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Keywords: FGF signaling
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Neural development
Journal: Development
Development (2024) 151 (2): dev202043.
Published: 11 January 2024
... signaling appears to be one of the important regulators. Fgfr2 is expressed in the progenitor cells during tooth root development. Loss of FGF signaling leads to shortened roots with compromised proliferation and differentiation of progenitor cells. Furthermore, Hh signaling is impaired in Gli1-Cre ER...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (12): dev200349.
Published: 28 June 2022
... with ribosome biogenesis. We discovered that the half-life of fgf8a mRNA was reduced in ncl −/− mutants, which perturbed Fgf signaling, resulting in misregulated Sox9a-mediated chondrogenesis and Runx2-mediated osteogenesis. Consistent with this model, exogenous FGF8 treatment significantly rescued...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (21): dev199926.
Published: 5 November 2021
... for FGF signaling that might operate in a range of developing tissues. Doxycycline-inducible GATA4 -mCherry-inducible ESCs were generated by electroporation of 50,000 E14tg2a ESCs with 4 µg pPB-TET-GATA4-mCherry, 4 µg pCAG-rtTA-Neo and 4 µg pCAG-PBase ( Wang et al., 2008 ), followed by G418 selection...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev183624.
Published: 7 February 2020
.... Although this process of myotube guidance is essential to pattern the musculoskeletal system, the mechanisms that control myotube guidance remain poorly understood. Using transcriptomics, we found that components of the Fibroblast Growth Factor (FGF) signaling pathway were enriched in nascent myotubes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev181032.
Published: 17 January 2020
... into adulthood. FGF signaling Lung development Myofibroblast Lipofibroblast Lineage tracing Alveolar macrophage Lung development results in an organ with the capacity to support efficient gas exchange in a mature animal. This is facilitated by the alveoli, the functional unit of air-gas...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (24): 4563–4572.
Published: 15 December 2017
... compared with earlier steps in lung development. FGF signaling through receptors Fgfr3 and Fgfr4 is crucial for alveologenesis, but the mechanisms through which they mediate this process remain unclear. Here we show that in Fgfr3;Fgfr4 ( F gfr3;4 ) global mutant mice, alveolar simplification is first...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2982–2993.
Published: 15 August 2017
... http://www.biologists.com/user-licence-1-1/ Summary: Bmp4 activates the mesoderm progenitor gene network via key regulators, such as brachyury and Nkx1-2, and prevents premature differentiation to mesodermal-derived lineages. Bmp signaling Fgf signaling Mesoderm progenitor...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (14): 2561–2572.
Published: 15 July 2016
... that exposure of mouse embryos to short-term gestational hypoxia induces the most common types of heart defect. This is mediated by the rapid induction of the unfolded protein response (UPR), which profoundly reduces FGF signaling in cardiac progenitor cells of the second heart field. Thus, UPR activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (11): 2000–2011.
Published: 1 June 2016
... is necessary for pouch outpocketing via the Fibroblast growth factor (Fgf) pathway. Double loss-of-function analyses demonstrate that Bmp and Fgf signaling interact synergistically in craniofacial development. Collectively, our analyses shed light on the tissue and signaling interactions that regulate...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (13): 2611–2620.
Published: 1 July 2014
... ( eldad.tzahor@weizmann.ac.il ) Competing interests The authors declare no competing financial interests. 12 12 2013 30 4 2014 © 2014. Published by The Company of Biologists Ltd 2014 ERK FGF signaling Myogenesis Chick Mouse Myogenesis, the formation of muscle tissue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1381–1391.
Published: 15 March 2014
... ). fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo . Nature 427 , 419 – 422 . Dubrulle J. , McGrew M. J. , Pourquié O. ( 2001 ). FGF signaling controls somite boundary position and regulates segmentation clock control...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (14): 2576–2583.
Published: 15 July 2012
... to this work ‡ Author for correspondence ( j.deschamps@hubrecht.eu ) Competing interests statement The authors declare no competing financial interests. 5 5 2012 © 2012. 2012 Embryonic axial elongation Posterior growth zone Cdx and Hox genes Fgf signaling Post-occipital...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2012) 139 (12): 2210–2220.
Published: 15 June 2012
... Repressive Complex 1 (PRC1), is essential for pectoral fin development. We show that differentiation of lateral plate mesoderm (LPM) cells into presumptive pectoral fin precursors is initiated normally in ring1b mutants, but fin bud outgrowth is impaired. Fgf signaling, which is essential for migration...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2012) 139 (4): 699–708.
Published: 15 February 2012
... CVM and TVM cells, respectively, suggested FGF signaling may influence CVM cell guidance. In FGF mutants, CVM cells die before reaching the anterior region of the TVM. However, an earlier phenotype observed was that the two cell clusters lose direction and converge at the midline. Live in vivo imaging...
Includes: Multimedia, Supplementary data