... that is dictated by their tightly linked genomic organization. Although their genetic function during embryonic development has been interrogated, less is known about how these transcription factors regulate downstream genes to direct morphogenetic events. Moreover, the continued expression and function of Hox...

... induces ER stress and UPR, thus leading to defects of oogenesis. Given that depletion of eef1a1l2 rescues the oogenesis defect and alleviates ER stress and UPR in the nanog mutant, we wondered whether depletion of eef1a1l2 would have a rescue effect on the early embryonic development defects...

...Yinan Zhao; Dandan Bai; You Wu; Dan Zhang; Mengying Liu; Yingpu Tian; Jinhua Lu; Haibin Wang; Shaorong Gao; Zhongxian Lu ABSTRACT How maternal Ezh1 and Ezh2 function in H3K27 methylation in vivo in pre-implantation embryos and during embryonic development is not clear. Here, we have deleted Ezh1...

... induce a graded response within such domains. Drosophila Embryonic Development Gastrulation Morphogen Transcription Weizmann Institute of Science http://dx.doi.org/10.13039/501100001735 United States-Israel Binational Science Foundation 2015063 Weizmann...

... at the single-cell level and establishment of patterns at the tissue-wide level. Here, we emphasize that the general principles of embryonic development and tissue homeostasis are similar, and argue that interactions between these disciplines will be beneficial for both research fields. * These authors...

...Ashley V. Schwartz; Karilyn E. Sant; Julian Navarrete; Uduak Z. George ABSTRACT Optimal embryonic development plays a major role in the health of an individual beyond the developmental stage. Nutritional perturbation during development is associated with cardiovascular and metabolic disease later...

... thickening of the epithelium in the diastema anterior to the first developing molar is an early signaling center, the molar initiation knot (IK), which is required for the progression of mammalian molar tooth development. Cell division Migration Embryonic development Tooth Signaling center Wnt...

... repeat ( Fig. 1 A) were cloned into px330 using a standard protocol. The primers used to clone the sgRNAs have been previously described ( De Iaco et al., 2017 ). In summary, the present work confirms that DUX promotes murine embryonic development. In spite of also surprisingly demonstrating...

... are the two key regulators for the establishment of amphioxus left-right asymmetry, likely representing an evolutionarily conserved mechanism in deuterostomes. Amphioxus Left-right asymmetry Embryonic development Hh signalling Cilium Bilateral symmetry is a fundamental feature of many animal...

... of protein function with the precision of a pulse of laser light. This Primer gives an overview of the most commonly used optogenetic tools and their application in developmental biology. Embryonic development Optogenetics Signaling Synthetic biology Tissue morphogenesis Optogenetics...

... to active H3K9me3/2 demethylation in in vitro fertilized (IVF) embryos and are deficiently expressed in cloned embryos at the time of EGA. Moreover, KDM4E plays a more crucial role in IVF and SCNT embryonic development, and overexpression of KDM4E can restore the global transcriptome, improve blastocyst...

...Guangwei Hu; Guang Li; Hui Wang; Yiquan Wang Correct patterning of left-right (LR) asymmetry is essential during the embryonic development of bilaterians. Hedgehog (Hh) signaling is known to play a role in LR asymmetry development of mouse, chicken and sea urchin embryos by regulating Nodal...

... in the field of craniofacial biology. Xenopus laevis Embryonic development Stage series Craniofacial patterning Eunice Kennedy Shriver National Institute of Child Health and Human Development 10.13039/100009633 R01HDO81326 In 1956, the editors Peter Nieuwkoop and Job Faber...

... in mouse embryos reveals a new mechanism of fluid shear stress-mediated signaling involving syndecan 4-dependent upregulation of the PCP protein Vangl2. Syndecan 4 Lymphatic remodeling Embryonic development Tissue remodeling is an important process during organogenesis. In the vascular...

... during fertilization and preimplantation embryonic development. Germline-specific Dicer and Drosha conditional knockout (cKO) mice produce gametes (i.e. sperm and oocytes) partially deficient in miRNAs and/or endo-siRNAs, thus providing a unique opportunity for testing whether normal sperm (paternal...

...Alexander R. Langley; James C. Smith; Derek L. Stemple; Steven A. Harvey The initial phases of embryonic development occur in the absence of de novo transcription and are instead controlled by maternally inherited mRNAs and proteins. During this initial period, cell cycles are synchronous and lack...

..., expression of the reporter gene provided a defined marker for macrophage-lineage cells, identifying the earliest stages in the yolk sac, throughout embryonic development and in all adult tissues. The reporter genes permit detailed and dynamic visualisation of embryonic chicken macrophages. Chicken embryonic...

... during pre-implantation embryonic development and their function is suppressed during oocyte meiosis. Here, we review the roles of small non-coding RNAs during the early stages of mammalian development, from gamete maturation through to gastrulation. * Author for correspondence ( Blellochr...

... Embryonic development Fibroblast growth factors (FGFs) and their receptor tyrosine kinases control a multitude of developmental processes, including proliferation, survival, migration and differentiation. In this review, we discuss recently emerging evidence that FGF signaling plays an important...

...Thimios A. Mitsiadis; Daniel Graf; Hansueli Luder; Thomas Gridley; Gilles Bluteau The Notch signalling pathway is an evolutionarily conserved intercellular signalling mechanism that is essential for cell fate specification and proper embryonic development. We have analysed the expression...