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Keywords: Endocardium
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Journal Articles
Journal: Development
Development (2022) 149 (9): dev190421.
Published: 9 May 2022
...Samuel J. Capon; Veronica Uribe; Nicole Dominado; Ophelia Ehrlich; Kelly A. Smith ABSTRACT The endocardium plays important roles in the development and function of the vertebrate heart; however, few molecular markers of this tissue have been identified and little is known about what regulates its...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev185900.
Published: 17 June 2020
... of intercellular junctions and the maintenance of identity in the endocardium . Dev. Biol.   383 , 214 - 226 . 10.1016/j.ydbio.2013.09.019 Sehnert , A. J. , Huq , A. , Weinstein , B. M. , Walker , C. , Fishman , M. and Stainier , D. Y. R. ( 2002 ). Cardiac troponin T...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev172619.
Published: 8 May 2019
...Leshana Saint-Jean; Nikolaos Barkas; Cristina Harmelink; Kevin L. Tompkins; Rebecca J. Oakey; H. Scott Baldwin ABSTRACT The endocardium interacts with the myocardium to promote proliferation and morphogenesis during the later stages of heart development. However, the role of the endocardium...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev163378.
Published: 2 July 2018
...Tania Papoutsi; Luis Luna-Zurita; Belén Prados; Stéphane Zaffran; José Luis de la Pompa ABSTRACT Signaling interactions between the myocardium and endocardium pattern embryonic cardiac regions, instructing their development to fulfill specific functions in the mature heart. We show that ectopic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1425–1440.
Published: 15 April 2017
..., we reveal a highly dynamic endocardium during cardiac regeneration, including changes in cell morphology, behaviour and gene expression. These events lay the foundation for an initial expansion of the endocardium that matures to form a coherent endocardial structure within the injury site. We studied...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (14): 2593–2602.
Published: 15 July 2016
... incorporating into endocardium. In alk1 -deficient embryos, migration against flow is dampened and migration in the direction of flow is enhanced. Altered migration results in decreased endothelial cell number in arterial segments proximal to the heart and increased endothelial cell number in arterial segments...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2217–2227.
Published: 15 June 2016
... © 2016. Published by The Company of Biologists Ltd 2016 Summary: 3D analyses of cardiac valve formation in zebrafish illustrate the complex cellular rearrangements that occur during this process in vivo . Cardiac valves Endocardium Live imaging Notch Wnt Zebrafish Apc...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (3): 373–386.
Published: 1 February 2016
... instructive roles of the endocardium, as a sensor and signal transducer of biophysical forces induced by blood flow, and as an angiocrine signalling centre that is involved in myocardial cellular morphogenesis, regeneration and reprogramming. In this Review, we discuss how the endocardium develops, how...
Journal Articles
Journal: Development
Development (2015) 142 (13): 2304–2315.
Published: 1 July 2015
... interactions involved in establishing endocardial identity are poorly understood. The endocardium develops in tight association with cardiomyocytes. To test for a potential role of the myocardium in endocardial morphogenesis, we used two different zebrafish models deficient in cardiomyocytes: the hand2 mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (3): 660–666.
Published: 1 February 2013
... contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes . Nature 464 , 601 - 605 . Kikuchi K. , Holdway J. E. , Major R. J. , Blum N. , Dahn R. D. , Begemann G. , Poss K. D. ( 2011 ). Retinoic acid production by endocardium and epicardium...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (21): 4777–4787.
Published: 1 November 2011
...Michal Milgrom-Hoffman; Zachary Harrelson; Napoleone Ferrara; Elazar Zelzer; Sylvia M. Evans; Eldad Tzahor The embryonic heart is composed of two cell layers: the myocardium, which contributes to cardiac muscle tissue, and the endocardium, which covers the inner lumen of the heart. Whereas...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (16): 3421–3430.
Published: 15 August 2011
... interests statement The authors declare no competing financial interests. 9 6 2011 © 2011. Cardiomyocyte Genetic ablation Heart regeneration Zebrafish Epicardium Endocardium Heart failure Heart failure is a disabling, costly human condition of insufficient...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (22): 3867–3875.
Published: 15 November 2010
... migration rather than oriented cell division, and that ErbB2 cell-autonomously regulates this process. * Author for correspondence ( didier.stainier@ucsf.edu ) Competing interests statement 20 9 2010 © 2010. Cardiac trabeculation Endocardium SPIM ErbB2 Zebrafish...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (12): 2379–2386.
Published: 15 June 2007
..., we find that myocardial-endocardial interactions influence the second phase by regulating the induction, direction and duration of cardiomyocyte movement. Thus, the endocardium plays a crucial early role in cardiac morphogenesis,organizing cardiomyocytes into a configuration appropriate for heart...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (18): 4193–4204.
Published: 15 September 2005
... Hospital Medical Center, OH 45229,USA ‡ Present address: National Institute for Medical Research, Division of Developmental Biology, Mill Hill, London NW7 1AA, UK 7 7 2005 ©2005. 2005 Heart AV canal Endocardium Notch Calcineurin Zebrafish Understanding how cardiac...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (5): 1137–1146.
Published: 1 March 2005
... canal,intensifies and extends from E9.5 to E11.5 in endocardium along the atrioventricular canal and outflow tract. By E12.5, the enhancer activity is accentuated in endocardial cells of forming valves. Sequential deletion analysis identified that a 250 bp DNA fragment at the 3′ end of the intron 1...
Journal Articles
Journal: Development
Development (2004) 131 (13): 3081–3091.
Published: 1 July 2004
... consisting of two tissue layers, the myocardium and endocardium. The cellular and molecular mechanisms responsible for the separation of ventricular and atrial lineages are not well understood. To test models of cardiac chamber specification, we generated a high-resolution fate map of cardiac chamber...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (17): 4045–4055.
Published: 1 September 2002
... 1 ). *Author for correspondence (e-mail: nemerm@ircm.qc.ca ) 4 6 2002 © 2002. 2002 Endocardium GATA5 Heart Development Transcription Factors NF-AT In human, cardiac septal and valvular abnormalities are the most frequent birth defects, yet few regulators...