can self-organise in vitro . We identify a Pax6 Turing network that could explain both phenomena. Eye development Follistatin Pattern formation Pax6 Self-organisation TGFβ * Author for correspondence ( t.grocott@uea.ac.uk ) Handling Editor: James Briscoe...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev163014.
Published: 11 May 2018
... into type 1 cells (AT1s). BMP signaling is active in AT2s and TASCs, transiently declines post-PNX in association with upregulation of antagonists, and is restored during differentiation of AT2s to AT1s. In organoids, BMP4 inhibits AT2 proliferation, whereas antagonists (follistatin, noggin) promote AT2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (19): 4131–4142.
Published: 1 October 2011
... showed that a locally produced signal, the TGFβ superfamily ligand GDF11, regulates the genesis of olfactory receptor neurons by inhibiting proliferation of the immediate neuronal precursors (INPs) that give rise to them. GDF11 is antagonized by follistatin (FST), which is also produced locally. Here, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (9): 1453–1464.
Published: 1 May 2009
... of Gdf11 restoring substantial neurogenesis. Notably, we find no evidence for a disruption of Fgf8 expression in Foxg1 -/- OE. However, we do observe both a failure of expression of follistatin ( Fst ), which encodes a secreted Gdf11 antagonist normally expressed in and around OE, and an increase...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (17): 2959–2968.
Published: 1 September 2008
... (black) that showed the majority of these cells ( y -axis=cell counts) were CD29, CD44, CD54, CD105 and CD106 positive and CD45 negative. ( B ) Cultured iMSCs expressed genes encoding secreted Tgfβ inhibitors including follistatin (Fst) and follistatin-like 1 (Fstl1). Quantification of relative mRNA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 2905–2913.
Published: 1 August 2006
... by members of the TGFβ superfamily belonging to the BMP, GDF and activin subgroups. We show in particular that FGF8 tightly modulates follistatin expression, thus progressively restraining the inhibitory influence of activin B on RP differentiation. These regulations, together with FGF8 triggered apoptosis...
Journal Articles
Journal: Development
Development (2006) 133 (7): 1347–1357.
Published: 1 April 2006
... with the adult. We have also shown that both tbx1 and follistatin are expressed in a polarised fashion in both lamprey and zebrafish otic vesicles, suggesting that similar AP patterning mechanisms may function in the two species. The second striking aspect of the morphant phenotype concerns...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (5): 1041–1053.
Published: 1 March 2004
... by a PDZ domain. Because HtrA1 is a secretory protein and has another functional domain with homology to follistatin, we examined whether HtrA1 functions as an antagonist of Tgfβfamily proteins. During embryo development, mouse HtrA1 was expressed in specific areas where signaling by Tgfβ family proteins...