... eggs with clonally inherited genomes are formed from germ cells that had undergone premeiotic endoreplication, in which appropriate segregation is ensured by the formation of bivalents made from copies of identical chromosomes. We conclude that the induction of premeiotic endoreplication in reptiles...

...C. P. Unnikannan; Adriana Reuveny; Dvorah Grunberg; Talila Volk ABSTRACT DNA endoreplication has been implicated as a cell strategy for cell growth and in tissue injury. Here, we demonstrate that barrier-to-autointegration factor (BAF) represses endoreplication in Drosophila myofibers. We show...

... is not a viable option. DNA damage Endoreplication Myc Polyploidy Regeneration Yorkie Regeneration is limited for many organs due to the lack of a resident stem cell or progenitor cell population. As result, when injury or damage occur, organ failure may be delayed by the growth of cells...

... past the pairing stage of meiosis. Parthenogenesis Aspidoscelis Meiosis Endoreplication Synaptonemal complex Interspecific hybridization is a common phenomenon in plants and animals ( Mallet, 2007 ). If the parental species are closely related, first generation hybrids often retain...

... synchronously with their substrate, the body wall epithelium, providing a system to study how proportionality is maintained during animal growth. Here, we show that the microRNA bantam ( ban ) ensures coordinated growth of C4da dendrites and the epithelium through regulation of epithelial endoreplication...

..., endoreplication occurs frequently in many tissues. The resulting polyploid cells function in the larva but do not proliferate and contribute to the adult fly, with some recently studied exceptions. Fox et al., for example, discovered that intestinal papillar cells, which reclaim up to 90% of ingested water...

...Remmy Kasili; Cho-Chun Huang; Jason D. Walker; L. Alice Simmons; Jing Zhou; Chris Faulk; Martin Hülskamp; John C. Larkin Endoreplication, also called endoreduplication, is a modified cell cycle in which DNA is repeatedly replicated without subsequent cell division. Endoreplication is often...

... interacts with a novel BED (BEAF and Dref) finger protein that we have termed Sunspot (Ssp). Ssp transactivates Drosophila E2F-1 ( dE2F-1 ) and PCNA expression, and positively regulates the proliferation of imaginal disc cells and the endoreplication of salivary gland cells. Wg negatively regulates...

... the entire body, most likely by regulating feeding behavior. In muscles, InR/Tor signaling, Foxo and dMyc(Diminutive) are key regulators of endoreplication, which is necessary but not sufficient to induce growth. Mechanistically, InR/Foxo signaling controls cell cycle progression by modulating dmyc...

...′ ). Geminin remains low throughout the process of endoreplication, with low levels of the protein observed in the endocycling cells of the larval salivary glands( Fig. 1C,C′ ) and Malpighian tubules (see Fig. S1B,B′ in the supplementary material ). Thus, as is observed in mammalian trophoblasts...

... suggested a direct role for Myc in regulating growth. We have used dm 4 , a new null allele of the Drosophila diminutive ( dm ) gene, which encodes dMyc on the X chromosome, to investigate a role for dMyc in larval endoreplicating tissues,where cellular growth and DNA replication occur in the absence...

...Jeffrey J. Esch; Margaret Chen; Mark Sanders; Matthew Hillestad; Sampson Ndkium; Brian Idelkope; James Neizer; M. David Marks Previously characterized Arabidopsis gl3 mutants have trichomes that are smaller, less branched and undergo fewer rounds of endoreplication than wild-type trichomes. A new...

... by suppressing endoreduplication. © 2002. 2002 Drosophila Myb Transcription factor Replication Mitosis Endoreplication Endocycle Endoreduplication Genomic stability The proto-oncogene c- myb ( MYB – Human Gene Nomenclature Database) is the cellular homolog of the transduced retroviral...

... and imaginal disc cells, as well as the endoreplicating cells in other larval tissues. After cell cycle activation, mitotic and endoreplicating cells respond differently to the withdrawal of nutrition: mitotic cells continue to proliferate in a nutrition-independent manner, while most endoreplicating cells...

.... In this example, pairs of cells that have lost Cyclin A are seen (arrowhead). (D′) Enlarged view of DAPI staining of D. Bar: 50 μm (A-D). The function of Cdc2 in inhibiting endoreplication and its relationship to esg has been investigated and it has been found that many diploid cells lacking Dmcdc2...