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Keywords: Endothelial cell
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Journal Articles
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Neural development
Journal: Development
Development (2022) 149 (6): dev200472.
Published: 18 March 2022
... of adhesion, including activation of latent-TGFβs in the ECM. Quantitative sequencing of the brain endothelial cell transcriptome identifies TGFβ-regulated genes with putative links to blood vessel morphogenesis, including several genes linked to Wnt/β-catenin signaling. These results reveal that the β8...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199581.
Published: 26 October 2021
... are essential during embryonic development and disease pathogenesis. The diversity of endothelial cells (ECs) is transcriptionally evident and ECs undergo dynamic changes in gene expression during vessel growth and remodelling. Here, we investigated the role of the histone acetyltransferase HBO1 (KAT7), which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev146621.
Published: 12 August 2020
...Moritz Jakab; Hellmut G. Augustin ABSTRACT Blood vessels have long been considered as passive conduits for delivering blood. However, in recent years, cells of the vessel wall (endothelial cells, smooth muscle cells and pericytes) have emerged as active, highly dynamic components that orchestrate...
Journal Articles
Journal: Development
Development (2020) 147 (4): dev181560.
Published: 20 February 2020
... enriched in lung endothelial cells (ECs) throughout development. We find that loss of Cyp26b1 leads to reduction of alveolar type 1 cells, failure of alveolar inflation and early postnatal lethality in mouse. Furthermore, we observe expansion of distal epithelial progenitors, but no appreciable changes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (12): dev154898.
Published: 14 June 2018
... established regulators of cell cycle progression and cell death. Our analysis showed that the Wnt pathway co-receptors LRP5 and LRP6 have overlapping activities that mediate the Wnt/β-catenin signaling in hyaloid vascular endothelial cells (VECs). We also showed that both Myc and Cdkn1a are downstream...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (14): 2629–2639.
Published: 15 July 2017
... not been fully delineated. To elucidate the direct transcriptional regulators of Notch receptor expression in arterial endothelial cells, we used histone signatures, DNaseI hypersensitivity and ChIP-seq data to identify enhancers for the human NOTCH1 and zebrafish notch1b genes. These enhancers were able...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2428–2444.
Published: 1 July 2017
.... Wilson; Joshua D. Wythe The transcriptional pathways activated downstream of vascular endothelial growth factor (VEGF) signaling during angiogenesis remain incompletely characterized. By assessing the signals responsible for induction of the Notch ligand delta-like 4 (DLL4) in endothelial cells, we find...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1554–1565.
Published: 15 April 2017
..., while allowing cell motility. We have compared the contribution of two endothelial cell-specific adhesion proteins, VE-cadherin (VE-cad/Cdh5) and Esama (endothelial cell-selective adhesion molecule a), during angiogenic sprouting and blood vessel fusion (anastomosis) in the zebrafish embryo by genetic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (2): 211–220.
Published: 15 January 2017
... explants, we determined that VEGFR2-dependent signaling is required for salivary gland epithelial patterning. To test directly for a requirement for endothelial cells in instructive epithelial patterning, we developed a novel ex vivo cell fractionation/reconstitution assay. Immuno-depletion of CD31...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3933–3943.
Published: 1 November 2016
... by osteoblasts onto endothelial cells within bone and serves as a template for mineralisation, with ossification thus spatially and temporally following vascular patterning. Collagen type I Endothelial cell Vascular patterning Basement membrane Endochondral bone formation Morphogenesis Osteoid...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2973–2982.
Published: 15 August 2016
... vessel regression (‘pruning’) and a reduction in endothelial cell (EC) density in order to establish an efficient, hierarchical network. EC apoptosis has long been recognised for its association with angiogenesis, but its contribution to this process has remained unclear. We generated mice in which EC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (15): 2706–2715.
Published: 1 August 2016
... developmental and regenerative bone formation and providing niche microenvironments for various cell types. Bone Angiogenesis Blood vessels Endothelial cell Chondrocyte Osteoblast Osteoclast The skeletal system – a framework of bones and connective tissues – provides essential structural...
Journal Articles
Journal: Development
Development (2015) 142 (24): 4363–4373.
Published: 15 December 2015
... neuroepithelial cells and vascular endothelial cells. β8 integrin in the neuroepithelium promotes the activation of extracellular matrix (ECM)-bound latent transforming growth factor β (TGFβ) ligands and stimulates TGFβ receptor signaling in endothelial cells. Nrp1 in endothelial cells suppresses TGFβ activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3782–3792.
Published: 1 October 2014
... embryonic AV specification by promoting arterial, as opposed to venous, endothelial cell (EC) fate. To understand the essential role of endothelial Notch signaling in postnatal AV organization, we used inducible Cre-lox P recombination to delete Rbpj , a mediator of canonical Notch signaling, from postnatal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (7): 1480–1491.
Published: 1 April 2014
... vascularization is already complete. Using genetic mouse models, we demonstrate that VEGF regulates islet innervation indirectly through its effects on intra-islet endothelial cells. Our data indicate that formation of a VEGF-directed, intra-islet vascular plexus is required for development of islet innervation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (2): 448–459.
Published: 15 January 2014
... neuron 1 (Crim1), a type I transmembrane protein, is highly expressed in angiogenic endothelial cells. Conditional deletion of the Crim1 gene in vascular endothelial cells (VECs) causes delayed vessel expansion and reduced vessel density. Based on known Vegfa binding by Crim1 and Crim1 expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (19): 4031–4040.
Published: 1 October 2013
... functions by translating guidance cues into directional migration and mediating new contacts during anastomosis. To investigate the structural organisation, dynamics and functional importance of F-actin in endothelial cells (ECs) during angiogenesis in vivo , we generated a transgenic zebrafish line...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (19): 4041–4050.
Published: 1 October 2013
... the cellular changes necessary for remodeling, we performed live confocal imaging of cultured mouse embryos during vessel remodeling. Our data revealed that vessel diameter increase occurs via two distinct processes that are dependent on normal blood flow: vessel fusions and directed endothelial cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (20): 3859–3869.
Published: 15 October 2012
... ) has been shown to mediate interaction between endothelial and mural cells during vascular maturation. In vitro studies have identified S1P 1 as a pro-angiogenic factor. Here, we show that S1P 1 acts as an endothelial cell (EC)-autonomous negative regulator of sprouting angiogenesis during vascular...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (6): 1003–1013.
Published: 15 March 2010
... overlapping functions in particular cells remain unclear. Here, we show that the three Ras proteins dose-dependently regulate lymphatic vessel growth in mice. We find that lymphatic vessel hypoplasia is a common phenotype in Ras compound knockout mice and that overexpressed normal Ras in an endothelial cell...
Includes: Supplementary data