...Sami A. Leino; Sean C. J. Constable; Andrea Streit; David G. Wilkinson ABSTRACT Developing tissues are sequentially patterned by extracellular signals that are turned on and off at specific times. In the zebrafish hindbrain, fibroblast growth factor (Fgf) signalling has different roles at different...

... genes induced by Fgf signalling ( Fig. S12 ). In situ hybridisation confirmed that Fgf20 signalling is both necessary and sufficient for expression of etv5b , metrnla and fsta in segment centres ( Fig. 6 H-P). metrnla encodes a cytokine with an unknown receptor. As the related meteorin gene...

... be expanded as an in vitro model for naïve extra-embryonic endoderm (nEnd). Consistent with observations made in mouse, human PrE differentiation is dependent on FGF signalling in vitro , and we show that, by inhibiting FGF receptor signalling, we can simplify naïve pluripotent culture conditions...

... of Sox9 in the salivary gland epithelium results in loss of the distal epithelial progenitors, a reduction in proliferation and a subsequent failure in branching in mice. Branching morphogenesis Epithelial progenitors Sox9 Fgf signalling Salivary glands To develop therapeutic strategies...

...., 2015 ). Thus, in Tribolium , Tc-twi appears to be required for the formation of the CVM and this effect is probably not only indirect through regulation of FGF signalling by Tc-twi , but also direct since the CVM precursor cells express Tc-twi . In contrast, in Drosophila , the CVM cells do...

... differentiation FGF signalling Transcription factors Pdm3 Dref Cut The specification of different neural cell types is a major step during the development of the nervous system. A first decision takes place on the level whether a neural cell develops into a neuron or a glial cell. Whereas...

... as the neural programme is established. We further demonstrate that transcription of one such gene, HDAC1 , is dependent on FGF signalling, making a novel link between signals that control neural differentiation and transcription of a core regulator of chromatin organisation. Our work implicates new signalling...

... at position B-2 within the PSM. Heat-shock experiments, however, suggest that an earlier future somite boundary exists at B-5, but the molecular signature of this boundary remains unidentified. Here, we characterized fibroblast growth factor (FGF) signal activity within the PSM, and demonstrated...

... and gene knockdown and/or overexpression experiments, we demonstrate that Fgf signalling acts via another ETS-domain transcription factor, Etv5b (Erm), to induce hypothalamic 5-HT neurons. We provide evidence that Etv5b exerts its effects by regulating cell cycle parameters in 5-HT progenitors. Our results...

... ). In fgf20a mutant embryos, ectopic neurogenesis occurs throughout segment centres, probably owing to a lack of inhibition of neuronal differentiation rather than to altered proliferation of a progenitor population, as FGF signalling does not affect hindbrain cell proliferation at these stages ( Gonzalez...

...Fabian Rentzsch; Jens H. Fritzenwanker; Corinna B. Scholz; Ulrich Technau Fibroblast growth factor (FGF) signalling regulates essential developmental processes in vertebrates and invertebrates, but its role during early metazoan evolution remains obscure. Here, we analyse the function of FGF...

... of Fgf signalling at distinct points of the MAPK signalling cascade in the neck lateral mesoderm and ectoderm. Whole-mount tracing of the nervous system was carried out according to Guthrie and Lumsden ( Guthrie and Lumsden,1992 ), using the RMO270 antibody (Zymed), which recognizes the 155 kDa...

.... Asterisks indicate missing ribs (B,C,E,H) compared with rib present in control (G). dm,dermomyotome; my, myotome; sc, sclerotome. * Author for correspondence (e-mail: a.munsterberg@uea.ac.uk ) 14 1 2005 ©2005. 2005 FGF signalling Chick Somite Tendon Rib Mkp3 ERK MAP...

... multiple steps in embryonic development and malignant transformation. Cell 95 , 793 -803. Ciruna, B. and Rossant, J. ( 2001 ). FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev. Cell 1 , 37 -49. Clark, E. A., Golub, T. R...

...Matthias Carl; Joachim Wittbrodt Signalling by fibroblast growth factors (FGFs) at the mid-hindbrain boundary (MHB) is of central importance for anteroposterior neural patterning from the isthmic organiser. Graded suppression of FGF signalling by increasing amounts of a dominant negative FGF...

...Catherine Launay; Valérie Fromentoux; De-Li Shi; Jean-Claude Boucaut ABSTRACT We have examined the role of fibroblast growth factor (FGF) signalling in neural induction. The approach takes advantage of the fact that both noggin and the dominant negative mutant activin receptor (Δ 1XAR1 ) directly...