..., but that neural crest migration is strikingly disrupted in double cdon ; boc mutant embryos. We further show that this migration phenotype is associated with defects in the differentiation of slow-twitch muscle cells, and the loss of a Col1a1a-containing extracellular matrix, suggesting that neural crest defects...

... Summary: This Primer introduces hydrogel technologies and discusses how engineered hydrogels can advance our understanding of developmental biology. Hydrogels Extracellular matrix Mechanobiology In vitro culture National Institutes of Health http://dx.doi.org/10.13039/100000002...

... defects in the expression of endothelial junctional proteins as well as aberrant adhesion between astrocytes and laminins in vascular basement membranes, resulting in pathological blood–brain barrier integrity. Angiogenesis Extracellular matrix Brain microenvironment Blood vessel Vascular smooth...

... the developmental phagocytic removal of astrocyte bodies and resulted in increased astrocyte density. In addition, increased astrocyte density was associated with elevated proangiogenic extracellular matrix gene expression in C3- and C3aR-deficient retinas, resulting in increased vascular density. These data...

... of alveolar bone and cementum, respectively. However, the characteristics and lineage hierarchy of each cell type remain poorly defined. This study identified periodontal ligament associated protein-1 (Plap-1) as a PDL-specific extracellular matrix protein. We generated knock-in mice expressing CreER T2...

... of how these cells recognise their ‘inside’ position to instruct their fate is unknown. Here, we show that provision of extracellular matrix (ECM) to isolated embryonic cells induces ICM specification and alters the subsequent spatial arrangement between epiblast (EPI) and primitive endoderm (PrE) cells...

... simultaneously with growth of the heart. Cardiac growth during early heart morphogenesis is driven by deployment of cells from the second heart field (SHF) into both poles of the heart. Laminin is a core component of the extracellular matrix and, although mutations in laminin subunits are linked with cardiac...

... epithelial growth and differentiation. Laminin α5 loss compromises hormone receptor-positive luminal cell function and Wnt4-mediated crosstalk between epithelial cells. Laminin alpha 5 Extracellular matrix Basement membrane Mammary gland Luminal epithelial cell Wnt4 Postnatal development...

...Christopher J. Derrick; Emily S. Noël ABSTRACT The developing heart is formed of two tissue layers separated by an extracellular matrix (ECM) that provides chemical and physical signals to cardiac cells. While deposition of specific ECM components creates matrix diversity, the cardiac ECM is also...

... and improves the resolution of transient collagen deposition. Through loss- and gain-of-function as well as pharmacological approaches, we provide evidence that Ccn2a is necessary for and promotes heart regeneration by enhancing the expression of pro-regenerative extracellular matrix genes, and by inhibiting...

... protein family member doppel interacts with endothelial receptor tyrosine kinases to activate intracellular signaling pathways and promote blood vessel morphogenesis in the developing central nervous system. Vascular basement membrane Microenvironment Neurovascular unit Extracellular matrix...

...-licence-1-1/ Summary: This study reports a role for the COP-II secretory pathway and the cargo Col2a1 in controlling the migration of lymphatic endothelial cells in the developing embryo. Sec23a Mbtps1 Col2a1 Lymphangiogenesis Extracellular matrix Collagen Zebrafish...

...David A. Cruz Walma; Kenneth M. Yamada ABSTRACT As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides both physical support and signaling regulation to cells. Some ECM molecules provide a fibrillar environment around cells, while others provide a sheet-like...

...Fabiana Cerqueira Campos; Cynthia Dennis; Hervé Alégot; Cornelia Fritsch; Adam Isabella; Pierre Pouchin; Olivier Bardot; Sally Horne-Badovinac; Vincent Mirouse ABSTRACT How extracellular matrix contributes to tissue morphogenesis is still an open question. In the Drosophila ovarian follicle, it has...

...Chase D. Bryan; Macaulie A. Casey; Rebecca L. Pfeiffer; Bryan W. Jones; Kristen M. Kwan ABSTRACT Organogenesis requires precise interactions between a developing tissue and its environment. In vertebrates, the developing eye is surrounded by a complex extracellular matrix as well as multiple...

... induces fibroblast migration in 3D extracellular matrix (ECM) through regulation of actomyosin cytoskeleton and promotes force-mediated collagen remodeling by mammary fibroblasts. Moreover, FGF2 regulates production of ECM proteins by mammary fibroblasts, including collagens, fibronectin, osteopontin...

...-2018). Deposited in PMC for release after 6 months. References Ahmed , M. and ffrench-Constant , C. ( 2016 ). Extracellular matrix regulation of stem cell behavior . Curr Stem Cell Rep.   2 , 197 - 206 . 10.1007/s40778-016-0056-2 Alexander , G. E. ( 2004 ). Biology...

... zebrafish as a model, we describe the in vivo dynamics and function of embryonic muscle progenitor cells (MPCs) in the dermomyotome. These cells are located in a superficial layer external to muscle fibers and express many extracellular matrix (ECM) genes, including collagen type 1 α2 ( col1a2 ). Utilizing...

...Amsha Proag; Bruno Monier; Magali Suzanne ABSTRACT Tissue mechanics play a crucial role in organ development. They rely on the properties of cells and the extracellular matrix (ECM), but the relative physical contribution of cells and ECM to morphogenesis is poorly understood. Here, we have...

... branching. Focal adhesions Cell polarity Tubulin acetylation Vesicle trafficking Cytoskeleton Extracellular matrix Mammary gland morphogenesis is a complex process involving basement membrane remodeling, polarized lumen formation, ductal elongation and branching that is essential...