...: We have developed a new transgenic technique for simultaneous labelling of all three germ layers in mice that overcomes the difficulties of conventional single-gene tracing systems in precision lineage tracing. Lineage-tracing system Fate map Germ layer 2A peptide Site-specific recombinase...

...Iain Martyn; Eric D. Siggia; Ali H. Brivanlou ABSTRACT Although fate maps of early embryos exist for nearly all model organisms, a fate map of the gastrulating human embryo remains elusive. Here, we use human gastruloids to piece together a rudimentary fate map for the human primitive streak (PS...

... mesodermal subcompartments in males and females, and that <50% of interscapular brown fat arises from central dermomyotome. Adipocyte Adipose Fate map Lineage tracing Mesoderm Appropriate developmental patterning of adipose tissue results in a stereotyped anatomical configuration...

... ) and developing brain homeobox 1 ( Dbx1 ). Utilizing simultaneous dual and intersectional fate mapping, we demonstrate that this boundary is precisely formed with minimal overlap between En1 and Dbx1 microdomains, unlike many other boundaries. We show that the En1 microdomain gives rise to dopaminergic (DA...

...Luisa Sanchez-Arrones; Claudio D. Stern; Paola Bovolenta; Luis Puelles The anterior border of the neural plate, presumed to contain the prospective peripheral portion (roof) of the prospective telencephalon, emerges within a vaguely defined proneural ectodermal region. Fate maps carried out at HH4...

..., expression patterns of anterior ectoderm genes overlap significantly and correlate with areas of distinct prospective fates but do not define lineages. The fate map delineates a rostral limit to forebrain contribution. However, no early subdivision of the presumptive forebrain territory can be detected...

... of the invaginating optic cup. We identify unanticipated movements, particularly of central and peripheral retina, RPE and lens. From cell tracking data, we generate retina, RPE and lens subdomain fate maps, which reveal novel adjacencies that might determine corresponding developmental signaling events. Finally, we...

... for the boundary formation by fate mapping Gbx2 -transcribing cells in Gbx2 CreER/- ; R26R embryos, which lack Gbx2 function( Fig. 1C,D ). When tamoxifen was administered to pregnant Gbx2 +/- females that were mated with Gbx2 CreER/+ ; R26R -/- males at E10.5, the distribution of β-gal-positive cells...

...), diencephalon (3rd ventricle) and dorsomedial telencephalon bilaterally (lateral ventricles). All of these sites lie at or near the embryonic dorsal midline (DM), which acts as a CNS patterning center. We therefore examined DM-CP relationships using normal and Gdf7 (Bmp12)transgenic embryos to fate map...

... to fate map the oral epithelium in chick embryos, we show that the cells that will occupy the epithelium of the distal and the proximal mandible primordium already occupy different spatial locations in the developing head ectoderm prior to the formation of the first pharyngeal arch and neural crest...

... consisting of two tissue layers, the myocardium and endocardium. The cellular and molecular mechanisms responsible for the separation of ventricular and atrial lineages are not well understood. To test models of cardiac chamber specification, we generated a high-resolution fate map of cardiac chamber...

... germ layers and different numbers of cells are used to generate the germ layers. For reasons of space, only comparisons for the endoderm and germ line are discussed here. Fig. 8. Crustacean fate maps and various cell lineages. (A,C,E,G,I) Fate maps from crustacean taxa that possess total...

... Genetic mosaic Fate map Genetic redundancy Genetic synergy Zebrafish T-box transcription factors are a large family of transcriptional regulators involved in many aspects of embryonic development ( Smith, 1999 ). The founding family member, Brachyury (or T ), was originally identified...

...Alexandria Saulsberry; Paula R. Martin; Tim O’Brien; Leslie E. Sieburth; F. Bryan Pickett Creation of an embryonic fate map may provide insight into the patterns of cell division and specification contributing to the apical region of the early Arabidopsis embryo. A fate map has been constructed...

...Pedro Fernández-Garre; Lucia Rodríguez-Gallardo; Victoria Gallego-Díaz; Ignacio S. Alvarez; Luis Puelles A detailed fate map was obtained for the early chick neural plate (stages 3d/4). Numerous overlapping plug grafts were performed upon New-cultured chick embryos, using fixable...

... of fate mapping, gene expression pattern analyses and tests of gene function lead us to favor the latter mechanism for specification of hypochord cells in zebrafish. Specifically, we propose that, during gastrulation, high levels of Delta signals from paraxial mesoderm induce neighboring midline...

... 7 2001 © 2001. 2001 Ganglionic eminences Neocortical development Tangential neuronal migration Ultrasound Fate map Non-pyramidal Interneurons Medium spiny neurons GABA Parvalbumin Somatostatin DARPP-32 Mouse Cell migration is an important determinant of brain...

...Abhay Redkar; Michael Montgomery; Judith Litvin Cardiogenic fate maps are used to address questions on commitment, differentiation, morphogenesis and organogenesis of the heart. Recently, the accuracy of classical cardiogenic fate maps has been questioned, raising concerns about the conclusions...

... 2000 © 2000 by Company of Biologists 2000 distal-less 3 fate map lineage tracing telencephalon In vertebrates, some derivatives of the peripheral nervous system (PNS), including primary sensory neurons of the inner ear and the olfactory epithelium, develop from specialized...

...Robert Woodrick; Paula R. Martin; Ilya Birman; F. Bryan Pickett ABSTRACT A fate map has been constructed for the shoot apical region of the embryo of the dicotyledonous plant Arabidopsis thaliana using spontaneously arising clonal albino sectors caused by the chloroplast mutator 1-2 mutation...