...Robert N. Kelsh; Karen Camargo Sosa; Saeed Farjami; Vsevolod Makeev; Jonathan H. P. Dawes; Andrea Rocco ABSTRACT Neural crest cells are crucial in development, not least because of their remarkable multipotency. Early findings stimulated two hypotheses for how fate specification and commitment from...

...Julia Kofent; Juan Zhang; Francesca M. Spagnoli Cell fate specification depends on transcriptional activation driven by lineage-specific transcription factors as well as changes in chromatin organization. To date, the interplay between transcription factors and chromatin modifiers during...

... derived from individual blastomeres of 8- and 12-cell human embryos have unique properties, provide insights into early human embryogenesis and enable human trophoblast stem cell derivation. Human embryo Blastomere Human embryonic stem cell Human trophoblast stem cell Fate specification...

..., notably activator inputs mediated by Sox2, is probably a key mechanism in achieving cell type-specific transcriptional outcomes in mammalian neural progenitor fate specification. Neural progenitors were derived from mESCs in serum-free suspension culture in all-trans retinoic acid (RA, Sigma; 500 nM...

... interneurons Embryonic stem cells Fate specification Parvalbumin Somatostatin Sonic hedgehog Mouse In the mammalian neocortex, GABAergic cortical interneurons (cINs) facilitate cognition by providing inhibitory inputs to cortical circuitry ( Lehmann et al., 2012 ; Fino et al., 2013...

... have isolated a novel sox10 mutant that lacks glia and yet displays a neurogenic DRG phenotype. In conjunction with previous findings, these data establish the generality of our model of Sox10 function in NC fate specification. * Author for correspondence (e-mail: bssrnk@bath.ac.uk ) 21 9...

...-cell fate is suggested. * Author for correspondence (e-mail: amansou@gwdg.de ) 19 4 2005 ©2005. 2005 Endocrine pancreas development Arx Pax4 Mouse Hyperglycaemia Fate specification The pancreas plays a key role in the maintenance of nutritional homeostasis...

... whether these proteins function primarily in fate specification, cell death, division, or other developmental processes. The fact that similar proteins are involved in skeletogenesis in sea urchins and vertebrates raises the possibility there might be an evolutionary link between certain features...

... failure to activate MITF in the normal number of melanoblasts. ‡ Authors for correspondence (e-mail: bssrnk@bath.ac.uk and draible@u.washington.edu ) 26 2 2003 © 2003. 2003 Zebrafish Danio rerio Neural crest Fate specification Melanocyte sox10 colourless mitf...

.... Since lin-11 is also expressed in the ASG lineal sisters of the AWA neurons, we examined whether ASG cell fate specification requires lin-11 function, by examining expression of ASG markers in lin-11 mutants. Markers examined include ops-1 ::GFP (see Materials and Methods), unc-30 ::GFP...