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Keywords: Epithelial polarity
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Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199513.
Published: 5 October 2021
... stem cells modeling Huntington's Disease reveal that huntingtin CAG expansion perturbs the spatial restriction of the activin response in the context of the polarized epithelium. Huntington's disease Human embryonic stem cells 2D gastruloids TGFβ signaling Epithelial polarity CHDI...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev175497.
Published: 12 August 2019
... confers apical identity, Par-complex assembly and Crb accumulation to promote epithelial morphogenesis. Epithelial polarity Cdc42 Par6 Par3 Bazooka aPKC Crumbs Par complex Epithelial cell polarity and morphogenesis involve the specification and maturation of distinct plasma membrane...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev157909.
Published: 26 January 2018
... determinants by the basolateral PDZ protein Scribble . Nature   403 , 676 - 680 . 10.1038/35001108 Bilder , D. , Schober , M. and Perrimon , N. ( 2003 ). Integrated activity of PDZ protein complexes regulates epithelial polarity . Nat. Cell Biol.   5 , 53 - 58 . 10.1038/ncb897...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (7): 1305–1314.
Published: 1 April 2015
...Joaquim Grego-Bessa; Jeffrey Hildebrand; Kathryn V. Anderson The genetic control of mammalian epithelial polarity and dynamics can be studied in vivo at cellular resolution during morphogenesis of the mouse neural tube. The mouse neural plate is a simple epithelium that is transformed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2787–2797.
Published: 1 July 2013
... by The Company of Biologists Ltd 2013 ArhGEF18 Medaka Retina Rho signaling Teleost Epithelial polarity Epithelial sheets are essential for the development of many vertebrate organs, including the central nervous system and retina. Epithelial cells are highly polarized along...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (11): 2061–2070.
Published: 1 June 2012
... adaptor AP-1 in the C. elegans intestine, we found that AP-1 is required for epithelial polarity maintenance. Depletion of AP-1 subunits does not affect epithelial polarity establishment or the formation of the intestinal lumen. However, the loss of AP-1 affects the polarised distribution of both apical...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (11): 2050–2060.
Published: 1 June 2012
... polarize around a central lumen, provides a simple system with which to understand the coordination of epithelial polarity. We show that cell fate regulators cause pharyngeal precursor cells to group into a bilaterally symmetric, rectangular array of cells called the double plate. The double plate cells...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (5): 977–986.
Published: 1 March 2005
... Epithelial polarity Xenopus A conserved aspect of early vertebrate development is the polarisation of early blastomeres along an apicobasal axis and the generation of inner and outer cells by division of these polarised blastomeres. For example, in the mouse, Xenopus and zebrafish morula...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (9): 1939–1948.
Published: 1 May 2004
... pathway. Clones for null alleles of Pvr or expression of RNAi constructs showed no phenotypes in the wing disc or pupal wing, suggesting that Pvr plays a redundant role in this tissue. However, when uniform expression of a constitutively dimerizing receptor was induced, loss of epithelial polarity...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2657–2668.
Published: 15 June 2003
... Oriented cell division Neurogenesis Competence aPKC Par proteins Epithelial polarity Occludin The late blastula Xenopus embryo is shielded from the exterior by one layer of superficial cells that provide a tight-junction mediated epithelial seal. Underneath this superficial layer...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (1997) 124 (2): 353–362.
Published: 15 January 1997
...John K. Lee; Eric Brandin; Daniel Branton; Lawrence S. B. Goldstein ABSTRACT To understand the role of the spectrin-based membrane skeleton in generating epithelial polarity, we characterized the distribution of membrane skeletal components in Drosophila ovarian follicle cells and in somatic clones...