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Keywords: Extracellular matrix
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Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (14): dev201304.
Published: 13 July 2023
..., but that neural crest migration is strikingly disrupted in double cdon ; boc mutant embryos. We further show that this migration phenotype is associated with defects in the differentiation of slow-twitch muscle cells, and the loss of a Col1a1a-containing extracellular matrix, suggesting that neural crest defects...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (13): dev201527.
Published: 30 June 2023
... engineered hydrogels can advance our understanding of developmental biology. Hydrogels Extracellular matrix Mechanobiology In vitro culture National Institutes of Health http://dx.doi.org/10.13039/100000002 F30AG074508 National Science Foundation http://dx.doi.org/10.13039...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2023) 150 (6): dev201356.
Published: 24 March 2023
... proteins as well as aberrant adhesion between astrocytes and laminins in vascular basement membranes, resulting in pathological blood–brain barrier integrity. Angiogenesis Extracellular matrix Brain microenvironment Blood vessel Vascular smooth muscle cell Astrocyte Pericyte Megalencephalic...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2023) 150 (5): dev201047.
Published: 1 March 2023
... the developmental phagocytic removal of astrocyte bodies and resulted in increased astrocyte density. In addition, increased astrocyte density was associated with elevated proangiogenic extracellular matrix gene expression in C3- and C3aR-deficient retinas, resulting in increased vascular density. These data...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2022) 149 (19): dev201203.
Published: 17 October 2022
... of alveolar bone and cementum, respectively. However, the characteristics and lineage hierarchy of each cell type remain poorly defined. This study identified periodontal ligament associated protein-1 (Plap-1) as a PDL-specific extracellular matrix protein. We generated knock-in mice expressing CreER T2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev200140.
Published: 13 January 2022
... of how these cells recognise their ‘inside’ position to instruct their fate is unknown. Here, we show that provision of extracellular matrix (ECM) to isolated embryonic cells induces ICM specification and alters the subsequent spatial arrangement between epiblast (EPI) and primitive endoderm (PrE) cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199691.
Published: 22 October 2021
... simultaneously with growth of the heart. Cardiac growth during early heart morphogenesis is driven by deployment of cells from the second heart field (SHF) into both poles of the heart. Laminin is a core component of the extracellular matrix and, although mutations in laminin subunits are linked with cardiac...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (12): dev199281.
Published: 15 June 2021
... epithelial growth and differentiation. Laminin α5 loss compromises hormone receptor-positive luminal cell function and Wnt4-mediated crosstalk between epithelial cells. Laminin alpha 5 Extracellular matrix Basement membrane Mammary gland Luminal epithelial cell Wnt4 Postnatal development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev191320.
Published: 5 March 2021
...Christopher J. Derrick; Emily S. Noël ABSTRACT The developing heart is formed of two tissue layers separated by an extracellular matrix (ECM) that provides chemical and physical signals to cardiac cells. While deposition of specific ECM components creates matrix diversity, the cardiac ECM is also...
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193219.
Published: 18 January 2021
... and improves the resolution of transient collagen deposition. Through loss- and gain-of-function as well as pharmacological approaches, we provide evidence that Ccn2a is necessary for and promotes heart regeneration by enhancing the expression of pro-regenerative extracellular matrix genes, and by inhibiting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev193094.
Published: 23 September 2020
... protein family member doppel interacts with endothelial receptor tyrosine kinases to activate intracellular signaling pathways and promote blood vessel morphogenesis in the developing central nervous system. Vascular basement membrane Microenvironment Neurovascular unit Extracellular matrix...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev190983.
Published: 18 September 2020
...-licence-1-1/ Summary: This study reports a role for the COP-II secretory pathway and the cargo Col2a1 in controlling the migration of lymphatic endothelial cells in the developing embryo. Sec23a Mbtps1 Col2a1 Lymphangiogenesis Extracellular matrix Collagen Zebrafish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev175596.
Published: 28 May 2020
...David A. Cruz Walma; Kenneth M. Yamada ABSTRACT As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides both physical support and signaling regulation to cells. Some ECM molecules provide a fibrillar environment around cells, while others provide a sheet-like...
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (4): dev181420.
Published: 21 February 2020
...Chase D. Bryan; Macaulie A. Casey; Rebecca L. Pfeiffer; Bryan W. Jones; Kristen M. Kwan ABSTRACT Organogenesis requires precise interactions between a developing tissue and its environment. In vertebrates, the developing eye is surrounded by a complex extracellular matrix as well as multiple...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev185306.
Published: 2 December 2019
... induces fibroblast migration in 3D extracellular matrix (ECM) through regulation of actomyosin cytoskeleton and promotes force-mediated collagen remodeling by mammary fibroblasts. Moreover, FGF2 regulates production of ECM proteins by mammary fibroblasts, including collagens, fibronectin, osteopontin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev172668.
Published: 29 August 2019
...-2018). Deposited in PMC for release after 6 months. References Ahmed , M. and ffrench-Constant , C. ( 2016 ). Extracellular matrix regulation of stem cell behavior . Curr Stem Cell Rep.   2 , 197 - 206 . 10.1007/s40778-016-0056-2 Alexander , G. E. ( 2004 ). Biology...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev178400.
Published: 19 July 2019
... zebrafish as a model, we describe the in vivo dynamics and function of embryonic muscle progenitor cells (MPCs) in the dermomyotome. These cells are located in a superficial layer external to muscle fibers and express many extracellular matrix (ECM) genes, including collagen type 1 α2 ( col1a2 ). Utilizing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (11): dev172577.
Published: 3 June 2019
...Amsha Proag; Bruno Monier; Magali Suzanne ABSTRACT Tissue mechanics play a crucial role in organ development. They rely on the properties of cells and the extracellular matrix (ECM), but the relative physical contribution of cells and ECM to morphogenesis is poorly understood. Here, we have...
Includes: Supplementary data