... , D. ( 2008 ). Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart . Dev. Biol.   321 , 397 - 406 . 10.1016/j.ydbio.2008.06.033 McInnes , L. , Healy , J. , Saul , N. and Großberger , L. ( 2018 ). UMAP: uniform manifold...

... be expanded as an in vitro model for naïve extra-embryonic endoderm (nEnd). Consistent with observations made in mouse, human PrE differentiation is dependent on FGF signalling in vitro , and we show that, by inhibiting FGF receptor signalling, we can simplify naïve pluripotent culture conditions...

.... , Ornitz , D. and Beebe , D. C. ( 2014 ). FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands . Development   141 , 2691 - 2701 . 10.1242/dev.108944 Gaete , M. , Fons , J. M. , Popa , E. M. , Chatzeli , L...

... of Tc-dof than Tc-htl ( Donitz et al., 2015 ; Schmitt-Engel et al., 2015 ). This indicates that Tc-dof is not required for all aspects of FGF signalling in Tribolium , which is in contrast to Drosophila where dof mutants almost completely abolish FGF signalling ( Imam et al., 1999 ; Vincent...

... by The Company of Biologists Ltd 2015 Summary: In the developing Drosophila eye, the TRF2 complex regulates downstream factors including Pdm3 and Cut to control glial proliferation and differentiation, respectively. Drosophila Glial proliferation Glial differentiation FGF signalling...

... as the neural programme is established. We further demonstrate that transcription of one such gene, HDAC1 , is dependent on FGF signalling, making a novel link between signals that control neural differentiation and transcription of a core regulator of chromatin organisation. Our work implicates new signalling...

... at position B-2 within the PSM. Heat-shock experiments, however, suggest that an earlier future somite boundary exists at B-5, but the molecular signature of this boundary remains unidentified. Here, we characterized fibroblast growth factor (FGF) signal activity within the PSM, and demonstrated...

... and gene knockdown and/or overexpression experiments, we demonstrate that Fgf signalling acts via another ETS-domain transcription factor, Etv5b (Erm), to induce hypothalamic 5-HT neurons. We provide evidence that Etv5b exerts its effects by regulating cell cycle parameters in 5-HT progenitors. Our results...

... boundary cells positions fgf20a neurons (red) in the segment centre. The cluster of fgf20a neurons creates a focussed source of FGF signals (red lines) that inhibit neurogenesis in the adjacent neural epithelium, restricting the neurogenic zones (green) to being adjacent to boundaries. ( C , D...

...Fabian Rentzsch; Jens H. Fritzenwanker; Corinna B. Scholz; Ulrich Technau Fibroblast growth factor (FGF) signalling regulates essential developmental processes in vertebrates and invertebrates, but its role during early metazoan evolution remains obscure. Here, we analyse the function of FGF...

... of Fgf signalling at distinct points of the MAPK signalling cascade in the neck lateral mesoderm and ectoderm. * Author for correspondence (e-mail: susanne.dietrich@kcl.ac.uk ) 5 10 2005 ©2005. 2005 To detect activated MAPK signalling, rapid fixation in 4% PFA was required...

... specification and differentiation. * Author for correspondence (e-mail: a.munsterberg@uea.ac.uk ) 14 1 2005 ©2005. 2005 FGF signalling Chick Somite Tendon Rib Mkp3 ERK MAP kinase Scleraxis During vertebrate embryogenesis, epithelial somites are generated sequentially...

... to be responsible for the apoptotic signal/s of cavitation; the second, originating in the BM, was considered necessary for the maintenance and survival of the columnar ectoderm( Coucouvanis and Martin,1995 ). The work to be described here started as a study of the role of FGF signalling in EB differentiation...

...Matthias Carl; Joachim Wittbrodt Signalling by fibroblast growth factors (FGFs) at the mid-hindbrain boundary (MHB) is of central importance for anteroposterior neural patterning from the isthmic organiser. Graded suppression of FGF signalling by increasing amounts of a dominant negative FGF...