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Development (2007) 134 (16): 3041–3048.
Published: 15 August 2007
...Rita C. R. Perlingeiro Endoglin (ENG), an ancillary receptor for several members of the transforming growth factor (TGF)-beta superfamily, has a well-studied role in endothelial function. Here, we report that endoglin also plays an important role early in development at the level...
Rita L. C. Carvalho, Leon Jonker, Marie-José Goumans, Jonas Larsson, Peter Bouwman, Stefan Karlsson, Peter ten Dijke, Helen M. Arthur, Christine L. Mummery
Development (2004) 131 (24): 6237–6247.
Published: 15 December 2004
... dyplasia and recurrent haemorrhage. Germline mutations in one of two different genes,endoglin or ALK1 can cause HHT. Both are members of the transforming growth factor (TGF) β receptor family of proteins, and are expressed primarily on the surface of endothelial cells (ECs). Mice that lack endoglin...