... further reveals clusters of co-regulated genes, with in situ hybridization confirming the domain-specific expression of novel genes. We then created loss-of-function alleles for 12 genes and uncovered antagonistic functions of two new Edn1 targets, follistatin a ( fsta ) and emx2 , in regulating...

...Yoko Suda; Kenji Kokura; Jun Kimura; Eriko Kajikawa; Fumitaka Inoue; Shinichi Aizawa We have analyzed Emx2 enhancers to determine how Emx2 functions during forebrain development are regulated. The FB (forebrain) enhancer we identified immediately 3′ downstream of the last coding exon is well...

... controlling limb morphogenesis have limited influence on scapula formation. Analysis of mouse mutants for Pbx and Emx2 genes has suggested their potential roles in girdle development. In this study, by generating compound mutant mice, we examined the genetic control of scapula development by Pbx genes...

..., cyclin D1 (Ccnd1) and Emx2. This is associated with anti-apoptotic and proliferative effects in epithelial progenitors, whereas cells with impaired TCF/Lef-dependent transcription are progressively depleted from the epithelial lineage. In vivo,TCF/Lef-responsive genes comprise a conserved transcriptional...

... pathway. In addition,loss of β-catenin results in a severe agenesis of the scapula. Concurrently, the expression of two genes, Pax1 and Emx2 ,which have been implicated in scapula development, is lost in β-catenin loss-of-function limbs; however, only Emx2 is upregulated in gain-of-function limbs...

..., neurons located at the ventral midbrain-forebrain border (MFB) give rise to the medial longitudinal fascicle(mlf) and the posterior commissure (pc). We demonstrate that the homeobox genes Sax1, Six3, Emx2 and Pax6 are expressed in distinct domains in this area, suggesting that the specification of mlf...

... to maintain anterior neuroectoderm once induced. Furthermore, Otx2 under the AN enhancer cooperates with Emx2 in diencephalon development. The AN enhancer region is conserved among mouse, human and Xenopus ; moreover, the counterpart region in Xenopus exhibited an enhancer activity in mouse anterior...

.... During neurulation, loss of GPC4 disrupts expression of dorsal forebrain genes, such as Emx2 , whereas genes marking the ventral forebrain and posterior central nervous system continue to be expressed. This loss of GPC4 activity also causes apoptosis of forebrain progenitors during neural tube closure...

... of the cerebral cortex and meninges. These heterotopias are frequently observed as microscopic abnormalities in the brains of individuals with central nervous system (CNS) malformations and epilepsy. Previous work has demonstrated that the function of Emx2 , which encodes a homeodomain transcription factor...

... fates. * Author for correspondence (e-mail: cliff@drugs.bsd.uchicago.edu ) 12 9 2002 ©2002. 2002 Bain nuclei Oculomotor neurons Red nucleus Homeobox genes Emx2 Sonic hedgehog FGF8 Isthmus Chick Mouse In the adult brain, many neurons are organized into well...

...Koji Shinozaki; Toshihiko Miyagi; Michio Yoshida; Takaki Miyata; Masaharu Ogawa; Shinichi Aizawa; Yoko Suda Emx1 and Emx2 , mouse orthologs of the Drosophila head gap gene, ems , are expressed during corticogenesis. Emx2 null mutants exhibit mild defects in cortical lamination. Segregation...

... nervous system and for cell homeostasis/replacement within specific brain regions throughout adulthood. The role of genetic determinants in this process is largely unknown. We report the expression of the homeobox transcription factor Emx2 within the periventricular region of the adult telencephalon...

...Norimasa Miyamoto; Michio Yoshida; Shigeru Kuratani; Isao Matsuo; Shinichi Aizawa ABSTRACT The homeobox gene Emx2 is a mouse homologue of a Drosophila head gap gene empty spiracles ( ems ) and is essential for the development of dorsal telencephalon ( Yoshida, M., Suda, Y., Matsuo, I., Miyamoto, N...

...Michio Yoshida; Yoko Suda; Isao Matsuo; Norimasa Miyamoto; Naoki Takeda; Shigeru Kuratani; Shinichi Aizawa ABSTRACT The genes Emx1 and Emx2 are mouse cognates of a Drosophila head gap gene, empty spiracles , and their expression patterns have suggested their involvement in regional patterning...

...M. Pellegrini; A. Mansouri; A. Simeone; E. Boncinelli; P. Gruss ABSTRACT Emx 1 and 2 are the murine homologues of the Drosophila empty spiracles gene and based on their expression pattern may be involved in the regional specification of the mammalian forebrain. During early embryogenesis, Emx2...