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Keywords: Fgf
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Journal Articles
Journal: Development
Development (2024) 151 (4): dev202183.
Published: 13 February 2024
.... Previous studies in zebrafish have shown that sustained FGF signaling acts upstream of Nkx factors to maintain ventricular identity, but the rest of this maintenance pathway remains unclear. Here, we show that MEK1/2-ERK1/2 signaling acts downstream of FGF and upstream of Nkx factors to promote ventricular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2024) 151 (3): dev202123.
Published: 7 February 2024
... that, in the mouse lens, membrane protrusions or lamellipodia are observed only in the maturing fibers undergoing cell curve conversion, indicating that lamellipodium formation is not the primary driver of earlier fiber migration. We demonstrated that elevated levels of fibroblast growth factor (FGF) suppressed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2024) 151 (1): dev202249.
Published: 5 January 2024
... to heterochromatin domains across master-regulator transcription factor gene bodies, suggesting it safeguards epithelial cell fate. Moreover, we demonstrate that FGF hyper-stimulation in vivo leads to MAF network activation and the emergence of novel lens cell states. Collectively, these data depict a comprehensive...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2023) 150 (11): dev201284.
Published: 1 June 2023
... branching are controlled by MAPK/ERK and PI3K/AKT signalling. Organoid EGF FGF Integrin KTR reporter Wellcome Trust http://dx.doi.org/10.13039/100010269 109146/Z/15/Z University of Cambridge http://dx.doi.org/10.13039/501100000735 Medical Research Council MR...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (10): dev201023.
Published: 16 May 2023
... are a predominant cause of congenital thyroid diseases. The first molecularly recognizable step of thyroid development is the specification of thyroid precursors in anterior foregut endoderm. Recent studies have identified crucial roles of FGF and BMP signaling in thyroid specification, but the interplay between...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (6): dev201293.
Published: 20 March 2023
...Ayan T. Ray; Philippe Soriano ABSTRACT Loss of FGF signaling leads to defects in salivary gland branching, but the mechanisms underlying this phenotype remain largely unknown. We disrupted expression of Fgfr1 and Fgfr2 in salivary gland epithelial cells and found that both receptors function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (17): dev200767.
Published: 12 September 2022
... changes in explant cultures of wild-type ureters. Additional experiments suggest that mesenchymal FGFR1 and FGFR2 act as a sink for FGF ligands to dampen activation of Shh and BMP receptor gene expression by epithelial FGFR2 signaling. * Author for correspondence ( kispert.andreas@mh-hannover.de...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev200021.
Published: 12 January 2022
...-dependent manner. Our study suggests that FGF signals from the mesenchyme enhance, via epithelial FGFR2, the SHH-BMP4 signaling axis to drive urothelial and mesenchymal development in the early ureter. * These authors contributed equally to this work ‡ Author for correspondence ( kispert.andreas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (23): dev199544.
Published: 2 December 2021
... Highlighted Article: A new comparative system for understanding branching morphogenesis is provided in the Cladonema pacificum medusa tentacle formation, showing its uniqueness and shared features with others. Branching morphogenesis FGF Interstitial cells Cladonema pacificum Medusa tentacle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev195651.
Published: 23 April 2021
... E10.5. Expression analyses revealed partly disturbed regionalisation, and a posterior-ventral expansion of the neurogenic domain in Tbx2/3cDKO otocysts at this stage. We provide evidence that repression of FGF signalling by TBX2 is important to restrict neurogenesis to the anterior-ventral otocyst...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev186916.
Published: 16 April 2021
... and organisms, and discusses the extent to which these processes are conserved between tendons and ligaments. Tendon Ligament Enthesis Scx Tenocyte Fibrous connective tissue Fgf Tendons and ligaments are closely related dense fibrous connective tissues that play vital roles...
Journal Articles
Journal: Development
Development (2020) 147 (17): dev188094.
Published: 11 September 2020
...Olga Ossipova; Keiji Itoh; Aurelian Radu; Jerome Ezan; Sergei Y. Sokol ABSTRACT Among the three embryonic germ layers, the mesoderm plays a central role in the establishment of the vertebrate body plan. The mesoderm is specified by secreted signaling proteins from the FGF, Nodal, BMP and Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184689.
Published: 28 April 2020
...Daniel P. S. Osborn; Kuoyu Li; Stephen J. Cutty; Andrew C. Nelson; Fiona C. Wardle; Yaniv Hinits; Simon M. Hughes ABSTRACT Skeletal muscle derives from dorsal mesoderm formed during vertebrate gastrulation. Fibroblast growth factor (Fgf) signalling cooperates with Tbx transcription factors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev184507.
Published: 6 April 2020
... and myoblast pools. We reveal that the non-cell-autonomous effect of MyHC-emb on myogenic progenitors and myoblasts is mediated by the fibroblast growth factor (FGF) signaling pathway, and exogenous FGF rescues the myogenic differentiation defects upon loss of MyHC-emb function in vitro . Adult Myh3 null mice...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev171405.
Published: 21 November 2019
... of ectopic pineal progenitors. We also demonstrate that fibroblast growth factors (FGFs) position the pineal progenitor domain within the non-neural border by repressing pineal fate and that the Otx transcription factors promote pinealogenesis by inhibiting this FGF activity. The non-neural origin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev183269.
Published: 8 November 2019
... cohesiveness. We reveal that cadherin switching diminishes the level of nuclear β-catenin, and that N-cadherin also dampens FGF activity and consequently stabilises neural fate. Finally, we compare the timing of cadherin switching and differentiation in vivo and in vitro , and find that this process becomes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev170241.
Published: 2 August 2019
... demonstrate that development of Scx + /Sox9 + progenitors within the mammalian lower jaw requires FGF signaling. We find that loss of Fgfr2 in the mouse tendon-bone interface reduces Scx expression in Scx + /Sox9 + progenitors and induces their biased differentiation into Sox9 + chondrocytes. This expansion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev177295.
Published: 16 July 2019
...Frank Macabenta; Angelike Stathopoulos ABSTRACT In Drosophila embryos, caudal visceral mesoderm (CVM) cells undergo bilateral migration along the trunk visceral mesoderm (TVM) in order to form midgut muscles. Mutation of FGF receptor Heartless (Htl) has been shown to cause CVM migration defects...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev173575.
Published: 10 May 2019
... at the ciliated LR organizer (LRO). Although the role of fibroblast growth factor (FGF) signaling pathways during mesoderm development is conserved, diverging results from different model organisms suggest a non-conserved function in LR asymmetry. Here, we demonstrate that FGF is required during gastrulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev171496.
Published: 11 February 2019
... in the mesenchyme leads to the loss of basal cells and cartilage, concomitant with reduced transcript levels of Fgf10 in Dermo1-Cre;Ctnnb1 loxp/loxp mutants. Furthermore, deletion of Fgf receptor 2 ( Fgfr2 ) in the epithelium also leads to significantly reduced numbers of basal cells, supporting the importance...
Includes: Supplementary data