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Keywords: Ecdysone
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Journal Articles
Journal: Development
Development (2021) 148 (6): dev195057.
Published: 19 March 2021
... of the third instar. This change in barrier permeability is driven by the steroid hormone ecdysone and correlates with changes in localization of Coracle, a component of the septate junctions that is required for the late-larval impermeable epithelial barrier. Based on these observations, we propose...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev190066.
Published: 27 November 2020
... metamorphosis, after adulthood is reached. Prothoracic gland E93 FTZ-F1 Ecdysone Insect metamorphosis MEKRE93 pathway One of the most successful innovations in insect evolution is metamorphosis, as shown by the fact that more than 95% of extant insects develop through this type...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev188110.
Published: 24 July 2020
... identify the Ecdysone Receptor (EcR) in the PTTH-expressing neurons (PTTHn) as a regulator of developmental maturation onset. Loss of EcR in these PTTHn impairs PTTH signaling, which delays maturation. We find that the steroid ecdysone dose-dependently affects Ptth transcription, promoting its expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (6): dev181909.
Published: 16 March 2020
... in the same cells to respond to spatial cues through regulation of chromatin accessibility. Temporal transcription factor Chromatin accessibility Enhancer Gene regulation Ecdysone Drosophila Cis -regulatory regions such as enhancers and promoters interpret multiple types of inputs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev182568.
Published: 20 December 2019
...Coralie Drelon; Michael F. Rogers; Helen M. Belalcazar; Julie Secombe ABSTRACT In Drosophila , the larval prothoracic gland integrates nutritional status with developmental signals to regulate growth and maturation through the secretion of the steroid hormone ecdysone. While the nutritional signals...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (8): dev163592.
Published: 17 April 2019
... to pupal stages but the expression of Fos is specifically activated by ecdysone receptor B1 (EcRB1) at early pupal stages, suggesting that ecdysone signaling provides temporal control of the regulation of dendrite pruning by JNK signaling. Thus, our work not only identifies a novel pathway involved...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev165654.
Published: 2 November 2018
...., 2002 ; Rulifson et al., 2002 ; Zhang et al., 2009 ). To further define the role of ecdysone signalling in IPCs, we first characterized in detail the spatiotemporal expression pattern of the Dilp2-GAL4 R - driver. Starting from late embryonic stages and throughout larval development, the Dilp2-GAL4...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (6): dev160101.
Published: 19 March 2018
...H. Frederik Nijhout; Emily Laub; Laura W. Grunert ABSTRACT The wing imaginal disks of Lepidoptera can be grown in tissue culture, but require both insulin and ecdysone to grow normally. Here, we investigate the contributions the two hormones make to growth. Ecdysone is required to maintain mitoses...
Journal Articles
Journal: Development
Development (2018) 145 (6): dev159699.
Published: 14 March 2018
... by the duration of this phase, which is under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev154534.
Published: 25 January 2018
... in the optic lobe during early larval stages by boosting symmetric self-renewing divisions while preventing differentiation. Neuroepithelium differentiation in late larvae requires the transcriptional silencing of chinmo by ecdysone, the main steroid hormone, therefore allowing coordination of neural stem cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4406–4421.
Published: 1 December 2017
.../ Summary: Identification of a requirement for 20-hydroxyecdysone in tissue patterning leads to the discovery that dynamic cell rearrangements and shape changes contribute to oriented tissue growth in the Drosophila wing disc. Ecdysone Insulin Culture Imaginal disc Proliferation We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3591–3603.
Published: 1 October 2016
... from environmental and genetic noise. Fig. 6. Transcriptional circuitry indicates complex controls of the InR gene for temporal or spatial regulation. (A) Transcriptional circuitry of the InR gene. Regulatory inputs relating to FOXO, ecdysone, E2F1, Rbf1 and additional activators...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2410–2416.
Published: 1 July 2016
... timing is believed to be determined by the release of a steroid hormone, ecdysone (E), from the prothoracic gland. Here, we demonstrate that the ecdysone-20-monooxygenase Shade determines pupation timing by converting E to 20-hydroxyecdysone (20E) in the fat body, which is the organ that senses...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (21): 3758–3768.
Published: 1 November 2015
... with water and frozen in liquid nitrogen and stored at −80°C. 20-Hydroxyecdysone, 2-deoxy-20-hydroxyecdysone, polypodine B and Girard T reagent [1 - (carboxymethyl)trimethylammonium chloride hydrazide] were purchased from Sigma-Aldrich Chemie (Munich, Germany); ecdysone from A. G. Scientific...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 883–892.
Published: 1 March 2015
... and germ cell differentiation, and promotes the accumulation of Broad-Z1, which is also a target of the steroid hormone ecdysone. Epistasis analysis shows that Activin controls cell proliferation in an ecdysone-independent manner and TF differentiation by affecting ecdysone targets. We propose...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (20): 3955–3965.
Published: 15 October 2014
... to fine-tune the dynamics of hormone production. In Drosophila , transient increases of the steroid prohormone ecdysone, produced at each larval stage, are necessary to trigger moulting and metamorphosis. Binding of the active ecdysone (20-hydroxyecdysone) to its receptor (EcR) is followed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (23): 4730–4739.
Published: 1 December 2013
... coordinate growth and timing of maturation during development, the mechanisms generating these pulses are not known. Here we show that the ecdysone steroid pulse that drives the juvenile-adult transition in Drosophila is determined by feedback circuits in the prothoracic gland (PG), the major steroid...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (13): 2693–2703.
Published: 1 July 2011
... that activin signaling regulates competence of the prothoracic gland to receive PTTH and insulin signals, and that these two pathways act at the mRNA and post-transcriptional levels, respectively, to control ecdysone biosynthetic enzyme expression. This dual regulatory circuitry may provide a cross-check...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (21): 3675–3685.
Published: 1 November 2010
... could be an ancient and conserved principle of membrane homeostasis. * Author for correspondence ( kurzchalia@mpi-cbg.de ; eaton@mpi-cbg.de ) Competing interests statement 24 8 2010 © 2010. Drosophila Ecdysone Growth Membranes Sphingolipids Sterols...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (12): 1991–1999.
Published: 15 June 2010
... guided by a principal steroid hormone, ecdysone. Among the multiple conversion steps for synthesizing ecdysone from dietary cholesterol, the conversion of 7-dehydrocholesterol to 5β-ketodiol, the so-called ‘Black Box’, is thought to be the important rate-limiting step. Although a number of genes...
Includes: Supplementary data