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Keywords: Fibrosis
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Journal Articles
Journal: Development
Development (2021) 148 (19): dev198937.
Published: 04 October 2021
... that impairs cardiac function. In other organisms, such as zebrafish, cardiac injury is followed by transient fibrosis and scar-free regeneration. The mechanisms that drive scarring versus scar-free regeneration are not well understood. Here, we show that the homeobox-containing transcription factor Prrx1b...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev167718.
Published: 25 February 2020
... have learnt about principles of regeneration from this new model. Spiny mouse Acomys Tissue regeneration Fibrosis Scarring The field of regenerative medicine aims to identify strategies to either engineer or repair human tissues, organs and body parts that cannot naturally...
Journal Articles
Journal: Development
Development (2011) 138 (17): 3625–3637.
Published: 01 September 2011
... of these cells for regeneration has not been tested. Connective tissue fibroblasts also are likely to play a role in regeneration, as connective tissue fibrosis is a hallmark of regenerating muscle. However, the lack of molecular markers for these fibroblasts has precluded an investigation of their role. Using...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (9): 1663–1674.
Published: 01 May 2011
... ventricular wall, suggesting that regeneration is associated with processes resembling mammalian ventricular remodeling after acute MI. Our results provide the first evidence that, like mammalian hearts, teleost hearts undergo massive fibrosis after cardiac damage. Unlike mammals, however, the fish heart can...
Includes: Multimedia, Supplementary data