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Development (2015) 142 (5): 817–831.
Published: 1 March 2015
... , C. , Hauschka , P. V. , Yayon , A. and Deng , C.-X. ( 1999 ). Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis . J. Clin. Invest. 104 , 1517 - 1525 . 10.1172/JCI6690 Chiang , C. , Litingtung , Y. , Lee , E...
Development (2007) 134 (16): 3021–3029.
Published: 15 August 2007
...), are arranged in adjacent rows that form a boundary between a single row of inner hair cells and three rows of outer hair cells (OHCs). PCs are required for auditory function, as mice lacking PCs owing to a mutation in Fgfr3 are deaf. Here, using in vitro and in vivo techniques, we demonstrate that an Fgf8...
Includes: Supplementary data
Nigel P. Pringle, Wei-Ping Yu, Marisa Howell, Jennifer S. Colvin, David M. Ornitz, William D. Richardson
Development (2003) 130 (1): 93–102.
Published: 1 January 2003
...Nigel P. Pringle; Wei-Ping Yu; Marisa Howell; Jennifer S. Colvin; David M. Ornitz; William D. Richardson The postnatal central nervous system (CNS) contains many scattered cells that express fibroblast growth factor receptor 3 transcripts ( Fgfr3 ). They first appear in the ventricular zone (VZ...
Development (2001) 128 (9): 1617–1627.
Published: 1 May 2001
... demonstrated to be necessary for endogenous initiation of fiber cell differentiation. To test this possibility, we have generated transgenic mice with ocular expression of secreted self- dimerizing versions of FGFR1 (FR1) and FGFR3 (FR3). Expression of FR3, but not FR1, leads to an expansion of proliferating...
Development (1999) 126 (24): 5611–5620.
Published: 15 December 1999
...S. Iseki; A. O. M. Wilkie; G. M. Morriss-Kay Fibroblast growth factor receptors (FGFRs) play major roles in skeletogenesis, and activating mutations of the human FGFR1, FGFR2 and FGFR3 genes cause premature fusion of the skull bones (craniosynostosis). We have investigated the patterns...
Development (1998) 125 (24): 4977–4988.
Published: 15 December 1998
...Michael C. Naski; Jennifer S. Colvin; J. Douglas Coffin; David M. Ornitz ABSTRACT Fibroblast growth factor receptor 3 (FGFR3) is a key regulator of skeletal growth and activating mutations in Fgfr3 cause achondroplasia, the most common genetic form of dwarfism in humans. Little is known about...