... crossing an HA Frankenbody fly with an HA-tagged POI fly. Strikingly, the GFP-mCherry tandem fluorescent-tagged HA Frankenbody revealed a block in autophagic flux and an accumulation of enlarged autolysosomes in the last instar larval and prepupal fat body. Mechanistically, lysosomal activity...

...Zhongxia Wu; Qiongjie He; Baojuan Zeng; Haodan Zhou; Shutang Zhou ABSTRACT Vitellogenin (Vg) is a prerequisite for egg production and embryonic development after ovipositioning in oviparous animals. In many insects, juvenile hormone (JH) promotes fat body cell polyploidization for the massive Vg...

... is stored in two different forms: the disaccharide trehalose and the branched polymer glycogen. Glycogen is synthesized and stored in several tissues, including in muscle and the fat body. Despite the major role of the fat body as a center for energy metabolism, the importance of its glycogen content...

... that the fly fat body, which is functionally equivalent to the mammalian liver, also contributes to tracheal morphogenesis. Serp was expressed by the fat body, and the secreted Serp was taken up by the tracheal cells and translocated to the lumen to functionally support normal tracheal development...

..., but its molecular mechanism remains conjectural. Here we report that genetic ablation of the corpus allatum cells of the Drosophila ring gland (the JH source) resulted in JH deficiency, pupal lethality and precocious and enhanced programmed cell death (PCD) of the larval fat body. In the fat body...

.... Drosophila CYLD is broadly expressed during development and, in adult animals, is localized in the fat body,ovaries, testes, digestive tract and specific areas of the nervous system. We demonstrate that the protein product of Drosophila CYLD (CYLD), like its mammalian counterpart, is a deubiquitylating...

... of cell division. Hemizygous dm 4 /Y mutants arrest as second instar larvae, and fat body nuclei of dm 4 /Y mutants fail to attain normal size and normal levels of DNA, resulting from a reduced frequency of S-phase. Thus, dMyc is required for endoreplication and larval growth. In support of this, dMyc...

...Marcella Marchetti; Laura Fanti; Maria Berloco; Sergio Pimpinelli We have analyzed the expression of homeotic Bithorax Complex proteins in the fat bodies of Drosophila larvae by staining with specific antibodies. We have found that these proteins are differentially expressed along...

... or lipid breakdown. The pumpless gene is expressed specifically in the fat body and encodes a protein with homology to a vertebrate enzyme involved in glycine catabolism. Feeding wild-type larvae high levels of amino acids could phenocopy the feeding and growth defects of pumpless mutants. Our data suggest...

... in the embryonic yolk cells and in the fat body of the embryo and larva. The predicted molecular structure, expression patterns, and mitogenic activity of these proteins suggest that they are secreted and transported to target tissues via the hemolymph. However, the genes are also expressed in embryonic epithelia...

... the anteroposterior and dorsoventral axes. The exact developmental pathways that guide the specification of different cell types within the mesoderm are not well understood. We have analyzed the developmental relationship between two mesodermal tissues in the Drosophila embryo, the gonadal mesoderm and the fat body...

...Veit Riechmann; Klaus-Peter Rehorn; Rolf Reuter; Maria Leptin ABSTRACT The somatic muscles, the heart, the fat body, the somatic part of the gonad and most of the visceral muscles are derived from a series of segmentally repeated primordia in the Drosophila mesoderm. This work describes the early...

...Veit Riechmann; Uwe Irion; Robert Wilson; Ruth Grosskortenhaus; Maria Leptin ABSTRACT The primordia for heart, fat body, and visceral and somatic muscles arise in specific areas of each segment in the Drosophila mesoderm. We show that the primordium of the somatic muscles, which expresses high...

... suggest that it is an ortholog of the entire ver-tebrate Gata family. srp is required for the differentiation and morphogenesis of the endodermal gut. Here we show that it is also essential for Drosophila hematopoiesis and for the formation of the fat body, the insect organ analogous to the liver...

...Deborah Keiko Hoshizaki; Thomas Blackburn; Catherine Price; Mita Ghosh; Kathy Miles; Mark Ragucci; Rami Sweis ABSTRACT The Drosophila adipose tissue, or fat body, and the body-wall muscle are two major tissues derived from the mesoderm. Although much is known about the lineage of muscle cells...

... support of a role for ABF in the regulation of Adh expression, ABF mRNA is expressed in the embryonic fat body, a tissue that contains high levels of Adh mRNA. Our studies demonstrate that the fat body develops from segmentally repeated clusters of mesodermal cells, which later expand and coalesce to form...

... 1992 by Company of Biologists 1992 ecdysone Eip28/29 Eip40 rp49 Drosophila ecdysone-inducible polypeptides lymph gland hemocytes proventriculus epidermis midgut Malpighian tubules fat body late 3 rd transition From a developmental perspective, the most remarkable...