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Keywords: Epidermis
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Journal Articles
Journal: Development
Development (2022) 149 (6): dev199363.
Published: 17 March 2022
... have unraveled the importance of interactions of Myosin Vb with Rab11 and Rab10 and its cooperativity with mTOR signaling in regulation of cell size in the developing zebrafish epidermis under normal and perturbed homeostatic conditions. Our study shows that the interaction of Myosin Vb with Rab11...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199695.
Published: 23 September 2021
... and dynamics of transmembrane PCP proteins: Celsr1, Fz6 and Vangl2. Using the skin epidermis as a model, we characterize and verify the expression, localization and function of endogenously tagged Celsr1-3xGFP, Fz6-3xGFP and tdTomato-Vangl2 fusion proteins. Live imaging of Fz6-3xGFP in basal epidermal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199452.
Published: 3 September 2021
...Dimitris Katsanos; Mar Ferrando-Marco; Iqrah Razzaq; Gabriel Aughey; Tony D. Southall; Michalis Barkoulas ABSTRACT The epidermis of Caenorhabditis elegans is an essential tissue for survival because it contributes to the formation of the cuticle barrier as well as facilitating developmental...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (12): dev199542.
Published: 28 June 2021
... differentiation, induced extensive transcriptional reprogramming in the colonic epithelium and enhanced Apc -initiated adenoma development. The Ets DNA-binding domain of EHF is therefore essential for postnatal homeostasis of the epidermis and colonic epithelium, and its loss promotes colonic tumour development...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2021) 148 (4): dev198028.
Published: 26 February 2021
... stiffness decreased in det3 and clv3 det3 epidermises. Thus, we hypothesized that stem integrity depends on the epidermal resistance to mechanical stress. To formally test this hypothesis, we used the DET3 gene as part of a tissue-specific strategy to complement cell expansion defects. Epidermis-driven DET3...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2021) 148 (2): dev194969.
Published: 25 January 2021
...Kenji Nagata; Toshiki Ishikawa; Maki Kawai-Yamada; Taku Takahashi; Mitsutomo Abe ABSTRACT The differentiation of distinct cell types in appropriate patterns is a fundamental process in the development of multicellular organisms. In Arabidopsis thaliana , protoderm/epidermis differentiates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev193425.
Published: 11 December 2020
... required to establish PCP are poorly understood. Here, we identified a major role for the globular (G)-actin-binding protein thymosin-β4 (TMSB4X) in PCP establishment and cell adhesion in the developing epidermis. Depletion of Tmsb4x in mouse embryos hindered eyelid closure and hair-follicle angling owing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev194100.
Published: 15 November 2020
...Pooja Flora; Elena Ezhkova ABSTRACT Cell divisions and cell-fate decisions require stringent regulation for proper tissue development and homeostasis. The mammalian epidermis is a highly organized tissue structure that is sustained by epidermal stem cells (ESCs) that balance self-renewal and cell...
Journal Articles
Journal: Development
Development (2018) 145 (6): dev158543.
Published: 21 March 2018
... show that epidermis-specific ablation of Nir impairs epidermal stratification and barrier function, resulting in perinatal lethality. Nir-deficient epidermis lacks appendages and remains single layered during embryogenesis. Cell proliferation is inhibited, whereas apoptosis and p53 acetylation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4588–4603.
Published: 15 December 2017
... of the 141 genes that are differentially expressed in the epidermis of Arpc4 wt and Arpc4 eKO mice. Epidermises of Arpc4 wt and Arpc4 eKO littermates taken from three different nests (litter number indicated below each column) were isolated at P3-5 and processed for RNA sequencing. Genes showing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3066–3079.
Published: 1 September 2017
... by a novel cytoplasmic poly A-binding protein, SMED-PABPC2. Knockdown of smed-pabpc2 leads to defects in epidermal lineage specification, disorganization of epidermis and ECM, and deregulated wound healing, resulting in the selective failure of neoblast proliferation near the wound region. Polysome profiling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1498–1509.
Published: 15 April 2017
...Hsing-Jung Wu; Ji Won Oh; Dan F. Spandau; Sunil Tholpady; Jesus Diaz, III; Laura J. Schroeder; Carlos D. Offutt; Adam B. Glick; Maksim V. Plikus; Sachiko Koyama; John Foley Maintenance of specialized epidermis requires signals from the underlying mesenchyme; however, the specific pathways involved...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (1): 33–37.
Published: 1 January 2017
...Kaoru S. Imai; Hiroki Hikawa; Kenji Kobayashi; Yutaka Satou Epidermis and neural tissues differentiate from the ectoderm in animal embryos. Although epidermal fate is thought to be induced in vertebrate embryos, embryological evidence has indicated that no intercellular interactions during early...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (7): 1120–1125.
Published: 1 April 2016
..., strong correlation between ploidy and cell volume in pavement cells of the epidermis, this correlation was extremely weak in palisade mesophyll cells. Induction of epidermis cell identity based on the expression of the homeobox gene ATML1 in mesophyll cells enhanced the level of correlation between...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (6): 978–982.
Published: 15 March 2016
... of which remains unclear. We found that genotypes impaired in the TONNEAU1a ( TON1a ) gene display misoriented symmetric divisions in the epidermis and have no division defects in the underlying cortical tissue. The TON1a gene encodes a microtubule-associated protein. We show that in the ton1a mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (13): 2352–2363.
Published: 1 July 2015
... are poorly understood. Using the developing Xenopus epidermis and regenerating human upper airways, we reveal the importance of BMP signalling for the construction of vertebrate mucociliary epithelia. In Xenopus , attenuation of BMP activity is necessary for the specification of multiciliated cells (MCCs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (11): 1978–1983.
Published: 1 June 2015
..., endoreduplication and the acquisition of differentiated cellular morphologies. Here we show that the Arabidopsis phytocalpain DEFECTIVE KERNEL 1 (DEK1) promotes the differentiated epidermal state. Plants with reduced DEK1 activity produce cotyledon epidermis with protodermal characteristics, despite showing normal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (13): 2559–2567.
Published: 1 July 2014
...Troels Schepeler; Mahalia E. Page; Kim B. Jensen The epidermis is an integral part of our largest organ, the skin, and protects us against the hostile environment. It is a highly dynamic tissue that, during normal steady-state conditions, undergoes constant turnover. Multiple stem cell populations...
Journal Articles
Journal: Development
Development (2014) 141 (1): 101–111.
Published: 1 January 2014
.... , Rapisarda V. , Gordon K. B. , Smorodchenko A. D. , Poterlowicz K. , Ferone G. , et al . ( 2011 ). p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis . J. Cell Biol. 194 , 825 – 839 . Frye M. , Benitah S...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (22): 4533–4543.
Published: 15 November 2013
...Lingyu Li; Chang Liu; Steffen Biechele; Qingqing Zhu; Lu Song; Fredrik Lanner; Naihe Jing; Janet Rossant Ectoderm is one of the three classic germ layers in the early mouse embryo, with the capacity to develop into both the central nervous system and epidermis. Because it is a transient phase...
Includes: Supplementary data